Analysis of adenoid cystic carcinoma treated by radiotherapy

Hosokawa, Yoichiro; Ohmori, Keiichi; Kaneko, Masanori; Yamasaki, Michimasa; Ahmed, Mohiuddin; Arimoto, Takuro; Irie, G

doi:10.1016/0030-4220(92)90391-3

Cited by 26 publications

(13 citation statements)

References 14 publications

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“…Some authors suggest exclusive radiation therapy of adenoid cystic carcinomas, which should be considered in particular for elderly or multimorbid patients. [24][25][26][27] Chemotherapy, on the other hand, is only administered for palliation. 1,13,17,28,29 The survival rates in the literature correspond to our data.…”

Section: Discussionmentioning

confidence: 99%

Adenoid Cystic Carcinoma of the Skull Base

Issing¹,

Hemmanouil²,

Stöver³

et al. 1999

Skull Base

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Section: Discussionmentioning

confidence: 99%

Adenoid Cystic Carcinoma of the Skull Base

Issing¹,

Hemmanouil²,

Stöver³

et al. 1999

Skull Base

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“…Local recurrence and metastases may not appear until 10-15 years after the initial treatment [8] . When it recurs, destructive behavior has also been reported [8] .…”

Section: Discussionmentioning

confidence: 99%

“…Local recurrence and metastases may not appear until 10-15 years after the initial treatment [8] . When it recurs, destructive behavior has also been reported [8] . The diffi culty in treating recurrent ACC involving the skull base has led investigators to consider additional treatments beyond conventional surgery and radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

Stereotactic Radiosurgery as a Salvage Treatment for Recurrent Skull Base Adenoid Cystic Carcinoma

Mori

Kobayashi

Kida

et al. 2005

Stereotact Funct Neurosurg

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Twelve patients (15 lesions) with recurrent skull base adenoid cystic carcinoma (ACC) were treated by Gamma Knife stereotactic radiosurgery (SRS). The tumor volume ranged from 2 to 103 ml (median 15 ml). Treatment was prescribed at the 40–60% isodose line and ranged from 10 to 18 Gy (median: 13.0 Gy). The median follow-up period was 18 months (range 3–55). Six patients were alive and 6 dead at the end of the follow-up period. Only 1 patient died from local tumor recurrence. Ten among 15 tumors treated by SRS decreased in size until the end of the follow-up period or the patients’ death. Three remained unchanged in size. Two tumors initially regressed but then increased in size. In selected patients with recurrent skull base ACC, SRS can be considered as a salvage treatment with good local control.

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“…Although the use of primary radiation therapy in the treatment of tracheal adenoid cystic carcinoma has never been analyzed prospectively, previous studies and our observation indicate significant radiosensitivity of this tumor and suggest a putative role of radiotherapy in its managment. In analogy, for adenoid cystic carcinoma of the head and neck, primary radiotherapy apparently offers high likelihood of loco-regional control for locally advanced, unresectable or surgically inaccessible tumors [15, 16]. …”

Section: Discussionmentioning

confidence: 99%

Successful Primary Radiation Therapy of Adenoid Cystic Carcinoma of the Lung

Müller¹,

Stockamp²,

Schnabel

2000

Oncology

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Adenoid cystic carcinoma is a distinctive malignant neoplasm generally arising from minor salivary glands, that arises infrequently as a primary tumor in the lung. Surgery has been considered the primary treatment, with radiotherapy generally utilized as adjuvant or palliative treatment. We report a patient in whom primary radiotherapy was sucessfully applied to treat adenoid cystic carcinoma involving the distal trachea, carina, and both main stem bronchi. A total dose of 66 Gy was delivered in 2-Gy fractions over a 7-week period. Clinically and histologically complete remission was achieved without evidence of disease during a 27-month follow up.

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Analysis of adenoid cystic carcinoma treated by radiotherapy

Cited by 26 publications

References 14 publications

Adenoid Cystic Carcinoma of the Skull Base

Adenoid Cystic Carcinoma of the Skull Base

Stereotactic Radiosurgery as a Salvage Treatment for Recurrent Skull Base Adenoid Cystic Carcinoma

Successful Primary Radiation Therapy of Adenoid Cystic Carcinoma of the Lung

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