Analysis and classification of droplet characteristics from atomizers using multifractal analysis

Godavarthi, Vedasri; Dhivyaraja, K.; Sujith, R. I.; Panchagnula, Mahesh V.

doi:10.1038/s41598-019-52596-6

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…Large particles (5–15 μm) were mainly deposited in the upper airways and trachea, intermediate-sized particles (3–5 μm) were tendency deposited in the bronchi and bronchioles, and small particles (≤ 3 μm) were flowed into the alveoli [ 29 ]. The aerosol characteristics were closely related to the device of atomizer, which depended on the design of pressure swirl, airblast and ultrasonic atomizers [ 30 ]. The ultrasonic atomizers operated at different frequencies, which were well with the median droplet size [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Sufentanil EC50 for endotracheal intubation with aerosol inhalation of carbonated lidocaine by ultrasonic atomizer

Zhou

et al. 2021

BMC Anesthesiol

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Background Nebulized lidocaine reduced stress response for endotracheal intubation. However, the impact of novel lidocaine aerosol inhalation for intubation by ultrasonic atomizer was unclear. Hence, we designed aerosol inhalation of lidocaine by ultrasonic atomizer, to seek whether the dosage of sufentanil for intubation could be less or not. Methods Intravenous injection of sufentanil started at 0.5 μg/kg, and sufentanil dosage was increased/decreased (step-size 0.05 μg/kg for sufentanil) using Dixon’s up and down method. The observation was terminated after 8 reflexes. Results The EC50 and EC95 of sufentanil with lidocaine by ultrasonic atomizer for intubation were found to be 0.232 μg/kg (95% CI: 0.187–0.270 μg/kg) and 0.447 μg/kg (95% CI: 0.364–0.703 μg/kg). 55.88% out of 34 patients showed hemodynamic index change < 20% of baseline during intubation. Conclusion Aerosol inhalation of lidocaine by ultrasonic atomizer reduced the dosage of sufentanil for endotracheal intubation. Lidocaine inhalation by ultrasonic atomizer for airway anesthesia with minimal dosage of sufentanil could be recommended, particularly in patients who need more stable hemodynamic changes or spontaneous respiration. Trial registration Chinese Registry of Central Trial, ChiCTR-IOR-17014198. Registered 28 December 2017.

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Section: Discussionmentioning

confidence: 99%

Sufentanil EC50 for endotracheal intubation with aerosol inhalation of carbonated lidocaine by ultrasonic atomizer

Zhou

et al. 2021

BMC Anesthesiol

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“…Large particles (5-15 µm) are mainly deposited in the upper airways and trachea, intermediate-sized particles (3-5 µm) has tendency to be deposited in the bronchi and bronchioles, and small particles (≤ 3 µm) are owed into the alveoli [24]. The aerosol characteristics are closely related to the device of atomizer,which depends on the design of pressure swirl, airblast and ultrasonic atomizers [25]. The ultrasonic atomizers operate at different frequencies, which are well with the median droplet size [26].…”

Section: Discussionmentioning

confidence: 99%

Sufentanil EC50 for Endotracheal Intubation with Aerosol Inhalation of Lidocaine

Xu¹,

Zhou²,

Ai³

et al. 2020

Preprint

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Background: Nebulized lidocaine combined with opioid drugs was a classical implementation for awake intubation or rigid bronchoscopy. In this study, aerosol inhalation of carbonated lidocaine combined with sufentanil was accomplished prior to induction of anesthesia, to dig out whether the dosage of sufentanil could less or not, and the sufentanil EC50 for endotracheal intubation under these drugs combination.Methods: Intravenous injection of sufentanil starting at 0.5 μg/kg. Then sufentanil dosages were increased/decreased (step-size 0.05 μg/kg for sufentanil) using Dixon and Massey up and down method in the next patient depending upon previous patient's response within 3 min after intubation. The observation was terminated after 8 reflexes. The hemodynamic indexes were recorded.Results: The EC50 and EC95 of sufentanil with aerosol inhalation of lidocaine for endotracheal intubation was found to be 0.232 μg/kg (95% CI: 0.187-0.270 μg/kg) and 0.447 μg/kg (95% CI: 0.364-0.703 μg/kg). 55.88% out of 34 patients showed hemodynamic index change <20% of baseline during endotracheal intubation.Conclusion: Aerosol inhalation of lidocaine could reduce the dosage of sufentanil for endotracheal intubation. The advantages in lidocaine inhalation for airway anesthesia by ultrasonic atomizer could be recommended in patients who need more stable hemodynamic changes.Trial registration: Chinese Registry of Central Trial, ChiCTR-IOR-17014198. Registered 28 December 2017, http://www.chictr.org.cn/showprojen.aspx?proj=22301

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“…There are diverse details that typify the spray formation, which are the technique and configuration of the atomization process, dimension and structure of the nozzle, experimental parameters, etc. [23]. Even though there are literature surveys on various atomization processes [24][25][26][27], the complexity of the technique, the possession of the atomizer on the droplet qualities, imprecision in computation strategies are still not well understood [28,29].…”

Section: Kinetics Of Liquid Jets and Sheetsmentioning

confidence: 99%

An Overview on Atomization and Its Drug Delivery and Biomedical Applications

2021

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Atomization is an intricate operation involving unstable and complex networks with rupture and fusion of liquid molecules. There are diverse details that typify the spray formation, which are the technique and configuration of the atomization process, dimension and structure of the nozzle, experimental parameters, etc. Ultimately, the process generates fine sprays from the bulk of a liquid. Some examples of atomization that we come across in our day-to-day life are antiperspirant or hair spray, shower head, garden sprinkler, or cologne mist. In this review paper we are briefly discussing the theoretical steps taking place in an atomization technique. The instabilities of the jet and sheet are explained to understand the underlying theory that breaks the jet or sheet into droplets. Different types of atomization processes based on the energy sources are also summarized to give an idea about the advantages and disadvantages of these techniques. We are also discussing the various biomedical applications of the electrohydrodynamic atomization and its potential to use as a drug delivery system. In short, this paper is trying to demonstrate the diverse applications of atomization to show its potency as a user friendly and cost-effective technique for various purposes.

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Analysis and classification of droplet characteristics from atomizers using multifractal analysis

Cited by 6 publications

References 37 publications

Sufentanil EC50 for endotracheal intubation with aerosol inhalation of carbonated lidocaine by ultrasonic atomizer

Sufentanil EC50 for endotracheal intubation with aerosol inhalation of carbonated lidocaine by ultrasonic atomizer

Sufentanil EC50 for Endotracheal Intubation with Aerosol Inhalation of Lidocaine

An Overview on Atomization and Its Drug Delivery and Biomedical Applications

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