Analysis of 135 Autopsy Eyes for Ocular Involvement in Leukemia

Leonardy, Nicholas J.; Rupani, Mahendra; Dent, Georgette A.

doi:10.1016/s0002-9394(14)74610-0

Cited by 112 publications

(74 citation statements)

References 33 publications

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“…5 Although significant CLL complications have been reported, the lack of consistent association with disease stage or haematological parameters would make targeted screening difficult. 15,16 As the prevalence of complications in this study is low, we do not believe that routine screening for ocular complications is justified.…”

Section: Eyementioning

confidence: 72%

The prevalence of ocular disease in chronic lymphocytic leukaemia

McKibbin

Burton

2003

Eye

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Aim Previous surveys of ocular disease in leukaemia patients have shown the retina, choroid, and orbit as the most commonly involved sites. Depending on the type of leukaemia and the study design, the prevalence of ocular disease in leukaemia varies from 30 to 90%. Although chronic lymphocytic leukaemia (CLL) is the most common leukaemia in Western countries, the prevalence of ocular disease in CLL is not known. The aim of this prospective study was to estimate the prevalence of ocular disease in CLL. Patients and Methods All CLL patients attending either a teaching or district general hospital haematology clinic were invited to undergo a full eye examination. The clinical stage of the CLL (Binet) at the time of the eye examination and the most recent full blood count (FBC) indices were recorded for each patient. Results Over 6 months, 25 patients with an average age of 65 were recruited. A total of 18 patients had Binet stage A disease, three had stage B, and four stage C. The mean FBC indices at the time of examination were haemoglobin 13.5 g/dl, white cell count 37.4 Â 10 9

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Section: Eyementioning

confidence: 72%

The prevalence of ocular disease in chronic lymphocytic leukaemia

McKibbin

Burton

2003

Eye

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“…In contrast, Karesh et al (1987) observed that the number of circulating leucocytes was unrelated to the presence of haemorrhages with or without white centres. The autopsy study by Leonardy et al (1990) showed a highly significant correlation between ocular leukaemic cell infiltration and agonal white blood cell counts; in a number of cases, leukaemic cells were seen migrating in choroidal vessels or infiltrating perivascularly. It is probable that this mechanism may explain the role of a high white blood cell count in the pathogenesis of retinal haemorrhages in these patients.…”

Section: Discussionmentioning

confidence: 97%

Retinopathy in acute leukaemia at initial diagnosis: correlation of fundus lesions and haematological parameters

Reddy

Jackson

2003

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To determine the prevalence of retinal changes in newly diagnosed acute leukaemia patients, and to establish the relationship between retinal lesions and haematological parameters in these patients. Methods: A total of 127 patients with acute leukaemia (myeloid and lymphoid), of both genders, aged between 13 and 77 years, were examined by an ophthalmologist for retinal changes using direct/indirect ophthalmoscopy within 2 days of diagnosis before starting chemotherapy. Results: Retinal lesions were seen in 62 cases (49%), with intraretinal haemorrhages being the most common lesion (42%). A high white blood cell count was significantly associated with intraretinal haemorrhages (p = 0.04) and white-centred haemorrhages (p = 0.001), while a low platelet count was significantly associated with intraretinal haemorrhages (p = 0.03) in acute myeloid leukaemia patients. Conclusions: A high white blood cell count may be considered as important as a low platelet count in the pathogenesis of leukaemic retinopathy.

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“…7 The reported prevalence of ocular involvement in leukaemia ranges from 9% to as high as 90%. 8,9 This divergent variation in results may imply the transient nature of leukemic ocular findings, which may be waxing and waning with time and treatment. It may also be due to the varied study designs and study centres.…”

Section: Discussionmentioning

confidence: 99%

Ophthalmic Manifestations In Patients of Acute Leukaemia Presenting to A Tertiary Care Centre In Western Rajasthan

Kochar¹

2018

DJO

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Analysis of 135 Autopsy Eyes for Ocular Involvement in Leukemia

Cited by 112 publications

References 33 publications

The prevalence of ocular disease in chronic lymphocytic leukaemia

The prevalence of ocular disease in chronic lymphocytic leukaemia

Retinopathy in acute leukaemia at initial diagnosis: correlation of fundus lesions and haematological parameters

Ophthalmic Manifestations In Patients of Acute Leukaemia Presenting to A Tertiary Care Centre In Western Rajasthan

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