Análisis de minimización de costes de darbepoetina alfa frente a epoetina alfa en pacientes con insuficiencia renal crónica sometidos a hemodiálisis

The present article discusses the importance of clinical management in the transformation of organizations and its role in the daily activities of health professionals and, in particular, of hospital pharmacists. Because of social changes, healthcare models must make the shift from more rigid management models toward new organizational models based on clinical management. From this perspective, pharmacoeconomics is viewed as a useful tool to introduce the criteria of efficiency in all decisions subject to clinical management, including those on pharmacotherapeutics. Subsequently, the application of this discipline is discussed in real decision-making scenarios and settings for its use within the context of the work of hospital pharmacy are proposed.

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Cost-effectiveness of methoxy polyethylene glycol-epoetin β versus conventional epoetin in the treatment of anaemia secondary to chronic kidney disease in clinical practice

Lorente-Fernández

Monte-Boquet

Gil-Gómez

et al. 2014

Eur J Hosp Pharm

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Objectives To assess the cost-effectiveness of methoxy polyethylene glycol-epoetin β (CERA) used in routine clinical practice for maintenance of Hb levels in patients with chronic kidney disease in predialysis and previous stabilised treatment with conventional epoetin. As secondary objective, we analyse the use of CERA in clinical practice. Methods Retrospective observational study including all patients receiving conventional epoetin who were switched to CERA over a period of 2 years. Demographic, clinical and therapeutic variables were collected. The main effectiveness outcome chosen was the difference between the haemoglobin level with conventional epoetin versus CERA after 24 weeks of treatment. Economic analysis was performed taking into account only the direct drug acquisition cost, the main cost outcome was the difference of patient/month cost with conventional epoetin versus CERA. Results Sixty-nine patients with a mean age of 68 years (35% male) were enrolled in the study. In 92.8% of cases, the starting dose used was lower than that recommended in the summary of product characteristics. Mean haemoglobin at 0 and 24 weeks was 11.9 and 11.7 g/dL, with no statistically significant difference (−0.2, 95% CI −0.6 to 0.1). With CERA, a lower proportion of patients exceeded the haemoglobin limit of 13 g/dL. The patient/month cost was 159.6€ and 169.9€ at weeks 0 and 24, with a difference of 10.3€ (95% CI −6.8 to 27.5). Conclusions CERA was as effective as conventional epoetin for the maintenance of haemoglobin levels after 24 weeks of follow-up. Conversion to CERA has led to an increase of 10.3€ the patient/month cost.

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Análisis de minimización de costes de darbepoetina alfa frente a epoetina alfa en pacientes con insuficiencia renal crónica sometidos a hemodiálisis

Abstract: In our study, we found that r-HuEpo and NESP were similarly effective in patients with CRF on haemodialysis, but that there was a significant cost increase associated with NESP treatment.

Cited by 4 publications

References 12 publications

Eficiencia de la administración mensual subcutánea de metoxi-polietilenglicol epoetina β (Mircera®) en pacientes estables en hemodiálisis previamente tratados con eritropoyetinaEficiencia de la administración sc mensual de MIRCERA en pacientes en HD

Eficiencia de la administración mensual subcutánea de metoxi-polietilenglicol epoetina β (Mircera®) en pacientes estables en hemodiálisis previamente tratados con eritropoyetinaEficiencia de la administración sc mensual de MIRCERA en pacientes en HD

Aplicación de la farmacoeconomía en la gestión clínica

Cost-effectiveness of methoxy polyethylene glycol-epoetin β versus conventional epoetin in the treatment of anaemia secondary to chronic kidney disease in clinical practice

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