Analysis of Adverse Drug Reactions Spontaneously Reported to Adverse Drug Monitoring Centre of a Tertiary Care Hospital–prospective Study

Kulkarni, Gajanan P.; Patil, Lokesh V.

doi:10.22159/ijcpr.2018v10i1.24403

Cited by 4 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are in accordance with Vijayakumar and Dhanaraju where 77% recovered from reactions [6]. The early detection and management of adverse reactions can reduce health and economic burden on patients, and it also improves patients adherence and enhances health surveillance [17][18][19].…”

Section: Discussionsupporting

confidence: 84%

Assessment of Adverse Drug Reactions Occurring at Department of Neurology of a Tertiary Care Hospital in India

Grace

Saina

Maheswari

et al. 2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The purpose of this study was to assess the incidence and pattern of adverse drug reactions (ADRs) reported from the department of neurology of a tertiary care hospital in Karnataka, India.Methods: It is a hospital-based prospective, observational study, conducted among the inpatients of all age groups of either sex for a period of 6 months. ADRs were reported by the clinical pharmacists and physicians of this hospital. ADRs obtained were categorized based on its causality, severity, preventability, predictability, and outcomes. Binary logistic regression was carried out to identify the predictors of ADR and Kaplan–Meier analysis was performed for survival analysis.Results: A total of 250 patients were enrolled for the study in which 108 (43%) patients were presented with at least one ADR and a total of 212 ADRs were observed. The highest rate of ADRs was observed with antiepileptics 61 (29.5%). The most commonly reported that ADRs were skin reactions 23 (10.8%). Causality was assessed using three different scales which showed that most of the ADRs were probable. Severity, preventability, and predictability were assessed, of which 125 (59%) ADRs were moderate, 192 (90.6%) ADRs were probably preventable, and 156 (73.6%) ADRs were predictable, respectively. The outcomes showed that 150 (70.1%) patients recovered from the reactions. Predictors such as polypharmacy and duration of stay were found to be significant.Conclusion: The study concluded that the prevalence of ADRs in the department of neurology is high. Thus, early detection and management of ADRs are essential to avoid further complications of the reaction.

show abstract

Section: Discussionsupporting

confidence: 84%

Assessment of Adverse Drug Reactions Occurring at Department of Neurology of a Tertiary Care Hospital in India

Grace

Saina

Maheswari

et al. 2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…This suggests that pharmacovigilance authorities should take necessary steps to urgently design interventional programs in order to increase the knowledge and awareness of pharmacists regarding the ADR reporting process. An effective implementation of ADR monitoring would result in better and safe use of these drugs which would ultimately result in better patient care [30].…”

Section: Discussionmentioning

confidence: 99%

Pharmacists Compliance to Practice Regulations and Good Professional Practice: A Case Study of Nigerian Community Pharmacists

Anyachebelu

Aluh

2018

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: This study was designed to assess community pharmacists’ compliance to rules and regulations guiding the practice of pharmacy in Anambra state, Nigeria.Methods: The study was carried out using a mixed method. In the first phase, adapted and validated questionnaire was used to obtain demographic data and information on some practice standards. While in the second phase, the researcher interviewed the practicing pharmacists on some of the key practice standards followed by observation of the items included in the interview. Statistical analysis was computed using SPSS and minitab versions 23.0 and 14.0 respectively. Descriptive analysis was carried out on the demographic items and other sections of the questionnaire. Quantitative data were analysed by computing frequency tables. Average percentage score for each section of the questionnaire was calculated. One-way ANOVA [with post hoc test—LSD] and Independent-Samples T Test were used to examine significance relationship between demographic variables and the different dimensions of the questionnaire.Results: The response rate to the study questionnaire was 82%. While the questionnaire study had a mean good compliance level to environmental and dispensing practice standards, the interview and observation phase observed poor compliance to some items in this section. The study further observed good implementation level for pharmaceutical care, except for proper documentation. Although the pharmacists’ knowledge of pharmacovigilance activities was observed to be fair, their involvement in the activity was poor.Conclusion: The Overall findings of the study did not record an excellent compliance level to good professional practice by community pharmacists in Anambra state, Nigeria.

show abstract

“…Hypoglycaemia was the most common individual ADR which was encountered in 41.89% of the patients which was similar to the study done by Kulkarni diseases is the main leading cause of morbidity and mortality among diabetic patients, but such ADR is not reported in my study. 14 Among the various classes of anti-diabetic drugs used sulfonylureas is the commonest drug developed ADRs (51.35%), followed by biguanides (29.73%). This trend goes in parallel to studies done by Nirojini PS et al 15 In this study DPP4 inhibitors showed least (1.35%) ADRs may be due to the fact that these group of drugs prescribed much less in numbers to patients or due to high efficacy and lesser side effects.…”

Section: Discussionmentioning

confidence: 99%

A study on adverse drug reactions of oral anti-diabetic agents in patients with type II diabetes mellitus in Hi-Tech Medical College and Hospital, Bhubneswar, Odisha, India

Dey

Mohanty

Prasad

et al. 2019

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Background: Diabetes mellitus is an emerging non communicable, life style disease & the use of anti-diabetics has been increasing. Adverse drug reactions (ADRs) are well known to occur with any class of drugs when used in normal doses for the management of diseases. Anti-diabetic agents are no exception to this. The study of ADRs is the concern of the field known as pharmacovigilance. The objective of the present study was to analyze and describe the patterns of adverse events associated with the use of oral Anti-diabetic agentsMethods: A hospital based prospective observational study at Hi-Tech Medical College and Hospital, Bhubaneswar, Orissa. Convenience samples of 266 adult patients, prescribed with oral anti-diabetic agents from October 2016 to November 2018 were selected, out of which 74 patients developed ADRs. Data collected from available prescriptions. The severity assessment is done using the Hartwig and Siegal scale and preventability assessment using modified Schumock and Thornton is done.Results: Study suggests that female predominance in 41 (55.40%) patients with maximum cases of 43.24% in age group of 61-70 years age group. Maximum ADRs reported related to endocrine system seen in 36 (48.67%) patient population. Sulfonylureas 38 (51.35%) shows the largest numbers of ADR. The maximum ADRs reported were probable (56.73%). The severity assessment using the Hartwig and Siegal scale indicated that the majority of the ADRs were 63 (81.63%) as mild cases respectively.Conclusions: This study has provided evidence of monitoring and detecting ADRs and their management through therapeutic interventions which is beneficial in the better patient outcome.

show abstract

Analysis of Adverse Drug Reactions Spontaneously Reported to Adverse Drug Monitoring Centre of a Tertiary Care Hospital–prospective Study

Cited by 4 publications

References 8 publications

Assessment of Adverse Drug Reactions Occurring at Department of Neurology of a Tertiary Care Hospital in India

Assessment of Adverse Drug Reactions Occurring at Department of Neurology of a Tertiary Care Hospital in India

Pharmacists Compliance to Practice Regulations and Good Professional Practice: A Case Study of Nigerian Community Pharmacists

A study on adverse drug reactions of oral anti-diabetic agents in patients with type II diabetes mellitus in Hi-Tech Medical College and Hospital, Bhubneswar, Odisha, India

Contact Info

Product

Resources

About