Analysis and modeling of swelling and erosion behavior for pure HPMC tablet

Chirico, Serafina; Dalmoro, Annalisa; Lamberti, Gaetano; Russo, Giuseppina; Titomanlio, G.

doi:10.1016/j.jconrel.2007.07.001

Cited by 66 publications

(42 citation statements)

References 12 publications

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“…In all drug delivery systems, as in the whole pharmacotherapy, the development of systems capable of predetermine the release profile of a drug is an important tool (22). In the present work, the release of zoledronate from SBA 15 materials has been modeled; to verify this prediction, SBA 15 materials have been loaded with the same bisphosphonate and release experiments have been carried out aiming to validate the model here proposed with experimental data.…”

Section: Introductionmentioning

confidence: 96%

Anti-Osteoporotic Drug Release from Ordered Mesoporous Bioceramics: Experiments and Modeling

et al. 2011

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Abstract. The release of a potent bone-resorption inhibitor such as zoledronate from a versatile drug delivery system such as SBA 15 has been modeled. The initial and boundary conditions have been defined, together with the system parameters, including the determination of equilibrium and transport parameters. Additionally, the experimental model of the same system has been observed to validate the prediction here developed. This approach represents a powerful tool for the designing of mesoporous implantable drug delivery systems because their release kinetics can be predicted in advance, and this leads to a considerable time and resources saving.

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Section: Introductionmentioning

confidence: 96%

Anti-Osteoporotic Drug Release from Ordered Mesoporous Bioceramics: Experiments and Modeling

et al. 2011

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“…The detailed knowledge of the transport phenomena involved is the key prerequisite in developing a reliable mathematical model useful for the prediction of the release kinetics as function of the formulation parameters or of the external conditions [55]; on the other hand, the availability of a reliable mathematical model of the drug release process could allow to theoretically predict the drug release profile for a given, newly designed, pharmaceutical product, reducing the number of necessary experiments and facilitating the development of new pharmaceuticals [11].…”

Section: Phenomenology Of Drug Release From Swelling Hydrogelsmentioning

confidence: 99%

“…On these bases, a nondestructive test to determine the water mass fraction along the radial profile of a pure HPMC tablet was developed by Chirico et al [55]. Being the tablet composed only by the polymer, this work was focused only on the water penetration inside the matrix, and the tablet was confined between two glass slides to limit the water uptake only in the radial surface.…”

Section: Image Analysis Techniquementioning

confidence: 99%

“…Inspired by Siepmann's work, in the 2007, Chirico et al [55] developed a 1D model to describe the hydration of pure HPMC tablets confined between two glass slabs ( Figure 9). Considering that the main transport phenomenon is the pseudo-diffusion of water from the medium (r > R ( t ) ) into the tablet through the radial direction (Table 3 equations ( …”

Section: Multicomponent Approach: Mass Transfermentioning

confidence: 99%

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Swellable Hydrogel-based Systems for Controlled Drug Delivery

Caccavo¹,

Cascone²,

Lamberti³

et al. 2016

Smart Drug Delivery System

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The controlled delivery of drugs can be effectively obtained using systems based on hydrogels. Tablets, to be orally administered, represent the simplest and the most traditional dosage systems based on hydrogel. Their formulation and preparation require to mix and to compress, in proper ratios, various excipients, including a swellable polymer and a drug. Carriers for controlled release systems are usually cross-linked polymers able to form hydrogels that show peculiar release mechanisms, where both diffusion and tablet swelling play important roles.When a dry swellable hydrogel-based matrix is immersed in a physiological fluid, this starts to penetrate inside the polymeric hydrophilic matrix. When a certain solvent concentration is reached, the polymeric chains unfold due to a glass-rubber transition, and a gel-like layer is formed. In the swollen region, the drug molecules can easily diffuse toward the outer dissolution medium, once they are dissolved. The polymer network became extremely hydrated where the swollen matrix is in contact with the outer medium, and processes like chain disentanglement take place, "eroding" the matrix.This chapter is focused on the analysis of the state of the art about the uses of carriers for controlled release systems composed by hydrogel-based matrices. This analysis has been performed studying in deep both the experimental and the modeling techniques which have been investigated over the years to characterize all the phenomena involved during the drug release.

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“…Polymers belonging to hydrophilic matrix systems, when exposed to an aqueous medium, does not disintegrate, but immediately after hydration develops a highly viscous gelatinous surface barrier which controls the drug release from the liquid penetration into the center of the matrix system (2). The semi synthetic polymers and synthetic polymers used for this purpose (3)(4)(5)(6) in combination with various drugs have been protected by end number of patents, thus there is always a search for new polymers to circumvent these patents in the pharmaceutical field. As the nature possesses much more plant exudates and gums to be explored, the research in this field had yielded many useful gums like acacia, tragacanth and karaya for the controlled drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

Rheological Characterization and Drug Release Studies of Gum Exudates of Terminalia catappa Linn

Kumar

Sasmal

Pal³

2008

AAPS PharmSciTech

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Abstract. The present study was undertaken to evaluate the gum exudates of Terminalia catappa Linn. (TC gum) as a release retarding excipient in oral controlled drug delivery system. The rheological properties of TC gum were studied and different formulation techniques were used to evaluate the comparative drug release characteristics. The viscosity was found to be dependent on concentration and pH. Temperature up to 60°C did not show significant effect on viscosity. The rheological kinetics evaluated by power law, revealed the shear thinning behavior of the TC gum dispersion in water. Matrix tablets of TC gum were prepared with the model drug dextromethorphan hydrobromide (DH) by direct compression, wet granulation and solid dispersion techniques. The dissolution profiles of the matrix tablets were compared with the pure drug containing capsules using the USP Basket apparatus with 500 ml phosphate buffer of pH 6.8 as a dissolution medium. The drug release from the compressed tablets containing TC gum was comparatively sustained than pure drug containing capsules. Even though all the formulation techniques showed reduction of dissolution rate, aqueous wet granulation showed the maximum sustained release of more than 8 h. The release kinetics estimated by the power law revealed that the drug release mechanism involved in the dextromethorphan matrix is anomalous transport as indicated by the release exponent n values. Thus the study confirmed that the TC gum might be used in the controlled drug delivery system as a release-retarding polymer.

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Analysis and modeling of swelling and erosion behavior for pure HPMC tablet

Cited by 66 publications

References 12 publications

Anti-Osteoporotic Drug Release from Ordered Mesoporous Bioceramics: Experiments and Modeling

Anti-Osteoporotic Drug Release from Ordered Mesoporous Bioceramics: Experiments and Modeling

Swellable Hydrogel-based Systems for Controlled Drug Delivery

Rheological Characterization and Drug Release Studies of Gum Exudates of Terminalia catappa Linn

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