This paper presents a comprehensive review of the problematic issue of embryonic mortality in cattle and develops possible strategies towards a hormonal antiluteolitic." recent and extensive investigation using eCG is also described.The paper evaluates the effect of the application of IU of equine Chorionic Gonadotrophin eCG on day or of a synchronization protocol for embryo transfer upon follicular development day , luteal development day , progesterone concentration P and and percentage of pregnancy day in Holstein heifers. The relationships between dominant follicle diameter DFD day and the luteal volume VL day , as well as the concentration of P day are analysed without eCG treatments the DFD day , VL day and concentration of P day versus percentage of pregnancy day are then analysed with the treatment.There was no effect P> . of the day of eCG administration or on the number of dominant follicles, but P < . for diameter. The day of eCG administration or had no effect P> . on the number of corpora lutea, VL, P concentration and or pregnancy day . There was no relationship P> . between the DFD day and VL, but P < . between the VL and P levels day . In analysing the relationship between treatments eCG day or , the DFD day , VL day and the concentration of P day versus percentage of pregnancy day , we observed that the only positive correlation P < . existed between this variable and the concentration of P . It has been suggested that during pregnancy establishment there is a well defined critical period from day to day [ ] we can suppose that reproductive biology during this period would be multifactorial and complex, where the endometrium receives a non-suitable antiluteolytic signal, of course without blocking prostaglandin F PGF endometrial production, triggering the lysis of the corpus luteum CL maintaining pregnancy depends upon CL functionality [ ]. "t that point, antiluteolytic signal is generated by the embryo into mononuclear trophoblast cells, which secrete interferon tau IFN-τ , thereby blocking PGF synthesis produced at endometrial level [ ]. The latter process suggests that embryo loss could occur because of a weak or inadequate signal due to an asynchrony between a decreasing progesterone P and the degree of embryo development, so it does not inhibit the synthesis of uterine PGF [ ].The critical nature of the period of recognition, apposition and adhesion of the embryo to uterine endometrium during implantation demands strict synchronization between the transferred embryo and the recipient, emphasizing the importance of both the uterine environment and the embryo signals generating MRP [ ] [ ]. These signals must be released at the time and concentration required to guarantee CL structure and function maintenance, generating continuous P production for embryotrophic environment maintenance to support the normal development of the conceptus the embryo including all the linked layers [ ].In relation to the influence of P on certain events related to pregnancy maintenance from early stages ...