Analysis and occurrence of estrogenic hormones and their glucuronides in surface water and waste water in The Netherlands

Belfroid, A.C.; Horst, Astrid van der; Vethaak, A.D.; Schäfer, Andrea; Rijs, G.B.J.; Wegener, J.W.M.; Cofino, W.P.

doi:10.1016/s0048-9697(98)00336-2

Cited by 659 publications

(414 citation statements)

References 5 publications

Supporting

Mentioning

366

Contrasting

Unclassified

Order By: Relevance

“…Neither E2 nor EE2 could be found in River Tiber and River Aniene (Italy, LODs: 10ng/L) (Patrolecco et al 2015). In Dutch surface waters both analytes were detected mostly under the limit of quantification (<0.1 ng/L) (Belfroid et al 1999). In river samples in the Paris area (France) 1.4 to 3.0 mean E2 and 1.1 to 2.9 mean EE2 was found (Cargouet et al 2004).…”

Section: Discussionmentioning

confidence: 96%

β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

Avar

Zrínyi²,

Maász

et al. 2016

Environ Sci Pollut Res

View full text Add to dashboard Cite

17β-estradiol (E2) and 17α-ethinyl estradiol (EE2), which are environmental estrogens have been determined with LC-MS in freshwater. Their sensitive analysis needs derivatisation and therefore is very hard to achieve in multiresidue screening. We analysed samples from all the large and some small rivers (River Danube, Drava, Mur, Sava, Tisza and Zala) of the Carpathian Basin and from Lake Balaton. Freshwater was extracted on solid phase and derivatised using dansyl-chloride. Separation was performed on a Kinetex XB-C18 column. Detection was achieved with a benchtop orbitrap mass spectrometer using targeted MS analysis for quantification. Limits of quantification were 0.05 ng/L (MS1) and 0.1 ng/L (MS/MS) for E2, and 0.001 ng/L (MS1) and 0.2 ng/L (MS/MS) for EE2. River samples contained n.d.-5.2 ng/L E2 and n.d.-0.68 ng/L EE2. Average levels of E2 and EE2 were 0.61 and 0.084 ng/L respectively in rivers, water courses and Lake Balaton together, but not counting city canal water. EE2 was less abundant, but it was still present in almost all of the samples. In beach water samples from Lake Balaton we measured 0.076-0.233 E2 and n.d.-0.133 EE2. A relative high amount of EE2 was found in river Zala (0.68 ng/L) and in Hévíz-Páhoki canal (0.52 ng/L), which are both in the catchment area of Lake Balaton (Hungary). HighlightsMethod is proposed for simultaneous determination of 17β-estradiol and 17α-ethinyl estradiol. Derivatization is necessary to reach low LOQ. Low ng/L presence of estrogens in selected European Rivers has been detected.

show abstract

Section: Discussionmentioning

confidence: 96%

β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

Avar

Zrínyi²,

Maász

et al. 2016

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

“…E2, E1, and EE2 analysis in water was carried out as described in Belfroid et al (12), with the exception that the quantification of the chromatograms was done with the internal deuterated standard of d4-17 -estradiol. For NP analysis in test medium, water was extracted according to the method described by De Voogt et al (13).…”

Section: Methodsmentioning

confidence: 99%

Comparison of in Vivo and in Vitro Reporter Gene Assays for Short-Term Screening of Estrogenic Activity

Legler

Zeinstra

Schuitemaker

et al. 2002

Environ. Sci. Technol.

185

130

View full text Add to dashboard Cite

CALUX assay, only o,p′-DDT demonstrated weak dose-related estrogenic activity in vivo. To determine if differences in reporter gene activity may be explained by differential affinity of (xeno)estrogens to human and zebrafish ERs, fulllength sequences of the zebrafish ER subtypes R, , and γ were cloned, and transactivation by (xeno)estrogens was compared to human ERR and ER . Using transiently transfected recombinant ER and reporter gene constructs, EE2 also showed relatively potent activation of zebrafish ERR and ER compared to human ERR and ER . Zebrafish ER and ERγ showed higher transactivation by (xeno)-estrogens relative to E2 than human ER .

show abstract

“…Picogram to nanogram per liter concentrations of estrogenic activity have been found throughout the aquatic environment, e.g. in wastewater, surface water, and sediment (Jobling et al 1998;Belfroid et al 1999;Bolz et al 2001;de Alda and Barcelo 2001;Petrovic et al 2002;Houtman et al 2004b;Peck et al 2004;Cespedes et al 2005;Houtman et al 2006a;Morteani et al 2006). …”

Section: Endocrine Disrupting Compoundsmentioning

confidence: 99%

Emerging contaminants in surface waters and their relevance for the production of drinking water in Europe

Houtman

2010

Journal of Integrative Environmental Sciences

196

View full text Add to dashboard Cite

An increasing part of drinking water in Europe is prepared from surface water. At the same time, a growing number of emerging contaminants is being discovered in surface water. This review provides an overview of classes of emerging contaminants nowadays detected in the aquatic environment that are of relevance for drinking water production. These comprise e.g. endocrine disrupting compounds, such as hormones and compounds with hormone-like properties, pharmaceuticals, illicit and non-controlled drugs, sweeteners, personal care products, complexing agents, nanoparticles, perfluorinated compounds, flame retardants, pesticides, and fuel additives. The individual compounds are observed in concentrations that are generally considered too low to cause acute effects. Nevertheless, health effects due to long-term exposure to a mixture of low concentrations of all kinds of emerging contaminants cannot be excluded with current knowledge. Moreover, contamination of drinking water with man-made substances is considered unwanted in principle. The precautionary principle is used to motivate that prevention of emission of emerging contaminants into the environment is the preferred approach to safeguard sustainable drinking water production. In the mean time, extensive monitoring of the sources and development and application of advanced treatment techniques are used to prepare safe drinking water.

show abstract

Analysis and occurrence of estrogenic hormones and their glucuronides in surface water and waste water in The Netherlands

Cited by 659 publications

References 5 publications

β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

Comparison of in Vivo and in Vitro Reporter Gene Assays for Short-Term Screening of Estrogenic Activity

Emerging contaminants in surface waters and their relevance for the production of drinking water in Europe

Contact Info

Product

Resources

About