Análogos sintéticos da cheferina I: interação com íons metálicos divalentes e o seu efeito na internalização celular e nas atividades anticandida e candidacida

Reichert, Thaís

doi:10.11606/d.46.2019.tde-27062019-103116

Cited by 1 publication

(2 citation statements)

References 111 publications

(150 reference statements)

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“…Shep I and the Shep I C-terminal amidated analogues, Shep Ia(amidated), Shep I(3-28)a, and Shep I(6-28)a, tested increased their activity up to 8-fold in the presence of 10 μM ZnCl2 [91]. In the case of Shep Ia, the increase in activity was not observed when 10 μM Ca 2+ , Mg 2+ , or Cu 2+ was present, indicating that the synergy is unique to Zn(II) [92]. Additional studies showed that a fluorescein-labeled version of Shep Ia (FAM-Shep Ia) is internalized into Candida species via a direct translocation as well as endocytosis.…”

Section: Shepherinmentioning

confidence: 99%

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The Synergy Between Zinc and Antimicrobial Peptides: An Insight into Unique Bioinorganic Interactions

Donaghy¹,

Javellana²,

Hong³

et al. 2023

Preprint

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Antimicrobial peptides (AMPs) are essential components of innate immunity across all species. AMPs have become the focus of attention in recent years as scientists are addressing antibiotic resistance, a public health crisis that has reached epidemic proportions. This family of peptides are a promising alternative to current antibiotics due to their broad-spectrum antimicrobial activity and tendency to avoid resistance development. A subfamily of AMPs interact with metal ions to potentiate their antimicrobial effectiveness, as such they have been termed metalloAMPs. In this work, we review the scientific literature of metalloAMPs that enhance their antimicrobial efficacy when combined with the essential metal ion, zinc (II). Beyond the role played by Zn(II) as a cofactor in different systems, it is well-known that this metal ion plays an important role in innate immunity. Here, we classify the different types of synergistic interactions between AMPs and Zn(II) into three distinct classes. By better understanding how each class of metalloAMPs uses Zn(II) to potentiate their activity, researchers can begin to exploit these interactions in the development of new antimicrobial agents and accelerate their use as therapeutics.

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Section: Shepherinmentioning

confidence: 99%

“…Shep I and some of its derivatives showed synergistic activity with Zn(II) against a variety of Candida species [91,92]. Shep I and the Shep I C-terminal amidated analogues, Shep Ia(amidated), Shep I(3-28)a, and Shep I(6-28)a, tested increased their activity up to 8-fold in the presence of 10 μM ZnCl2 [91].…”

Section: Shepherinmentioning

confidence: 99%