Analysis of 3D multi‐layer microfluidic gradient generator

Ha, Jang Ho; Kim, Tae Hyeon; Lee, Jong Min; Ahrberg, Christian D.; Chung, Bong Geun

doi:10.1002/elps.201600443

Cited by 11 publications

(7 citation statements)

References 43 publications

(43 reference statements)

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“…Numerous experimental research endeavors have been devoted to this topic, and valuable information has been provided [13][14][15][16][17]. However, the results are often casedependent.…”

Section: Introductionmentioning

confidence: 99%

Electrophoresis of a highly charged fluid droplet in dilute electrolyte solutions: Analytical Hückel‐type solution

et al. 2022

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An analytical formula is presented here for the electrophoresis of a dielectric or perfectly conducting fluid droplet with arbitrary surface potentials suspended in a very dilute electrolyte solution. In other words, when the Debye length (κ −1 ) is very large, or κa≪1, where κ is the electrolyte strength and a stands for the droplet radius. This formula can be regarded as an extension of the famous Hückel solution valid for weakly charged rigid particles to arbitrarily charged fluid droplets. The formula reduces successfully to the ones obtained by Booth for a dielectric droplet, and Ohshima for a perfectly conducting droplet, both under Debye-Hückel approximation valid for weakly charged droplets. Moreover, the formula is valid for a gas bubble and a rigid solid particle as well. Classic results obtained by Hückel for a rigid particle are reproduced as well. We found that for a dielectric droplet, the more viscous the droplet is, the faster it moves regardless of its surface potential, contrary to the intuition based on the purely hydrodynamic consideration. For a perfectly conducting liquid droplet, on the other hand, the situation is reversed: The less viscous the droplet is, the faster it moves. The presence or absence of the spinning electric driving force tangent to the droplet surface is found to be responsible for it. As a result, an axisymmetric exterior vortex flow surrounding the droplet is always present for a dielectric liquid droplet, and never there for a conducting liquid droplet.

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“…Numerous experimental research endeavors have been devoted to this topic, and valuable information has been provided [13][14][15][16][17]. However, the results are often casedependent.…”

Section: Introductionmentioning

confidence: 99%

Electrophoresis of a highly charged fluid droplet in dilute electrolyte solutions: Analytical Hückel‐type solution

et al. 2022

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“…The microfluidic device was fabricated using a SU‐8 photolithography process as mentioned previously . Briefly, a photomask was designed using AutoCAD (Autodesk, USA).…”

Section: Methodsmentioning

confidence: 99%

Micropillar‐based microfluidic device to regulate neurite networks of uniform‐sized neurospheres

et al. 2018

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The inability of neurons to undergo mitosis renders damage to the central or peripheral nervous system. Neural stem cell therapy could provide a path for treating the neurodegenerative diseases. However, reliable and simple tools for the developing and testing neural stem cell therapy are still required. Here, we show the development of a micropillar-based microfluidic device to trap the uniform-sized neurospheres. The neurospheres trapped within micropillar arrays were largely differentiated into neuronal cells, and their neurite networks were observed in the microfluidic device. Compared to conventional cultures on glass slides, the neurite networks generated with this method have a higher reproducibility. Furthermore, we demonstrated the effect of thapsigargin on the neurite networks in the microfluidic device, demonstrating that neural networks exposed to thapsigargin were largely diminished and disconnected from each other. Therefore, this micropillar-based microfluidic device could be a potential tool for screening of neurotoxins.

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“…Microfluidic system design is particularly important. Ha et al [26] developed a simple 3D multilayer microfluidic gradient generator with the main channel orthogonal to the vertical side microchannels. Rismanian et al [27] regarded the dendritic concentration gradient generator as a structure composed of T-shaped micromixers, defined a dimensionless parameter to solve the minimum microchannel constant.…”

Section: Introductionmentioning

confidence: 99%

“…Ha et al. [26] developed a simple 3D multilayer microfluidic gradient generator with the main channel orthogonal to the vertical side microchannels. Rismanian et al.…”

Section: Introductionmentioning

confidence: 99%

An embedded obstacle type micromixer‐concentration gradient generator based on capillary driven

Huang,

Wu,

Wang

et al. 2023

Electrophoresis

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An embedded obstacle‐type micromixer‐concentration gradient generator based on capillary self‐driven is proposed and studied. Herringbone structure (HS) for mixing and palisade‐shape small channels at the outlet are designed in the device (named HS). Simulation and experimentation are done to study the liquid mixing efficiency in the small channels and concentration gradient at the outlet, and the experimental results agree with the simulation results. For three cases of liquid dripping (sequential, reverse, and delayed drippings), mixing analysis shows that the mixing efficiency increases along both mixing channel and palisade length, and is high in the middle small channel of the palisade‐shape area and low on both sides. An obvious concentration gradient at the outlet can form compared with the device without the palisade‐shape area. Finally, water pH value detection is done as one of the applications of HS. This study can provide guidance for the application of HS in biochemical detection, cell research, drug screening, etc. based on the capillary‐driven effect.

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Analysis of 3D multi‐layer microfluidic gradient generator

Cited by 11 publications

References 43 publications

Electrophoresis of a highly charged fluid droplet in dilute electrolyte solutions: Analytical Hückel‐type solution

Electrophoresis of a highly charged fluid droplet in dilute electrolyte solutions: Analytical Hückel‐type solution

Micropillar‐based microfluidic device to regulate neurite networks of uniform‐sized neurospheres

An embedded obstacle type micromixer‐concentration gradient generator based on capillary driven

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