Analysis and Isolation of Secondary Metabolites of Bipolarissorokiniana by Different Chromatography Techniques and the Spectrum of Their Biological Activity

Berestetskiy, Alexander; Dalinova, Anna; Dubovik, Vsevolod; Grigoryeva, E. N.; Kochura, Dmitry; Senderskiy, Igor V.; Смирнов, С. Н.; Степанычева, Е. А.; Turaeva, Saida

doi:10.1134/s0003683820050051

Cited by 6 publications

(6 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cochlioquinone N ( 1 ) had been isolated from Bipolaris sp. [ 27 ], while cochlioquinone A ( 2 ) had been found from Bipolaris and Cochliobolus genera, including B. sorokiniana [ 34 ], Bipolaris sp. [ 27 ], B. bicolor [ 35 ], Cochliobolus sp.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus Curvularia sp.

Suthiphasilp

Raksat

Maneerat

et al. 2021

JoF

View full text Add to dashboard Cite

Chemical investigation of the mycelia of the pathogenic fungus Curvularia sp. which was isolated from a leaf of Dactyloctenium aegyptium (crowfoot grass), resulted in the isolation of a new compound, curvulariahawadride (5), along with five known compounds (1–4, and 6). Their structures were determined on the basis of spectroscopic data, including 1D and 2D NMR and HRESIMS. The absolute configuration of 5 was established from experimental and calculated electronic circular dichroism (ECD). Compounds 1, 3, and 5 showed nitric oxide (NO) production inhibitory activity with IC50 values of 53.7, 32.8, and 12.8 µM, respectively. Compounds 2 and 4 showed significant cytotoxicity against lung cancer A549, colorectal cancer SW480, and leukemic K562 cells with an IC50 ranging value of 11.73 to 17.59 µM.

show abstract

Section: Resultsmentioning

confidence: 99%

Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus Curvularia sp.

Suthiphasilp

Raksat

Maneerat

et al. 2021

JoF

View full text Add to dashboard Cite

show abstract

“…The differences in the aphicidal activity of beauvericin may be explained by the variability of S. graminum populations. As mentioned above, some other fungal toxins of the genus, for example, diversolonic esters and chloromonilinic acid B, are more toxic than TeA, causing 70–80% mortality of S. graminum at a concentration of 1 mg/mL [ 9 , 63 ]. The insecticide thiacloprid from the group of neonicotinoids was significantly more toxic to grass aphids, with an LD 50 of approximately 210 µg/mL [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

Entomotoxic Activity of the Extracts from the Fungus, Alternaria tenuissima and Its Major Metabolite, Tenuazonic Acid

Salimova

Dalinova

Dubovik

et al. 2021

JoF

View full text Add to dashboard Cite

The study of fungal antibiotics in their competitive interactions with arthropods may lead to the development of novel biorational insecticides. Extracts of Alternaria tenuissima MFP253011 obtained using various methods showed a wide range of biological activities, including entomotoxic properties. Analysis of their composition and bioactivity allowed us to reveal several known mycotoxins and unidentified compounds that may be involved in the entomotoxic activity of the extracts. Among them, tenuazonic acid (TeA), which was the major component of the A. tenuissima extracts, was found the most likely to have larvicidal activity against Galleria mellonella. In the intrahaemocoel injection bioassay, TeA was toxic to G. mellonella and of Zophobas morio with an LT50 of 6 and 2 days, respectively, at the level of 50 µg/larva. Administered orally, TeA inhibited the growth of G. mellonella larvae and caused mortality of Acheta domesticus adults (LT50 7 days) at a concentration of 250 µg/g of feed. TeA showed weak contact intestinal activity against the two phytophages, Tetranychus urticae and Schizaphis graminum, causing 15% and 27% mortality at a concentration of 1 mg/mL, respectively. TeA was cytotoxic to the Sf9 cell line (IC50 25 µg/mL). Thus, model insects such as G. mellonella could be used for further toxicological characterization of TeA.

show abstract

“…The differences in aphicidal activity of beauvericin may be explained by variability of S. graminum populations. As mentioned above, some other fungal toxins of the genus, for example, diversolonic esters and chloromonilinic acid B, are more toxic than TeA causing 70-80% mortality of S. graminum at a concentration of 1 mg/mL [9,63]. The insecticide thiacloprid from the group of neonicotinoids was significantly more toxic to grass aphids with an LD50 of about 210 µg/mL [64].…”

Section: Entomotoxicity Of Tenuazonic Acidmentioning

confidence: 93%

Entomotoxic Activity of the Extracts from the Fungus, <em>Alternaria tenuissima</em> and Its Major Metabolite, Tenuazonic Acid

Salimova¹,

Dalinova²,

Dubovik³

et al. 2021

Preprint

View full text Add to dashboard Cite

Study of fungal antibiotics in their competitive interactions with arthropods may lead to development novel biorational insecticides. Extracts of Alternaria tenuissima MFP253011 obtained by various methods showed a wide range of biological activity, including entomotoxic properties. Analysis of their composition and bioactivity allowed to reveal several known mycotoxins and unidentified compounds that may be involved in entomotoxic activity of the extracts. Among them, tenuazonic acid (TeA), which was the major component of the A. tenuissima extracts, was found the most likely to have larvicidal activity against Galleria mellonella. In the intrahaemocoel injection bioassay, TeA was toxic to G. mellonella and of Zophobas morio with LT50 6 and 2 days, respectively, at the level of 50 µg/larva. Administered orally, TeA inhibited growth of G. mellonella larvae and caused mortality of Acheta domesticus imagines (LT50 7 days) at a concentration of 250 µg/g of feed. TeA showed weak contact-intestinal activity against the two phytophages, Tetranychus urticae and Schizaphis graminum, causing the 12 and 40% of mortality at a concentration of 1 mg/mL. TeA was cytotoxic to Sf9 cell line (IC50 25 µg/mL). Thus, model insect G. mellonella and cell line Sf9 could be used for a further toxicological characterization of TeA.

show abstract

Analysis and Isolation of Secondary Metabolites of Bipolarissorokiniana by Different Chromatography Techniques and the Spectrum of Their Biological Activity

Cited by 6 publications

References 35 publications

Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus Curvularia sp.

Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus Curvularia sp.

Entomotoxic Activity of the Extracts from the Fungus, Alternaria tenuissima and Its Major Metabolite, Tenuazonic Acid

Entomotoxic Activity of the Extracts from the Fungus, <em>Alternaria tenuissima</em> and Its Major Metabolite, Tenuazonic Acid

Contact Info

Product

Resources

About