Analysis, fate and effects of the antibiotic sulfadiazine in soil ecosystems

Schauss, Kristina; Focks, Andreas; Heuer, Holger; Kotzerke, Anja; Schmitt, Heike; Thiele‐Bruhn, Sören; Smalla, Kornelia; Wilke, Berndt‐Michael; Matthies, Michael; Amelung, Wulf; Klasmeier, Jörg; Schloter, Michael

doi:10.1016/j.trac.2009.02.009

Cited by 104 publications

(74 citation statements)

References 58 publications

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“…These effects include: -contamination of ground and sub-surface waters and soils; -phylogenetic structure alteration and resistance expansion; -damage to the microbial community and to terrestrial, as well as aquatic ecosystems functions; and -adverse health effects in humans, plants and livestock (Mojica and Aga, 2011). In Europe, complexes of tetracyclines (TCs) and sulfonamides (SAs) are commonly utilized as veterinary antibiotics (García-Galán et al, 2008;Schauss et al, 2009). Residues of such pharmaceuticals have already been discovered in soils in concentrations up to 300 ng g 1 for tetracyclines and 11 ng g 1 for sulfonamides Höper et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Impact of chlortetracycline and sulfapyridine antibiotics on soil enzyme activities

Ali¹,

Lakzian²,

Datta³

et al. 2017

International Agrophysics

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Pharmaceutical antibiotics are frequently used in the livestock and poultry industries to control infectious diseases. Due to the lack of proper guidance for use, the majority of administrated antibiotics and their metabolites are excreted to the soil environment through urine and feces. In the present study, we used chlortetracycline and sulfapyridine antibiotics to screen out their effects on dehydrogenase, alkaline phosphatase and urease activity. Factorial experiments were conducted with different concentrations of antibiotic (0, 10, 25 and 100 mg kg−1 of soil) mixed with soil samples, and the enzyme activity was measured at intervals of 1, 4 and 21 days. The results show that the chlortetracycline and sulfapyridine antibiotics negatively affect the dehydrogenase activity, but the effect of sulfapyridine decreases with time of incubation. Indeed, sulfapyridine antibiotic significantly affect the alkaline phosphatase activity for the entire three-time interval, while chlortetracycline seems to inhibit its activity within 1 and 4 days of incubation. The effects of chlortetracycline and sulfapyridine antibiotics on urease activity appear similar, as they both significantly affect the urease activity on day 1 of incubation. The present study concludes that chlortetracycline and sulfapyridine antibiotics have harmful effects on soil microbes, with the extent of effects varying with the duration of incubation and the type of antibiotics used.

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Section: Introductionmentioning

confidence: 99%

Impact of chlortetracycline and sulfapyridine antibiotics on soil enzyme activities

Ali¹,

Lakzian²,

Datta³

et al. 2017

International Agrophysics

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show abstract

“…In addition to protecting human and animal health (Schauss et al, 2009), antibiotics are also used as growth promoters in animals (Kemper, 2008). In China, it has been estimated that the annual usage of raw antibiotic materials is about 180,000 tons (including health and agricultural use).…”

Section: Introductionmentioning

confidence: 99%

Occurrence and distribution of antibiotics in the Beibu Gulf, China: Impacts of river discharge and aquaculture activities

Zheng

Zhang

Wang

et al. 2012

Marine Environmental Research

201

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“…Therefore, sulfonamides in the environment may impact soil health by changing microbial activity patterns and the kinetics of important turnover processes (6,25,48). Although changes in turnover rates have been reported for some microbial processes (e.g., see reference 24), a number of studies in the last decade have shown that the influence of sulfonamides on microbes and their metabolic performance in bulk soil is relatively low (42). These findings have been explained by (i) the large microbial diversity in bulk soil systems and by possible mechanisms of functional redundancy (37), (ii) the relatively low activity of microbes in bulk soil that are nearing the dormancy state (40) in which microbes are not affected by sulfonamides, and (iii) the development of resistant populations by horizontal gene transfer (20).…”

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confidence: 99%

Effect of Sulfadiazine-Contaminated Pig Manure on the Abundances of Genes and Transcripts Involved in Nitrogen Transformation in the Root-Rhizosphere Complexes of Maize and Clover

Ollivier¹,

Kleineidam

Reichel

et al. 2010

Appl Environ Microbiol

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The antibiotic sulfadiazine (SDZ) can enter the environment by application of manure from antibiotictreated animals to arable soil. Because antibiotics are explicitly designed to target microorganisms, they likely affect microbes in the soil ecosystem, compromising important soil functions and disturbing processes in nutrient cycles. In a greenhouse experiment, we investigated the impact of sulfadiazine-contaminated pig manure on functional microbial communities involved in key processes of the nitrogen cycle in the rootrhizosphere complexes (RRCs) of maize (Zea mays) and clover (Trifolium alexandrinum). At both the gene and transcript level, we performed real-time PCR using nifH, amoA (in both ammonia-oxidizing bacteria and archaea), nirK, nirS, and nosZ as molecular markers for nitrogen fixation, nitrification, and denitrification. Sampling was performed 10, 20, and 30 days after the application. SDZ affected the abundance pattern of all investigated genes in the RRCs of both plant species (with stronger effects in the RRC of clover) 20 and 30 days after the addition. Surprisingly, effects on the transcript level were less pronounced, which might indicate that parts of the investigated functional groups were tolerant or resistant against SDZ or, as in the case of nifH and clover, have been protected by the nodules.

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Analysis, fate and effects of the antibiotic sulfadiazine in soil ecosystems

Cited by 104 publications

References 58 publications

Impact of chlortetracycline and sulfapyridine antibiotics on soil enzyme activities

Impact of chlortetracycline and sulfapyridine antibiotics on soil enzyme activities

Occurrence and distribution of antibiotics in the Beibu Gulf, China: Impacts of river discharge and aquaculture activities

Effect of Sulfadiazine-Contaminated Pig Manure on the Abundances of Genes and Transcripts Involved in Nitrogen Transformation in the Root-Rhizosphere Complexes of Maize and Clover

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