Analyses of tissue, blood, and urine samples from a baboon gavaged with chrysotile and crocidolite asbestos

Hallenbeck, William H.; Markey, Donald R.; Dolan, David G.

doi:10.1016/0013-9351(81)90037-2

Cited by 27 publications

(25 citation statements)

References 9 publications

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“…Contrary to this, other studies (20)(21)(22) indicate that ingested fibers do not penetrate or migrate. In the present study, recovery of chrysotile fibrils, bundles, and clusters in kidney cortex of gavaged rats clearly shows that migration occurs, and it supports our previous findings of chrysotile asbestos recovery in kidney cortex of a baboon (12) and humans (23).…”

Section: Discussionmentioning

confidence: 66%

“…One gavage study (22) failed to demonstrate penetration and migration of ingested fibers due to contamination, resulting in fiber counts in the controls in the same range as the counts in test baboon blood and urine. Moreover, the detection limit of their methodology was low due to scanning of only 20 grid holes per sample and use of only one test animal.…”

Section: Discussionmentioning

confidence: 99%

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Accumulation of Ingested Asbestos Fibers in Rat Tissues over Time

Patel-Mandlik¹,

Millette²

1983

Environmental Health Perspectives

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With the use of the transmission electron microscope, asbestos fibers have been assessed in kidney cortex of four groups of rats previously exposed to intermediate-range feeding grade chrysotile asbestos. Newborn rats, from mothers gavaged with asbestos during pregnancy, were gavaged twice a week at the dose level of 50 mg/kg beginning at age day 7 until their natural death or sacrifice. The rats were divided into four groups by age: 0-200, 200-400, 400-600 and 600-800 days. Of the 20 rats comprising the four test groups, 17 were positive, average fiber recovery being 5.34 x 103/mg dry weight. Average fiber level in control tissues was 0.23 x 103/mg dry weight. Fiber recovery in tissues from control animals was shown to be significantly lower (p < 0.005) than that from test tissues. Test groups showed highly significant differences (p < 0.005) from each other in the fiber levels. Dose-response relationship was not significant (0.05 < p < 0.1). The length distribution and the alterations in morphology of the recovered fibers are described. This study is consistent with the passage of chrysotile asbestos across the gastrointestinal wall.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Accumulation of Ingested Asbestos Fibers in Rat Tissues over Time

Patel-Mandlik¹,

Millette²

1983

Environmental Health Perspectives

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show abstract

“…There have been at least 12 animal studies involving rats and baboons (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Five rat studies (4)(5)(6)(7)(8) and two baboon studies (8-10) presented evidence of asbestos penetration of the GI tract and/or migration to various tissues.…”

mentioning

confidence: 99%

“…The positive animal findings (4-10) are not completely convincing for various reasons: (a) the number of fibers observed on a grid opening basis was quite small (8, 10); (b) the qualitative presentation of data prevented numerical comparisons of test and control fiber count data (4,6); (c) too few control data were obtained (7) The negative animal studies are not completely convincing because the asbestos recovery of the sample preparation and analysis techniques were not demonstrated (11)(12)(13)(14)(15). It is possible that the methods used in these studies were not capable of detecting low levels of asbestos fibers in tissues.…”

mentioning

confidence: 99%