Analysis Dosage of Boron in BNCT with Simulation Method Using PHITS (Particle and Heavy Ion Transport Code System) Program

Abstract

Abstrak – Cancer is a dangerous disease which is one of the main causes of death in the world, which is 8.8 million deaths in 2015. A new method has been developed for the treatment of cancer with small side effects, Boron Neutron Capture Therapy (BNCT). BNCT is based on the ability of non-radioactive isotopes Boron-10 to capture thermal neutrons. Boron is the main key of the BNCT process wherein, radiation of cancer cells can be carried out selectively if the cancer contains high concentrations of boron. Boron doses in cancer cells cannot be measured directly, therefore artificial network methods are used to compute doses computationally, namely the Monte Carlo method with the Particle and Heavy Ion Transport Code System (PHITS) program. Boron dose used was 10, 20 and 30 ?g/g. It was found that the greater the boron dose the greater the number of neutrons absorbed. The results showed that the largest absorption dose occurred in the Gross Tumor Volume (GTV) area of ??7.7076E-10 Gy/cm2.
 Key words: Cancer, BNCT, Dose of Boron, PHITS.

Primary study of the relative and compound biological effectiveness model for boron neutron capture therapy based on nanodosimetry

“…Due to the toxicity of boron compounds, boron poisoning may occur in patients at specific boron concentrations. Clinical studies have indicated that concentrations ranging from 0 to 35 μg 10 B/g in tumor tissues do not induce toxicity 43 . Consequently, the α and β parameters of the mLNDM with 10 B concentrations of 0, 5, 10, 20, and 30 ppm are employed for simulating the survival curves of BNCT.…”

“…Clinical studies have indicated that concentrations ranging from 0 to 35 μg 10 B/g in tumor tissues do not induce toxicity. 43 Consequently, the α and β parameters of the mLNDM with 10 B concentrations of 0, 5, 10, 20, and 30 ppm are employed for simulating the survival curves of BNCT. Figure 7b showed the survival curves of V79 cells at 10 B concentrations ranging from 0 to 30 ppm as predicted by the mLNDM and LNDM.…”