Analyse des Geburtengutes des Jahrgangs 1992 der Bundesrepublik Deutschland

Voigt, M.; Schneider, K. T. M.; Jährig, K

doi:10.1055/s-2007-1023283

Cited by 282 publications

(43 citation statements)

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“…adjusted birth weight percentiles derived from a German national database (13). Data management and analysis was performed using SPSS 12.0 (Chicago, IL).…”

Section: Schaefer-graf and Associatesmentioning

confidence: 99%

Maternal Lipids as Strong Determinants of Fetal Environment and Growth in Pregnancies With Gestational Diabetes Mellitus

Schaefer-Graf

K²,

Kulbacka³

et al. 2008

Diabetes Care

392

263

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OBJECTIVE -To determine the contribution of maternal glucose and lipids to intrauterine metabolic environment and fetal growth in pregnancies with gestational diabetes mellitus (GDM).RESEARCH DESIGN AND METHODS -In 150 pregnancies, serum triglycerides (TGs), cholesterol, free fatty acids (FFAs), glycerol, insulin, and glucose were determined in maternal serum and cord blood during the 3rd trimester. Maternal glucose values came from oral glucose tolerance testing and glucose profiles. Measurements of fetal abdominal circumference (AC) were performed simultaneously with maternal blood sampling and birth weight, and BMI and neonatal fat mass were obtained following delivery.RESULTS -Maternal TGs and FFAs correlated with fetal AC size (at 28 weeks: triglycerides, P ϭ 0.001; FFAs, P ϭ 0.02), and at delivery they correlated with all neonatal anthropometric measures (FFA: birth weight, P ϭ 0.002; BMI, P ϭ 0.001; fat mass, P ϭ 0.01). After adjustment for confounding variables, maternal FFAs and TGs at delivery remained the only parameters independently related to newborns large for gestational age (LGA) (P ϭ 0.008 and P ϭ 0.04, respectively). Maternal FFA levels were higher in mothers with LGA newborns than in those with appropriate for gestational age (AGA) newborns (362.8 Ϯ 101.7 vs. 252.4 Ϯ 10.1, P ϭ 0.002). Maternal levels of TGs, FFAs, and glycerol at delivery correlated with those in cord blood (P ϭ 0.003, P ϭ 0.004, and P ϭ 0.005, respectively). Fetal triglyceride and cholesterol levels were negatively correlated with newborn birth weight (P ϭ 0.001), BMI (P ϭ 0.004), and fat mass (P ϭ 0.001). TGs were significantly higher in small for gestational age (SGA) newborns compared with AGA or LGA newborns, while insulin-to-glucose ratio and FFAs were the highest in LGA newborns.CONCLUSIONS -In well-controlled GDM pregnancies, maternal lipids are strong predictors for fetal lipids and fetal growth. Infants with abnormal growth seem to be exposed to a distinct intrauterine environment compared with those with appropriate growth.

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“…adjusted birth weight percentiles derived from a German national database (13). Data management and analysis was performed using SPSS 12.0 (Chicago, IL).…”

Section: Schaefer-graf and Associatesmentioning

confidence: 99%

Maternal Lipids as Strong Determinants of Fetal Environment and Growth in Pregnancies With Gestational Diabetes Mellitus

Schaefer-Graf

K²,

Kulbacka³

et al. 2008

Diabetes Care

392

263

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“…Stillbirth is defined as intrauterine death of a child with a weight of at least 500 g. Preterm delivery is defined as delivery before 37 completed weeks of gestation. Small for gestational age (SGA) was defined as a birth weight below the 3rd percentile, according to published reference values in a German population [15]. Obesity is defined as a BMI ≥30.…”

Section: Methodsmentioning

confidence: 99%

Perinatal Mortality and Advanced Maternal Age

Mutz-Dehbalaie

Scheier

Jerabek-Klestil

et al. 2013

Gynecol Obstet Invest

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Objective: To investigate the impact of advanced maternal age on the rate of perinatal mortality. Design: Retrospective cohort study including all 56,517 singleton hospital deliveries between 1999 and 2008. Methods: Data were analyzed according to maternal age at delivery in 3 groups of women, 25-34 years, 35-39 years and ≥40 years, using the youngest as the reference group. Results: Odds ratios (ORs) for antenatal deaths were 0.98 (CI: 0.67-1.43) and 2.57 (CI: 1.57-4.22) for age groups 35-39 years and ≥40 years, respectively. Significant differences in neonatal mortality rates between the age groups were not found. Significant amendable risk factors were attendance of <4 health care visits (OR = 15.55, CI: 9.47-25.51 in age group 35-39 years; OR = 16.38, CI: 9.78-27.43 in the age group ≥40 years) and obesity (OR = 1.85, CI: 1.27-2.70 in age group 35-39 years; OR = 1.83, CI: 1.22-2.74 in the age group ≥40 years). In the multivariate regression analysis, the adjusted ORs for perinatal mortality were 1.03 (95% CI: 0.77-1.39) and 1.66 (95% CI: 1.03-2.66) for age groups 35-39 and ≥40, respectively. Conclusions: Women older than 40 years carry an increased risk for stillbirth. Important amendable risk factors are obesity and poor antenatal care.

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“…Rapid weight gain was defined as a weight gain above the 75th percentile of the whole group. The group of children who were born small for their gestational age was defined by comparing the birth weight to the reference data of Voigt et al [34] with a cutoff at the 3rd percentile (n = 103). …”

Section: Methodsmentioning

confidence: 99%

Reference Values and Early Determinants of Intra-Abdominal Fat Mass in Primary School Children

Schnurbein

Klenk²,

Galm³

et al. 2011

Horm Res Paediatr

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Background: Intra-abdominal fat (IAF) is a valuable predictor of cardiovascular morbidity. However, neither reference values nor determinants are known in children. Methods: IAF was assessed as sonographically measured intra-abdominal depth in 1,046 children [median age 7.6 years, interquartile range (IQR) 7.2–7.9; 54% boys] of the URMEL-ICE study. Results: The intraclass correlation coefficient for intraobserver agreement was 0.93. The median IAF showed a significant gender difference (boys: 54.6 mm, IQR 50.1–59.3, vs. girls: 51.7 mm, IQR 46.3–56.4; p < 0.001). Age- and gender-specific centiles were generated. IAF showed a positive correlation to systolic blood pressure [regression coefficient (β) = 0.24 mm Hg/mm; p < 0.001] and a negative correlation to HDL cholesterol (β = –0.01 mmol/l/mm; p < 0.001). IAF showed a positive association with increased paternal and maternal BMI (β = 0.28 mm/kg/m² and 0.27 mm/kg/m²; p < 0.001), increased weight gain in the first 2 years of life (β = 3.04 mm; p < 0.001), and maternal smoking during pregnancy (β = 2.4 mm; p = 0.001). Increased parental education was negatively associated with IAF (maternal: β = –0.65 mm/degree; p = 0.004, and paternal: β = –0.61 mm/degree; p = 0.002). Conclusion: Sonography was a reliable tool to estimate IAF. Factors influencing IAF included rapid infant weight gain, smoking during pregnancy, and parental BMI and education. Since IAF showed an association with cardiovascular risk factors even in prepubertal children, it might become a valuable predictor of cardiovascular vulnerability.

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Analyse des Geburtengutes des Jahrgangs 1992 der Bundesrepublik Deutschland

Cited by 282 publications

References 0 publications

Maternal Lipids as Strong Determinants of Fetal Environment and Growth in Pregnancies With Gestational Diabetes Mellitus

Maternal Lipids as Strong Determinants of Fetal Environment and Growth in Pregnancies With Gestational Diabetes Mellitus

Perinatal Mortality and Advanced Maternal Age

Reference Values and Early Determinants of Intra-Abdominal Fat Mass in Primary School Children

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