The pandemic afflicting the world is accompanied by a social, economic, political, cultural, and climatic multi-crisis. It is the crisis of the Anthropocene Era and modern paradigms. Modern society is in a complex situation. The responses to the multicrisis, including the pandemic, will probably come from the revalorization and resignification of experiences and socioecological knowledge of communities. Their historical experiences, currently fragmented by modernization processes, will be able to intercommunicate and, with resilient energy, open new possibilities for human and planetary life. It will be a great transformation, in which old and new models of development will be in tension. These tensions will also be expressed in the form of social and political radicalization and result in conflicts over natural resources, especially water, natural forests, ecosystems, and productive land. Human and planetary life is seriously threatened. Intellectual and scientific activity must connect with the ecological knowledge of local communities to defend human and natural life.