Analysis, accumulation and central effects of trihalomethanes. I. bromoform†

Parra, Pilar; Martı́nez, Emili; Suñol, Cristina; Artigas, Francesc; Tusell, Josep Maria; Gelpl, E.; Albaigés, J.

doi:10.1080/02772248609357122

Cited by 7 publications

(2 citation statements)

References 23 publications

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“…Bromoform was not detected in any of the animal tissues, which is in line with other studies where A. taxiformis was included in the diet of ruminants [9,10]. Bromoform may be rapidly eliminated from animal tissue in rats, with levels already halved 30 min compared to 15 min after administration, and not detectable anymore after 1-4 h [23]. In the present study, the time of slaughter was 24 h after the last supply of seaweed mix, which may explain why CHBr 3 was not detected in animal tissues.…”

Section: Bromoform Excretion and Residuessupporting

confidence: 90%

Safety and Transfer Study: Transfer of Bromoform Present in Asparagopsis taxiformis to Milk and Urine of Lactating Dairy Cows

Muizelaar

Groot

Duinkerken

et al. 2021

Foods

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Enteric methane (CH4) is the main source of greenhouse gas emissions from ruminants. The red seaweeds Asparagopsis taxiformis (AT) and Asparagopsis armata contain halogenated compounds, including bromoform (CHBr3), which may strongly decrease enteric CH4 emissions. Bromoform is known to have several toxicological effects in rats and mice and is quickly excreted by the animals. This study investigated the transfer of CHBr3 present in AT to milk, urine, feces, and animal tissue when incorporated in the diet of dairy cows. Twelve lactating Holstein-Friesian dairy cows were randomly assigned to three treatment groups, representing the target dose (low), 2× target dose (medium), and 5× target dose (high). The adaptation period lasted seven days, and subsequently cows were fed AT for 22 days maximally. The transfer of CHBr3 to the urine at days 1 and 10 (10–148 µg/L) was found with all treatments. On day 1, CHBr3 was detected in the milk of most cows in the low and medium treatment groups (9.1 and 11 µg/L, respectively), and detected in the milk of one cow in the high treatment group on day 9 (35 µg/L). Bromoform was not detected in milk and urine at day 17, nor at concentrations above the detection limit in feces and collected animal tissues. Two animals (low) were sacrificed, and their rumen wall showed abnormalities. Upon histological examination, signs of inflammation became visible. Animals regularly refused the feed or distinctively selected against AT. In conclusion, within the confines of the present experiment, CHBr3 does not accumulate in animal tissue, but can be excreted in urine and milk.

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Section: Bromoform Excretion and Residuessupporting

confidence: 90%

Safety and Transfer Study: Transfer of Bromoform Present in Asparagopsis taxiformis to Milk and Urine of Lactating Dairy Cows

Muizelaar

Groot

Duinkerken

et al. 2021

Foods

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“…Chloroform was reported to cause cancer in experimental animals (Bull 1981). Other THMs, based on the structural similarity to chloroform, may be also classified as health hazard compounds (WHO 1984;Parra et al 1986). Accordingly, THMs in water supplies should be monitored closely so that measures may be taken to minimize or eliminate their presence whenever the concentration approache levels of concern.…”

mentioning

confidence: 99%

Detection and Quanification of Trihalomethanes in Drinking Water from Alexandria, Egypt

Hassan

Benfenati

Fanelli

1996

Bulletin of Environmental Contamination and Toxicology

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Tribrommethan [MAK Value Documentation in German language, 1993]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 19. Lieferung, Ausgabe 1993 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Angaben zur Pharmakokinetik Erfahrungen beim Menschen Tierexperimentelle Befunde Akute Toxizität Subchronische und chronische Toxizität Allergene Wirkung Reproduktions‐ und Teratogenitätsstudien Untersuchungen zu gentoxischen Wirkungen Untersuchungen zur kanzerogenen Wirkung Zur Frage eines MAK‐Wertes

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Analysis, accumulation and central effects of trihalomethanes. I. bromoform†

Cited by 7 publications

References 23 publications

Safety and Transfer Study: Transfer of Bromoform Present in Asparagopsis taxiformis to Milk and Urine of Lactating Dairy Cows

Safety and Transfer Study: Transfer of Bromoform Present in Asparagopsis taxiformis to Milk and Urine of Lactating Dairy Cows

Detection and Quanification of Trihalomethanes in Drinking Water from Alexandria, Egypt

Tribrommethan [MAK Value Documentation in German language, 1993]

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