Analisis <i>In Silico</i> Senyawa Aktif Batang Kayu Bajakah (<i>Spatholobus littoralis</i> Hassk) Sebagai Terapi Psoriasis

Abstract

Background : Innovative topical psoriasis therapy continues to be developed, Spatholobus littoralis Hassk or Bajakah has antipsoriatic activity so can be used as a topical herbal medicine in reducing the severity of psoriasis. In silico is a computational experiment which is analogous to biological experiments in vivo and in vitro. Objective : To evaluate content of Spatholobus littoralis Hassk using in silico analysis in the treatment of psoriasis. Methods : The active compound Spatholobus littoralis Hassk extracted from the knapsack database. The simplified molecular input line entry system (SMILE) format was taken from the pubchem database. Prediction in antioxidants, antiinflammatory, antipruritic and immunosuppressive was done using a pass server. The molecular mechanism of active compounds in human body was taken from search tool for interacting chemicals (STITCH) which was predicted experimentally, then analyzed computationally. Further pathway analysis using cytoscape software. Results : There are 14 active compounds in Spatholobus littoralis Hassk have potential as antioxidants, anti-inflammatory, antipruritic and immunosuppressive are predicted to have ability test computationally tested activity but laboratory tests have not been proven or have little potential. The highest bioactivity potential of Spatholobus littoralis Hassk is antioxidants where the most important role is dihydrokaemferol with an average probable to be active (Pa) value of 0.691, the compound has ability to computationally test but in laboratory tests it has not been proven or has a small potential. Conclusions : Spatholobus littoralis Hassk is a good choice for the treatment of psoriasis. Latar belakang : Terapi psoriasis topikal inovatif terus dikembangkangkan, Spatholobus littoralis Hassk atau bajakah memiliki aktivitas antipsoriatik sehingga dapat digunakan sebagai obat herbal topikal dalam mengurangi keparahan psoriasis. In silico merupakan percobaan komputasi yang analog dengan percobaan biologis secara in vivo dan in vitro. Tujuan : Untuk mengevaluasi kandungan Spatholobus littoralis Hassk menggunakan analisis in silico pada pengobatan psoriasis. Metode : Senyawa aktif Spatholobus littoralis Hassk yang diekstraksi dari database knapsack. Format simplified molecular input line entry system (SMILE) diambil dari basis data pubchem. Prediksi dalam antioksidan, antiinflamasi, antipruritus dan immunosupresor dilakukan menggunakan pass server. Mekanisme molekuler senyawa aktif dalam tubuh manusia diambil dari search tool for interacting chemicals (STITCH) yang diprediksi secara eksperimental, kemudian dianalisis secara komputasional. Analisis pathway lebih lanjut menggunakan perangkat lunak cytoscape. Hasil : Terdapat 14 senyawa aktif pada Spatholobus littoralis Hassk yang memilik potensi sebagai antioksidan, antiinflamasi, antipruritus dan immunosupresor diprediksi memiliki kemampuan pada aktivitas yang diuji secara komputasional, namun secara uji laboratorium belum terbukti atau memiliki potensi kecil. Potensi bioaktivitas Spatholobus littoralis Hassk tertinggi adalah antioksidan dimana yang paling berperan adalah dihydrokaemferol dengan ata-rata nilai probable to be active (Pa) 0,691 dimana senyawa tersebut secara komputasional memiliki kemampuan pada aktivitas yang diuji namun secara uji laboratorium belum terbukti atau memiliki potensi kecil. Kesimpulan : Spatholobus littoralis Hassk merupakan pilihan yang baik untuk terapi psoriasis karena memiliki efek antioksidan, antiinflamasi, antipruritus dan immunosupresor serta menguntungkan dari segi ketersediaan serta keamanan.

Variability and pharmacological potential of bajakah (Spatholobus sp.) as an indigenous medicinal plant: a review

“…as a psoriasis therapy. This shows the potential of bajakah as an effective traditional medicine for the treatment of skin diseases [38]. Based on the results of this in silico analysis, the study concluded that bajakah wood (Spatholobus littoralis Hassk.)…”

“…Although there are limitations to thorough scientific research on bajakah, some early research points to the potential of this plant in traditional medicine. One study showed that bajakah was also found to have potential as a topical herbal remedy that can reduce the severity of psoriasis, a skin condition characterized by red, itchy, and scaly skin [24]. Bajakah extract has shown anti-inflammatory activity and inhibited the excessive proliferation of skin cells in psoriasis.…”

“…Overall, in silico studies have provided valuable insight into the potency of bajakah in traditional medicine. By using various tools and computing servers, this study has identified active compounds that have potential as therapeutic agents in the treatment of breast cancer and psoriasis therapy [38]. Although these findings are promising, it is important to carry out further research in the laboratory to validate the effects and safety of using bajakah in this treatment.…”

Antioxidant activity of roots, stems, and leaves Spatholobus littoralis Hassk.: an experimental study

“…These results are in accordance with research that has been done before. 17 Triterpenoids which are known to have a role as high antioxidant active compounds are aligned with research on Spatholobus littoralis Hassk. stem extract is proven to accelerate fibroblast migration and as an anti-inflammatory agent in the wound healing process.…”