Analyse des facteurs influençant les taux cumulatifs d’accouchement en AMP sur une cohorte de 1001 couples

Pouly, Jean-Luc; Ouziel, L.; Grémeau, Anne-Sophie; Mouzon, J. de; Janny, L.; Vignancour, S.; Dejou, L.; Brugnon, Florence

doi:10.1016/j.gyobfe.2012.01.005

Cited by 9 publications

(2 citation statements)

References 14 publications

(18 reference statements)

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“…When the first step went well, there were no clear differences in early discontinuation whatever the course after this first step of the failed IVF attempt (fresh embryo transfer, frozen embryo transfers, pregnancy). The higher proportion of discontinuation among women with no or few oocytes retrieved is in agreement with two previous studies carried out in Britain and in France (Pouly et al, 2012;Sharma et al, 2002) and in contradiction with one US study (Pearson et al, 2009). In the British study (Sharma et al, 2002), retrieval of 5 oocytes was associated with a higher proportion of discontinuation (77% versus 60%, P < 0.05) whereas in the US study (Pearson et al, 2009), biochemical pregnancy and spontaneous abortion were associated with a greater probability of discontinuation.…”

Section: Categorysupporting

confidence: 87%

“…More couples with unexplained infertility discontinued IVF treatment early (31%) than couples with male factor infertility (22%). The few studies that have explored discontinuation in relation to cause of infertility also suggested an association between cause and discontinuation, but they reached contradictory conclusions on the direction of this association (Brandes et al, 2009;Pouly et al, 2012;Verberg et al, 2008). Unexplained infertility was associated with a lower proportion of discontinuation of fertility care in a study conducted in the Netherlands (Brandes et al, 2009).…”

Section: Categorymentioning

confidence: 99%

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Medical factors associated with early IVF discontinuation

Troude

Guibert

Bouyer

et al. 2014

Reproductive BioMedicine Online

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Even when IVF is reimbursed by the social insurance system, as in France, high discontinuation rates have been reported and some patients drop out as soon as the first failed IVF cycle. This study aims to investigate medical factors associated with treatment discontinuation in an IVF centre after the first unsuccessful cycle. The study included 5135 couples recruited in eight French IVF centres and who had had an unsuccessful first IVF cycle in these centres in 2000-2002 (i.e. no live birth). Of these couples with a first failed IVF, 1337 did not have a second IVF in the centre (26%, 'early discontinuation group') and 3798 continued treatment with a second IVF in the centre. The characteristics of couples who discontinued IVF treatment were compared with those who continued using logistic regressions. Older women, women with duration of infertility >5years, with female factor or unexplained infertility, with 0 or 1 oocyte retrieved and no embryo transfer during the first IVF were more likely to discontinue treatment early. Risk of early discontinuation was associated with medical factors that are also well known to be associated with impaired chance of successful IVF. Even when IVF is reimbursed by the social insurance system, as in France, high discontinuation rates have been reported and some patients drop out as soon as the first failed IVF cycle. This study aims to investigate medical factors associated with treatment discontinuation in an IVF centre after the first unsuccessful cycle. The study included 5135 couples recruited in eight French IVF centres who had had an unsuccessful first IVF cycle in these centres in 2000-2002 (i.e. who remained childless after a first cycle). Of these couples with a first failed IVF, 1337 did not have a second IVF in the centre and 3798 continued treatment with a second IVF in the centre. The characteristics of couples who discontinued IVF treatment were compared with those who continued. After a first failed IVF cycle, more than one-quarter (26%) of couples discontinued IVF treatment. Older women, women with duration of infertility >5years, with female factor or unexplained infertility, with 0 or 1 oocyte retrieved and with no embryo transfer during the first IVF were more likely to discontinue treatment early. The risk of early discontinuation was associated with medical factors that are also well known to be associated with impaired chance of success during IVF treatment. A next step would be to examine whether the early discontinuation results from a decision of the couple themselves, from medical, psychological and/or social staff counselling or from some combination of all of these factors.

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Section: Categorysupporting

confidence: 87%

Section: Categorymentioning

confidence: 99%

Medical factors associated with early IVF discontinuation

Troude

Guibert

Bouyer

et al. 2014

Reproductive BioMedicine Online

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Quand faut-il conseiller d'arrêter l'assistance médicale à la procréation classique ?

Antoine,

Selleret

2023

Infertilité

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In Vitro Fertilization in Women With Inflammatory Bowel Disease Is as Successful as in Women From the General Infertility Population

Oza

Pabby

Dodge

et al. 2015

Clinical Gastroenterology and Hepatology

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BACKGROUND & AIMS Inflammatory bowel disease (IBD) affects women of reproductive age, so there are concerns about its effects on fertility. We investigated the success of in vitro fertilization (IVF) in patients with IBD compared with the general (non-IBD) IVF population. METHODS We conducted a matched retrospective cohort study of female patients with IBD who under-went IVF from 1998 through 2011 at 2 tertiary care centers. Patients were matched 4:1 to those without IBD (controls). The primary outcome was the cumulative rate of live births after up to 6 cycles of IVF. Secondary outcomes included the proportion of patients who became pregnant and the rate of live births for each cycle. RESULTS Forty-nine patients with Crohn’s disease (CD), 71 patients with ulcerative colitis (UC), 1 patient with IBD-unclassified, and 470 controls underwent IVF during the study period. The cumulative rate of live births was 53% for controls, 69% for patients with UC (P = .08 compared with controls), and 57% for patients with CD (P = .87 compared with controls). The incidence of pregnancy after the first cycle of IVF was similar among controls (40.9%), patients with UC (49.3%; P = .18), and patients with CD (42.9%; P = .79). Similarly, the incidence of live births after the first cycle of IVF was similar among controls (30.2%), patients with UC (33.8%; P = .54), and patients with CD (30.6%; P = .95). CONCLUSIONS Based on a matched cohort study, infertile women with IBD achieve rates of live births after IVF that are comparable with those of infertile women without IBD.

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Analyse des facteurs influençant les taux cumulatifs d’accouchement en AMP sur une cohorte de 1001 couples

Cited by 9 publications

References 14 publications

Medical factors associated with early IVF discontinuation

Medical factors associated with early IVF discontinuation

Quand faut-il conseiller d'arrêter l'assistance médicale à la procréation classique ?

In Vitro Fertilization in Women With Inflammatory Bowel Disease Is as Successful as in Women From the General Infertility Population

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