Analysis of ABH antigens in erythrocytes after ABO-Incompatible bone marrow transplantation.

Kishino, Koji; Muroi, Kazuo; Nakaki, Yoko; Otuki, Ikuko; Ojima, Saeko; Watanabe, Kazue; Obata, Takashi; Sugano, Naoko; Onozaki, Fumiko; Nagashima, Takahiro; Kawano, Chizuru; Watari, Kiyoshi; Iwamoto, Sadahiko; Ozawa, Keiya

doi:10.3925/jjtc1958.48.335

Cited by 3 publications

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“…Previous studies, including one from de Vooght et al (5), reported that recipient-type ABH antigen can be detected on the surface of RBCs after ABO-incompatible HSCT even after complete donor-type chimerism was confirmed. Kishino et al (4) reported that RBCs which express recipient-type ABH antigen can be detected after ABO-incompatible HSCT, because the recipient's ABH antigen which was produced by the recipient's mucous cells or gastrointestinal cells can persist (6). These antigens are considered to shed into the intestinal lumen, and thereafter they are digested, absorbed and transported to the serum (7)(8)(9).…”

Section: Discussionmentioning

confidence: 99%

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Persistent Expression of Recipient-type ABH Antigen after ABO-incompatible Allogeneic Hematopoietic Stem Cell Transplantation

et al. 2022

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In general, the recipient's ABO blood type changes to the donor's ABO blood type after ABOincompatible allogeneic hematopoietic stem cell transplantation (HSCT). However, we experienced a 26-yearold male with acute myelogenous leukemia (AML) who underwent ABO-incompatible HSCT twice and persistently showed his original blood type even after demonstrating complete donor-type chimerism. Based on the results of various examinations, we considered that the antigen of the recipient's original blood type persistently synthesized in the recipient's non-hematopoietic organs was secreted and adsorbed on the surface of donor-derived RBCs. We should therefore perform detailed examinations to determine the precise blood type after ABO-incompatible HSCT.

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Section: Discussionmentioning

confidence: 99%

“…To confirm our hypothesis, we performed an adsorption-elution study ( 4 ) in the following way. A healthy donor's type O RBCs were mixed with the plasma of this patient, and stored overnight at 4°C.…”

Section: Case Reportmentioning

confidence: 90%