Analisis Faktor Koagulasi : Korelasi Fibrinogen dengan Rendahnya Derajat Oksigenasi Pada Pasien COVID-19

Listyoko, Aditya Sri; Djajalaksana, Susanthy; Sugiri, Yani Jane

doi:10.36408/mhjcm.v8i2.549

Cited by 4 publications

(4 citation statements)

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“…(7)(8)(9) Parameter laboratorium lain yang terkait dengan koagulasi seperti fibrinogen dan D-Dimer juga diketahui terkait dengan peningkatan kejadian mortalitas. (6,10) Feritin yang diketahui terkait dengan badai sitokin yang terjadi pada COVID-19, juga dibuktikan meningkat pada pasien COVID-19 dengan prognosis buruk. (11) Hubungan parameter laboratorium dengan waktu kematian dan komorbiditas belum banyak diteliti.…”

Section: Pendahuluanunclassified

The Differences in INR and D-dimer on Mortality of COVID-19 Patients at RSUD Dr. Saiful Anwar Malang

Asyari,

Choizin,

Rakhma

2024

JK-RISK

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juta kasus kematian di seluruh dunia. Hubungan parameter laboratorium dengan waktu kematian dan komorbiditas belum banyak diteliti. Tujuan: Studi ini untuk mengetahui perbedaan INR dan D-dimer terhadap mortalitas pasien COVID-19 di RSUD Dr Saiful Anwar Malang. Metode: Studi kohort retrospektif dilakukan pada April 2020-September 2021, total 229 subjek COVID-19 terdiagnosis swab PCR. Analisis data berupa waktu kematian sejak masuk rumah sakit terbagi menjadi ≤7 hari dan >7 hari, data laboratorium, data komorbiditas dan tanpa komorbiditas. Hasil: Pada subjek tanpa komorbiditas, kadar D-Dimer signifikan lebih tinggi pada subjek dengan waktu kematian >7 hari dibanding <7 hari. Pada subjek dengan waktu kematian <7 hari, kadar PT dan INR signifikan lebih tinggi pada subjek dengan komorbiditas dibanding tanpa komorbiditas. Pada subjek dengan waktu kematian >7 hari, kadar D-Dimer dan feritin signifikan lebih rendah pada subjek dengan komorbiditas dibanding tanpa komorbiditas. Secara keseluruhan, kadar INR ditemukan signifikan lebih tinggi pada subjek dengan komorbiditas dibanding subjek tanpa komorbiditas (p<0.05). Kesimpulan: Secara keseluruhan ditemukan bahwa kadar INR signifikan lebih tinggi pada subjek dengan komorbiditas dibanding tanpa komorbiditas, serta Ddimer pada subjek dengan waktu kematian >7 hari tanpa komorbiditas signifikan lebih tinggi dibanding kelompok subjek lain.

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Section: Pendahuluanunclassified

The Differences in INR and D-dimer on Mortality of COVID-19 Patients at RSUD Dr. Saiful Anwar Malang

Asyari,

Choizin,

Rakhma

2024

JK-RISK

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“…In moderate, severe, and critical COVID-19 patients, administering LMWH or UFH anticoagulants is highly recommended, both useful as prophylaxis and in treating macrothrombi [33]. Apart from that, anticoagulants can also be given to COVID-19 patients with mild symptoms after evaluating the patient's D-Dimer levels [34]. The data from the data collection process will be displayed in descriptive tables and analyzed using the SPSS application with the Chi-Square correlation method or Fisher test on computer software.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of D-Dimer Levels in Patients Confirmed Positive for COVID-19 Aged 45 – 70 Years at UKI Hospital for the Period December 2020 – September 2021

Luhulima,

Saluntondok,

Irwan

2024

JOCAMR

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COVID-19 is a disease caused by the SARS-CoV-2 virus. COVID-19 is divided into several clinical symptoms based on a person's experiences. In severe clinical signs of COVID-19, D –Dimer will be significantly higher. This study aims to determine D-Dimer levels in COVID-19 patients aged 45 – 70 and uses a descriptive-analytic method with a retrospective cross-sectional design. The number of samples was 198 patients whose D-Dimer levels were checked and 127 patients who received anticoagulant prophylaxis. The research samples were all medical records of patients suffering from COVID-19 aged 45 - 70 years and who had checked D-Dimer levels at RSU UKI from December 2020 to September 2021 found that 145 patients (73.2%) had normal D-Dimer levels, 53 patients (26.8%) had increased D-Dimer levels. The distribution of women were 100 patients (50.5%), and men were 98 patients (49.5%), the highest range was aged 54 - 62 years with 74 patients (37.4%), clinical symptoms were being experienced by 122 patients (61.6%), and comorbid hypertension was the most common disease with 64 patients (32.3%). A significant relationship was found between D-Dimer levels and comorbidities (p=0.04). Anticoagulant prophylaxis was given to 127 patients, with mild symptoms experienced by five patients (3.6%), moderate symptoms experienced by 73 patients (57.5%), and severe symptoms experienced by 49 patients (38.6%). However, no significant relationship was found (p=0.66) between administering anticoagulant prophylaxis and D-Dimer levels in patients with mild, moderate, or severe symptoms.

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“…), and activated prothrombin thromboplastin (APTT) is known related with degrees severity, as well as a better prognosis bad (Barale & Russo, 2020) (Lippi et al, 2020) (Long et al, 2020). Other related laboratory parameters with coagulation, such as fibrinogen and D-Dimer, are known to be related to enhancement incident mortality (Simadibrata DM, 2020) (Listyoko et al, 2021) (Yorike et al, 2022). Known ferritin related to storm cytokines that occur during COVID-19, has proven to increase in COVID-19 patients with poor prognosis (Monica & Wulanjani, 2022).…”

Section: Introductionmentioning

confidence: 99%

Analysis Difference between INR and D-dimer against Mortality COVID-19 patients

Herda Asyari,

Noor Chozin,

Rakhma

2023

ihj

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As of July 2022, COVID-19 has infected 565 million people, with 6.3 million deaths worldwide. The relationship between laboratory parameters with time to death and comorbidities has not been widely studied. This study determines the difference between INR and D-dimer on the mortality of COVID-19 patients at Dr. Hospitals. In a retrospective cohort study conducted in April 2020 - September 2021, 229 COVID-19 subjects were diagnosed with swab PCR. Data analysis included time to death from hospital admission divided into <7 days and >7 days, laboratory data, comorbidity data, and no comorbidity. Data were tested using Chi-Square for categorical data, Mann-Whitney, and Kruskall Wallis for numerical data. Overall, INR levels were significantly higher in subjects with comorbidities compared to those without (p<0.05). This was based on the time to death of subjects <7 days without comorbidities. In addition, the change from hypercoagulation to hyperfibrinolysis due to excessive coagulant consumption factors, resulting in increased PT and INR in severe COVID-19 conditions. Overall, it was found that INR levels were significantly higher in subjects with comorbidities compared to subjects without comorbidities, as well as D-dimer in subjects with a time of death >7 days without comorbidities was significantly higher compared to other subject groups.

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Analisis Faktor Koagulasi : Korelasi Fibrinogen dengan Rendahnya Derajat Oksigenasi Pada Pasien COVID-19

Cited by 4 publications

References 0 publications

The Differences in INR and D-dimer on Mortality of COVID-19 Patients at RSUD Dr. Saiful Anwar Malang

The Differences in INR and D-dimer on Mortality of COVID-19 Patients at RSUD Dr. Saiful Anwar Malang

Characteristics of D-Dimer Levels in Patients Confirmed Positive for COVID-19 Aged 45 – 70 Years at UKI Hospital for the Period December 2020 – September 2021

Analysis Difference between INR and D-dimer against Mortality COVID-19 patients

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