In the paper, the sensitivity of the processing parameters for the cutting force on the disc-mill cutter machining TC17 blisk-tunnel is studied. Firstly, based on response surface methodology (RSM), a quadratic regression model between the cutting force and the processing parameters (cutting speed, feed rate per tooth, and cutting height) was established. Then, the local sensitivity of each parameter for the cutting force was calculated using the regression model, and a sensitivity curve of single parameter was acquired. Stable and unstable regions of each parameter were obtained by analyzing the sensitivity curve. Final global sensitivity of the process parameters to the cutting force was computed using the Sobol index method. The main effect, total effect, and interactive effect indexes were acquired. The results suggested that the cutting force for the disc-mill cutter machining blisk-tunnel is sensitive to the cutting speed and the feed rate per tooth. There exists a remarkable interaction between the cutting speed, feed rate per tooth, and cutting height on the cutting force. The cutting speed with [30,50], feed rate per tooth with [0.02,0.065], and cutting height with [28,43] are stable regions for the cutting force.