Análogos de la GnRH en el tratamiento de los miomas

Murillo, Ester Ortiz; Cano, Antonio

doi:10.1016/s0025-7753(13)70051-4

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…Therefore, these compounds helped to restore haemoglobin levels and reduce blood loss during surgery. Their main disadvantage was rebound growth of fibroids upon cessation of therapy, along with the side effects associated with hypoestrogenism, such as climacteric symptoms and loss of bone mass [ 8 ]. Selective oestrogen receptor modulators (SERMs), such as raloxifene, were shown to induce fibroid regression only in postmenopausal women, but the therapy had major side effects.…”

Section: Introductionmentioning

confidence: 99%

The role of levonorgestrel intrauterine systems in the treatment of symptomatic fibroids

Wrona

Stępniak

Czuczwar

2017

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Uterine fibroids are considered to be the most frequently occurring tumours in females. The majority of fibroids do not require any treatment. When symptomatic, the major ailments include abnormal uterine bleeding, painful menstruation, pelvic pressure or pain, urinary problems, constipation, infertility, and recurrent pregnancy loss. Surgery remains a mainstay of symptomatic uterine fibroids therapy; however, minimally-invasive techniques and pharmacological management have become more available. The levonorgestrel intrauterine system (LNG-IUS) is a T-shaped device with a vertical stem containing a reservoir of levonorgestrel and is widely known for its contraception effect. Moreover, the non-contraceptive benefits of the LNG-IUS have been previously confirmed by numerous studies. LNG-IUS causes reduction of the duration and the amount of menstrual bleeding, with minimal side effects due to release of hormones at the targeted organ. Currently, results from systematic reviews show that LNG-IUS may be an effective and safe treatment for symptomatic uterine fibroids in premenopausal women. However, further studies are required to consolidate the usage of LNG-IUS in the treatment of symptomatic uterine fibroids.

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Section: Introductionmentioning

confidence: 99%

The role of levonorgestrel intrauterine systems in the treatment of symptomatic fibroids

Wrona

Stępniak

Czuczwar

2017

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“…En cuanto a los anticonceptivos orales aplicados con antiinflamatorios no esteroideos y progestanos no ha presentado una efectividad contundente frente la presencia de fibromas. 57 Entre estos anticonceptivos se tiene el acetato de medroxiprogesterona de depósito (AMPD, hormona de tipo sintética aplicada intramuscularmente dirigida a reducir el tamaño del fibroma, la levonorgestrel dispositivo intrauterino que actúa liberando progesterona originando la supresión del endometrio por lo tanto reduce el sangrado mestrual. 58 Acetato de Ulipristal.-Son moduladores selectivos de los receptores de progesterona (SPRM), como el acetato de ulipristal, empleados en los tratamientos de miomas con sintomatología de moderada a severa es una buena alternativa no quirúrgica, hallándose contraindicado en pacientes con trastorno hepático, 59 consiste en la toma oral de Analítico debido a que se evaluó la asociación de los factores reproductivos y endocrinos con el desarrollo de fibroma uterino.…”

Section: Antiinflamatorios (Aines)unclassified

“…Factor asociado a los estrógenos y progesterona que influyen, alterando el funcionamiento normal del miometrio del ovario. [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] Perdida espontanea del producto…”

Section: Factores Endocrinosunclassified

Factores reproductivos y endocrinos asociados a fibromas uterinos en pacientes atendidos en el Hospital Augusto Hernández Mendoza de Ica, 2021 - 2022

Huamani Reyes

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Titulo: Factores reproductivos y endocrinos asociados a fibromas uterinos en pacientes atendidos en el Hospital Augusto Hernández Mendoza de Ica, 2021 – 2022. Objetivo: Determinar la asociación de los factores reproductivos y endocrinos asociados a fibromas uterinos en pacientes atendidos en el Hospital Augusto Hernández Mendoza de Ica, 2021 – 2022. Material y Métodos: Estudio no experimental de alcance relacional, transversal y retrospectivo, con diseño de casos y controles, se obtuvo 56 casos y 112 controles (relación 1:2) mediante muestreo probabilístico simple, los datos se registraron en una de ficha de recolección. Resultados: Los de mayor porcentaje en las características de la población de estudio se tiene que la edad está en etapa fértil (20 a 39 años) con 54.8%, educación superior de 48.8%, estado civil casada con 34.5% y divorciada (32.1%), de ocupación independiente (51,2%). Los datos de los factores en los casos se tiene que 71.43% son nulíparas,16.02% uníparas y 12.5% multíparas, la edad reproductiva es un 67.90%, en cuanto al aborto el 35.7% la presentó, la menarquia temprana fue de 33.9% y el 71,4% empleó anticonceptivos hormonales. En cuanto asociaciones significativas la paridad mostro un p< 0.001) con un OR= 15, IC95=[6.842-32.886],con el aborto (p=0,002) y un OR=2.888 IC95= [1.484 -5-623], con la menarquia temprana (p=0,000) y OR= 2.46 , IC95=[1.05-4.89] y no mostraron asociación con el fibroma uterino, la edad reproductiva (p=1.148) y el uso de anticonceptivos hormonales (p=0.057) Conclusiones: Al utilizar la regresión logística binaria para detectar falsa asociaciones se concluyó que los factores endocrinos y reproductivos asociados a fibroma uterino son la paridad y la menarquia temprana en las pacientes atendidas en el hospital Augusto Hernández Mendoza de Ica, 2021-2022.

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Gonadorelins adherence in prostate cancer: A time‐series analysis of England’s national prescriptions during the COVID‐19 pandemic (from Jan 2019 to Oct 2020)

Barrett

Barrett²,

Dhar

et al. 2021

BJUI Compass

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Objective To examine the effect of the COVID‐19 pandemic on gonadorelin analogue prescription for community patients in England. Materials and methods We included data from all primary‐care patients who had relevant prescriptions dispensed in the community in England. Descriptive statistics and interrupted time series analysis over 22 months (15 months before and 7 months after lockdown) was evaluated. Results A total of 22 months’ worth of data were analyzed (or 1 041 638 total items, monthly average 47 347 items). Goserelin; leuprorelin, and triptorelin are the medicines most used by total quantity in the study period. Simple descriptive statistics show that mean values have declined during the pandemic. The Interrupted Time Series (ARIMA Modeling) shows declining trends. After the pandemic's onset, we observe a statistically significant downward trend for goserelin ( P = .017) and leuprorelin ( P = .014). As these are the major constituents of the model, we interpret this overall data as showing a significant downward category trend. Aside from linearity, a significant step change was noted for leuprorelin ( P = .029) showing an increase in prescription items with a similar effect that is close to being statistically significant for goserelin ( P = .051). The actual cost of medicines shows minimal variation suggesting that prices of individual medicines have remained stable. The regional data showed variation but this was not statistically significant. In all cases, the Oct‐20 figures are lower “year on year.” This novel work reports the impact of a global pandemic on prescription volumes of prostate cancer (PCa) medicines. Conclusions A worrying decrease in prescription medicines raises concerns for the care of PCa patients. We encourage diagnosed patients to discuss their planned care with their doctor.

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Análogos de la GnRH en el tratamiento de los miomas

Cited by 3 publications

References 28 publications

The role of levonorgestrel intrauterine systems in the treatment of symptomatic fibroids

The role of levonorgestrel intrauterine systems in the treatment of symptomatic fibroids

Factores reproductivos y endocrinos asociados a fibromas uterinos en pacientes atendidos en el Hospital Augusto Hernández Mendoza de Ica, 2021 - 2022

Gonadorelins adherence in prostate cancer: A time‐series analysis of England’s national prescriptions during the COVID‐19 pandemic (from Jan 2019 to Oct 2020)

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