DOI: 10.11606/d.46.2019.tde-27062019-103116
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Análogos sintéticos da cheferina I: interação com íons metálicos divalentes e o seu efeito na internalização celular e nas atividades anticandida e candidacida

Abstract: À minha família pelo carinho e torcida, em especial à minha mãe Magaly, ao meu pai Curt e irmão Henrique Reichert pela tolerância, paciência e apoio que me possibilitaram chegar aqui. Ao meu namorado Guilherme H. P. da Silva por seu amor e carinho e pela constante ajuda, incentivo e suporte. À Profa. Dra. Maria Terêsa Machini pela oportunidade do Mestrado, pelos ensinamentos, desafios e principalmente pela amizade, paciência, apoio e compreensão nos momentos mais difíceis. Ao Prof. Dr. Breno P. Espósito pela o… Show more

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Cited by 2 publications
(4 citation statements)
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References 111 publications
(150 reference statements)
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“…Shep I and the Shep I C-terminal amidated analogues, Shep Ia(amidated), Shep I(3-28)a, and Shep I(6-28)a, tested increased their activity up to 8-fold in the presence of 10 µM ZnCl 2 [90]. In the case of Shep Ia, the increase in activity was not observed when 10 µM Ca 2+ , Mg 2+ , or Cu 2+ was present, indicating that the synergy is unique to Zn(II) [91]. Additional studies showed that a fluorescein-labeled version of Shep Ia (FAM-Shep Ia) is internalized into Candida species via a direct translocation as well as endocytosis.…”
Section: Shepherinmentioning
confidence: 99%
See 1 more Smart Citation
“…Shep I and the Shep I C-terminal amidated analogues, Shep Ia(amidated), Shep I(3-28)a, and Shep I(6-28)a, tested increased their activity up to 8-fold in the presence of 10 µM ZnCl 2 [90]. In the case of Shep Ia, the increase in activity was not observed when 10 µM Ca 2+ , Mg 2+ , or Cu 2+ was present, indicating that the synergy is unique to Zn(II) [91]. Additional studies showed that a fluorescein-labeled version of Shep Ia (FAM-Shep Ia) is internalized into Candida species via a direct translocation as well as endocytosis.…”
Section: Shepherinmentioning
confidence: 99%
“…Shep I and some of its derivatives showed synergistic activity with Zn(II) against a variety of Candida species [90,91]. Shep I and the Shep I C-terminal amidated analogues, Shep Ia(amidated), Shep I(3-28)a, and Shep I(6-28)a, tested increased their activity up to 8-fold in the presence of 10 µM ZnCl 2 [90].…”
Section: Shepherinmentioning
confidence: 99%
“…Shep I and the Shep I C-terminal amidated analogues, Shep Ia(amidated), Shep I(3-28)a, and Shep I(6-28)a, tested increased their activity up to 8-fold in the presence of 10 μM ZnCl2 [91]. In the case of Shep Ia, the increase in activity was not observed when 10 μM Ca 2+ , Mg 2+ , or Cu 2+ was present, indicating that the synergy is unique to Zn(II) [92]. Additional studies showed that a fluorescein-labeled version of Shep Ia (FAM-Shep Ia) is internalized into Candida species via a direct translocation as well as endocytosis.…”
Section: Shepherinmentioning
confidence: 99%
“…Shep I and some of its derivatives showed synergistic activity with Zn(II) against a variety of Candida species [91,92]. Shep I and the Shep I C-terminal amidated analogues, Shep Ia(amidated), Shep I(3-28)a, and Shep I(6-28)a, tested increased their activity up to 8-fold in the presence of 10 μM ZnCl2 [91].…”
Section: Shepherinmentioning
confidence: 99%