Analysis and simulation of a plasmonic biosensor for hemoglobin concentration detection using noble metal nano-particles resonances

Heidarzadeh, Hamid

doi:10.1016/j.optcom.2019.124940

Cited by 39 publications

(12 citation statements)

References 48 publications

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“…Considering the graphene thickness of 9 nm in the structure, the 304.6% gain in sensitivity compared to non-graphene structure was obtained [ 21 ]. Also, plasmonic nano-structures with different shapes (of sphere, cubic, cylindrical) were proposed for hemoglobin concentration sensing [ 22 ]. The results indicated different resonance wavelengths for the three nano-particle shapes.…”

Section: Introductionmentioning

confidence: 99%

Sensitive Hemoglobin Concentration Sensor Based on Graphene-Plasmonic Nano-structures

2021

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In this paper, half-cylindrical-shaped rods are arranged in a row in order to form hemoglobin concentration sensors. The proposed structures can effectively detect hemoglobin concentrations in blood samples. Five individual structures based on graphene-plasmonic combinations are proposed and investigated. The proposed structures are made of different layers of Au, Ag, SiO 2 , and graphene. Different plates and cylindrical-shaped graphene layers are introduced in the structures to improve the functionality (absorption peak value and wavelength) of the absorber (sensor). Adding more Au layers strengthens the confinement of the incident electromagnetic waves and improves the absorption factor. Also, in the proposed structures, for improving the results, the effects of the chemical potential of graphene layers and “G” (graphene layer thicknesses) on the absorption peak and wavelength are considered. The final suggested structure indicates unity absorption peak and thus can be utilized in wide ranges of applications. As a refractive index bio-sensor, the structure is considered for detecting hemoglobin concentrations in blood samples which indicates a reasonable sensitivity factor of 570 nm/RIU.

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Section: Introductionmentioning

confidence: 99%

Sensitive Hemoglobin Concentration Sensor Based on Graphene-Plasmonic Nano-structures

2021

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“…They can be designed to be compact, rapid/real-time, very sensitive, and label-free detection devices [4,[15][16][17][18]. Optical transducers also present several different types of construction and operating principles, among which we may cite: Surface Plasmon Resonance (SPR) [19][20][21], Localized Surface Plasmon Resonance (LSPR) [22], Raman Spectroscopy [23], Resonators [24], and Interferometers [14,25]. In particular, one type of interferometric optical sensor has received a significant amount attention over the last decade: the multimode interferometric sensor.…”

Section: Introductionmentioning

confidence: 99%

High-Order Multimode Waveguide Interferometer for Optical Biosensing Applications

Isayama

Hernández-Figueroa

2021

Sensors

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A generalization of the concept of multimode interference sensors is presented here for the first time, to the best of our knowledge. The existing bimodal and trimodal sensors correspond to particular cases of those interference sensors. A thorough study of the properties of the multimode waveguide section provided a deeper insight into the behavior of this class of sensors, which allowed us to establish new criteria for designing more sensitive structures. Other challenges of using high-order modes within the sensing area of the device reside in the excitation of these modes and the interpretation of the output signal. To overcome these, we developed a novel structure to excite any desired high-order mode along with the fundamental mode within the sensing section, while maintaining a fine control over the power distribution between them. A new strategy to detect and interpret the output signal is also presented in detail. Finally, we designed a high-order sensor for which numerical simulations showed a theoretical limit of detection of 1.9×10−7 RIU, making this device the most sensitive multimode interference sensor reported so far.

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“…Plasmonic nanostructures able to control light in space smaller than the diffraction limit, have a widespread application in waveguides, detectors [1][2][3], solar cells [4][5][6][7][8], and lasers [9]. Based on the precise permeability function of metals, their optical properties are inherently dependent on the fluctuating behavior of electrons in the metal.…”

Section: Introductionmentioning

confidence: 99%

“…The overall quality factor or figure of merit (FoM) of the LSP-based nano-sensors sensing response is severely affected by the wide local plasmon resonance linewidth due to the large inherent absorption of general metals and the main radiation scattering contribution [22,23]. To increase the total FoM, some efforts have been made to enhance the refractive index sensitivity of individual plasmonic nanoparticles by optimizing their size and shape [24][25][26]. Recently, several new design principles have been proposed, including plasmonic hybridization [27], transformation optics [28], and subgroup decomposition [29], which are used to modify the resonance line shape and enhance the spectral contrast of individual metal nanodimers and nanoclusters.…”

Section: Introductionmentioning

confidence: 99%

Highly sensitive refractive index sensor by floating nano-particles in the solution for the detection of glucose/fructose concentration

Bahador

Heidarzadeh

2021

Preprint

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In this research, an optimum design for better usage of field resonance was proposed. More interaction of the field that formed around nano-particles with a solution which has refractive index variations substantially can increase the sensitivity of the plasmonic biosensors. More interaction could be provided by floating nano-particles in the solution. The proposed structure, which has peak plasmonic resonance, has better light sensing features in comparison to similar non-floating structures. While without floating nano-particle, sensitivity is 265.8 nm/RIU with the realization of the full floating nano-particles, the sensitivity of the structure with elliptic disc and circular disc nano-particles are 574.2 nm/RIU and 425 nm/RIU, respectively. FWHM (Full width at half maximum) of the structure with elliptic disc and circular disc nano-particles are 57.4 nm and 49.4 nm, respectively. In presence of meshed SiO2 network and pseudo-floating form, sensitivity and FWHM of the structure are 504 nm/RIU and 58.4 nm for elliptic discs and 372 nm/RIU and 49.9 nm for circular discs, respectively.

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Analysis and simulation of a plasmonic biosensor for hemoglobin concentration detection using noble metal nano-particles resonances

Cited by 39 publications

References 48 publications

Sensitive Hemoglobin Concentration Sensor Based on Graphene-Plasmonic Nano-structures

Sensitive Hemoglobin Concentration Sensor Based on Graphene-Plasmonic Nano-structures

High-Order Multimode Waveguide Interferometer for Optical Biosensing Applications

Highly sensitive refractive index sensor by floating nano-particles in the solution for the detection of glucose/fructose concentration

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