Analogous cognitive strategies for tactile learning in the rodent and human brain

Banerjee, Abhishek; Wang, Bin A.; Teutsch, Jasper; Helmchen, Fritjof; Pleger, Burkhard

doi:10.1016/j.pneurobio.2023.102401

Cited by 2 publications

(1 citation statement)

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“…The present findings, therefore, suggest a path for new experiments in rodents, either by directly activating or silencing critical regions of these networks during tactile width discrimination, or by altering the characteristics of the behavioral task (for example, introducing multiple blocks of trials). In addition, the present study also suggests that networks associated with "between-subjects" and "within-subjects" processing, should have different subcortical substrates (e.g., involving limbic structures and/or thalamic nuclei) (Banerjee et al, 2023). Therefore, the findings of the present study support the notion that a systematic description of tactile width discrimination in humans can significantly improve our current knowledge on tactile processing in this species and benefit from the large body of knowledge existing in rodents (Krupa et al, 2001(Krupa et al, , 2004Wiest et al, 2010;Pais-Vieira et al, 2013a,b, 2015Thomson et al, 2014;Kunicki et al, 2019), while also contributing with new research directions.…”

Section: Comparison To Rodentsmentioning

confidence: 54%

Neurophysiological correlates of tactile width discrimination in humans

Pais-Vieira

Allahdad

Perrotta

et al. 2023

Front. Hum. Neurosci.

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IntroductionTactile information processing requires the integration of sensory, motor, and cognitive information. Width discrimination has been extensively studied in rodents, but not in humans.MethodsHere, we describe Electroencephalography (EEG) signals in humans performing a tactile width discrimination task. The first goal of this study was to describe changes in neural activity occurring during the discrimination and the response periods. The second goal was to relate specific changes in neural activity to the performance in the task.ResultsComparison of changes in power between two different periods of the task, corresponding to the discrimination of the tactile stimulus and the motor response, revealed the engagement of an asymmetrical network associated with fronto-temporo-parieto-occipital electrodes and across multiple frequency bands. Analysis of ratios of higher [Ratio 1: (0.5–20 Hz)/(0.5–45 Hz)] or lower frequencies [Ratio 2: (0.5–4.5 Hz)/(0.5–9 Hz)], during the discrimination period revealed that activity recorded from frontal-parietal electrodes was correlated to tactile width discrimination performance between-subjects, independently of task difficulty. Meanwhile, the dynamics in parieto-occipital electrodes were correlated to the changes in performance within-subjects (i.e., between the first and the second blocks) independently of task difficulty. In addition, analysis of information transfer, using Granger causality, further demonstrated that improvements in performance between blocks were characterized by an overall reduction in information transfer to the ipsilateral parietal electrode (P4) and an increase in information transfer to the contralateral parietal electrode (P3).DiscussionThe main finding of this study is that fronto-parietal electrodes encoded between-subjects’ performances while parieto-occipital electrodes encoded within-subjects’ performances, supporting the notion that tactile width discrimination processing is associated with a complex asymmetrical network involving fronto-parieto-occipital electrodes.

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Section: Comparison To Rodentsmentioning

confidence: 54%

Neurophysiological correlates of tactile width discrimination in humans

Pais-Vieira

Allahdad

Perrotta

et al. 2023

Front. Hum. Neurosci.

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FPM-WSI: Fourier ptychographic whole slide imaging via feature-domain backdiffraction

Zhang,

Wang,

et al. 2024

Optica

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Fourier ptychographic microscopy (FPM) theoretically provides a solution to the trade-off between spatial resolution and field of view (FOV), and has promising prospects in digital pathology. However, block reconstruction and then stitching has become an unavoidable procedure for reconstruction of large FOV due to vignetting artifacts. This introduces digital stitching artifacts, as the existing image-domain optimization algorithms are highly sensitive to systematic errors. Such obstacles significantly impede the advancement and practical implementation of FPM, explaining why, despite a decade of development, FPM has not gained widespread recognition in the field of biomedicine. We report a feature-domain FPM (FD-FPM) based on the structure-aware forward model to realize stitching-free, full-FOV reconstruction. The loss function is uniquely formulated in the feature domain of images, which bypasses the troublesome vignetting effect and algorithmic vulnerability via feature-domain backdiffraction. Through massive simulations and experiments, we show that FD-FPM effectively eliminates vignetting artifacts for full-FOV reconstruction, and still achieves impressive reconstructions despite the presence of various systematic errors. We also found it has great potential in recovering the data with a lower spectrum overlapping rate, and in realizing digital refocusing without a prior defocus distance. With FD-FPM, we achieved full-color and high-throughput imaging (4.7 mm diameter FOV, 336 nm resolution in the blue channel) free of blocking-and-stitching procedures on a self-developed Fourier ptychographic microscopy whole slide imaging platform. The reported FD-FPM shows the value of FPM for various experimental circumstances, and offers physical insights useful for the developments of models for other computational imaging techniques. The reported platform demonstrates high-quality, high-speed imaging and low cost, and could find applications in many fields of biomedical research, as well as in clinical applications.

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Analogous cognitive strategies for tactile learning in the rodent and human brain

Cited by 2 publications

References 152 publications

Neurophysiological correlates of tactile width discrimination in humans

Neurophysiological correlates of tactile width discrimination in humans

FPM-WSI: Fourier ptychographic whole slide imaging via feature-domain backdiffraction

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