Throughout history the issue of relations between Mexico and the United States has always been important. The relations of the countries from the interactions of borders have gained relevance with globalization. This study analyzes the United States-Mexico border from the perspective of the flow of people, transportation, trade, and investment. The methodology is quantitative, using the analysis of data from the Department of Transportation (United States), the National Institute of Geography and Statistics (Mexico) and the Ministry of Foreign Affairs (Mexico); It is also qualitative, since it uses documentary information, especially scientific articles and books. The results show that the flows have intensified with economic integration and that, despite the ups and downs in cooperation and other obstacles, they continue. The work is pertinent given the current situation of government transition in the United States and review of central issues on the bilateral agenda, exploring the flows in an integrated manner. It is concluded that it is necessary to overcome such situations in order to achieve the goals that each government and participating agents have set. Progress in the bilateral agenda implies a willingness to cooperate from both governments and participants.