Analysis of 16 phthalic acid esters in food simulants from plastic food contact materials by <scp>LC</scp>‐<scp>ESI</scp>‐<scp>MS</scp>/<scp>MS</scp>

Li, Xiaojing; Xiong, Wei; Hua, Lu; Zhuo, Liyang; Lv, Shuiyuan; Tang, Xi; Chen, Minshi; Zou, Zhexiang; Lin, Zhenyu; Qiu, Bin

doi:10.1002/jssc.201200689

Cited by 30 publications

(24 citation statements)

References 20 publications

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“…While the migration phenomenon in plastics has already been studied extensively (Simoneau et al 2011(Simoneau et al , 2012Yang et al 2011;Castillo et al 2013;Li et al 2013;Bittner et al 2014;Kirchnawy et al 2014;Maiolini et al 2014), the present study complements previous findings by using a broader scope for the identification of chemicals originating from plastics. Therefore, the principal aim of this study was to detect migrants from the alternative plastic materials currently used for baby bottles.…”

supporting

confidence: 83%

Development and application of a non-targeted extraction method for the analysis of migrating compounds from plastic baby bottles by GC-MS

Onghena

Hoeck

Vervliet

et al. 2014

Food Additives & Contaminants: Part A

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In 2011, the European Union prohibited the production of polycarbonate (PC) baby bottles due to the toxic effects of the PC monomer bisphenol-A. Therefore, baby bottles made of alternative materials, e.g. polypropylene (PP) or polyethersulphone (PES), are currently marketed. The principal aim of the study was the identification of major compounds migrating from baby bottles using a liquid-liquid extraction followed by GC/MS analysis. A 50% EtOH in water solution was selected as a simulant for milk. After sterilisation of the bottle, three migration experiments were performed during 2 h at 70°C. A non-targeted liquid-liquid extraction with ethyl acetate-n-hexane (1:1) was performed on the simulant samples. Identification of migrants from 24 baby bottles was done using commercially available WILEY and NIST mass spectra libraries. Differences in the migrating compounds and their intensities were observed between the different types of plastics, but also between the same polymer from a different producer. Differences in the migration patterns were perceived as well between the sterilisation and the migrations and within the different migrations. Silicone, Tritan™ and PP exhibited a wide variety of migrating compounds, whereas PES and polyamide (PA) showed a lower amount of migrants, though sometimes in relatively large concentrations (azacyclotridecan-2-one up to 250 µg kg⁻¹). Alkanes (especially in PP bottles), phthalates (dibutylphthalate in one PP bottle (±40 µg kg⁻¹) and one silicone bottle (±25 µg kg⁻¹); diisobutylphthalate in one PP (±10 µg kg⁻¹), silicone (up to ±80 µg kg⁻¹); and Tritan™ bottle (±30 µg kg⁻¹)), antioxidants (Irgafos 168, degradation products of Irganox 1010 and Irganox 1076), etc. were detected for PP, silicone and Tritan™ bottles. Although the concentrations were relatively low, some compounds not authorised by European Union Regulation No. 10/2011, such as 2,4-di-tert-butylphenol (10-100 µg kg⁻¹) or 2-butoxyethyl acetate (about 300 µg kg⁻¹) were detected. Migrating chemicals were identified as confirmed (using a standard) or as tentative (further confirmation required).

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supporting

confidence: 83%

Development and application of a non-targeted extraction method for the analysis of migrating compounds from plastic baby bottles by GC-MS

Onghena

Hoeck

Vervliet

et al. 2014

Food Additives & Contaminants: Part A

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“…The detection of PAEs is generally performed by GC or HPLC. HPLC–UV is one of the commonly used techniques for determination of PAEs followed by GC–MS , GC with flame ionization detection (FID) , and HPLC–MS .…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of seven phthalic acid esters in beverages using ultrasound and vortex-assisted dispersive liquid-liquid microextraction followed by high-performance liquid chromatography

2014

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A sensitive, rapid, and simple high-performance liquid chromatography with UV detection method was developed for the simultaneous determination of seven phthalic acid esters (dimethyl phthalate, dipropyl phthalate, di-n-butyl phthalate, benzyl butyl phthalate, dicyclohexyl phthalate, di-(2-ethylhexyl) phthalate, and di-n-octyl phthalate) in several kinds of beverage samples. Ultrasound and vortex-assisted dispersive liquid-liquid microextraction method was used. The separation was performed using an Intersil ODS-3 column (C18 , 250 × 4.6 mm, 5.0 μm) and a gradient elution with a mobile phase consisting of MeOH/ACN (50:50) and 0.2 M KH2 PO4 buffer. Analytes were detected by a UV detector at 230 nm. The developed method was validated in terms of linearity, limit of detection, limit of quantification, repeatability, accuracy, and recovery. Calibration equations and correlation coefficients (> 0.99) were calculated by least squares method with weighting factor. The limit of detection and quantification were in the range of 0.019-0.208 and 0.072-0.483 μg/L. The repeatability and intermediate precision were determined in terms of relative standard deviation to be within 0.03-3.93 and 0.02-4.74%, respectively. The accuracy was found to be in the range of -14.55 to 15.57% in terms of relative error. Seventeen different beverage samples in plastic bottles were successfully analyzed, and ten of them were found to be contaminated by different phthalic acid esters.

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“…While the migration phenomenon in plastics has already been studied extensively Yang et al 2011;Li et al 2013;Castillo et al 2013;Kirchnawy et al 2014;Maiolini et al 2014), the present study complements previous findings by using a broader scope for the identification of chemicals originating from plastics. Therefore, the principal aim of this study was to detect migrants from the alternative polymer materials currently used for baby bottles.…”

Section: Introductionsupporting

confidence: 71%

Study of the possible migration risks of food contact materials for children under 3 years

Onghena¹

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Analysis of 16 phthalic acid esters in food simulants from plastic food contact materials by LC‐ESI‐MS/MS

Cited by 30 publications

References 20 publications

Development and application of a non-targeted extraction method for the analysis of migrating compounds from plastic baby bottles by GC-MS

Development and application of a non-targeted extraction method for the analysis of migrating compounds from plastic baby bottles by GC-MS

Simultaneous determination of seven phthalic acid esters in beverages using ultrasound and vortex-assisted dispersive liquid-liquid microextraction followed by high-performance liquid chromatography

Study of the possible migration risks of food contact materials for children under 3 years

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