Analysis of 2-Week Data from Two Randomized, Controlled Trials Conducted in Subjects with Frequent Heartburn Treated with Esomeprazole 20 mg

Katz, Philip O.; Moigne, Anne Le; Pollack, Charles V.

doi:10.1016/j.clinthera.2017.03.015

Cited by 1 publication

(1 citation statement)

References 23 publications

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“…Analysis have demonstrated that PPIs are the most prescribed drug class with a consistent therapeutic effect in controlling typical symptoms (heartburn and regurgitation) and healing of esophagitis when compared to placebo. This analysis included 11 controlled randomized studies (35)(36)(37)(38)(39) that analyzed 5,396 patients, comparing 2,944 patients on PPI treatment with 2,452 patients on placebo. PPI treatment increased the symptom resolution rate by 22% (95%CI 19-26%) compared to placebo.…”

Section: Recommendationmentioning

confidence: 99%

Brazilian Clinical Guideline for the Therapeutic Management of Gastroesophageal Reflux Disease (Brazilian Federation of Gastroenterology, Fbg)

MORAES-FILHO,

DOMINGUES,

CHINZON

2024

Arq. Gastroenterol.

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Background: Gastroesophageal Reflux Disease (GERD) is a prevalent condition in Brazil, affecting 12% to 20% of the urban population, with significant implications for patient quality of life and potential for complications. Objective: This paper focuses on the recent update of the Brazilian guidelines for GERD, a necessary revision due to advancements in knowledge and practice since the last publication over a decade ago. The update pays particular attention to the role and safety of proton pump inhibitors (PPIs), acknowledging the growing concerns about their long-term use, adverse events, and overprescription. Methods: The methodology of the guideline update involved an extensive literature review in multiple languages (English, French, Italian, Spanish, and Portuguese), drawing from major databases such as Medline, Embase, and SciELO-Lilacs. Results: This comprehensive approach resulted in a carefully curated selection of studies, systematic reviews, and meta-analyses, specifically focusing on PPIs and other therapeutic strategies for GERD. The updated guidelines are presented in a user-friendly question-and-answer format, adhering to the PICO system (Population, Intervention, Comparison, Outcomes) for clarity and ease of interpretation. The recommendations are supported by robust scientific evidence and expert opinions, enhancing their practical applicability in clinical settings. To ensure the reliability and clarity of the recommendations, the GRADE system (Grading of Recommendations Assessment, Development, and Evaluation) was employed. This system categorizes the strength of recommendations as strong, weak, or conditional and classifies evidence quality as high, moderate, low, or very low. These classifications provide insight into the confidence level of each recommendation and the likelihood of future research impacting these guidelines. Conclusion: The primary aim of these updated guidelines is to offer practical, evidence-based advice for the management of GERD in Brazil, ensuring that healthcare professionals are equipped with the latest knowledge and tools to deliver optimal patient care.

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