Análise morfológica renal de ratas prenhes submetidas ao estresse

Custodio, M.

doi:10.11606/d.5.2006.tde-11122006-102216

Cited by 1 publication

(1 citation statement)

References 102 publications

(63 reference statements)

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“…This is also likely true for genetic determinants of spleen iron for which A/J shows high levels, although distinct gene(s) on chromosome 9 and possibly chromosome X yield singular high spleen iron contents on the C57BL/6 background. Two independent QTL approaches also identified a locus on chromosome 9 associated with high splenic iron content and also found that spleen and liver iron content were controlled independently [6,16]. Independent genetic control of tissue iron is also shown by our data as B6.A9 had high spleen iron but low liver iron content (Figure 3).…”

Section: Discussionsupporting

confidence: 78%

Mapping genes responsible for strain-specific iron phenotypes in murine chromosome substitution strains

Ajioka

LeBoeuf

Gillespie

et al. 2007

Blood Cells, Molecules, and Diseases

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The highly variable clinical phenotype observed in patients homozygous for the C282Y mutation of the hereditary hemochromatosis gene (HFE) is likely due to the influence of non-HFE modifier genes. The primary functional abnormality causing iron overload in hemochromatosis is hyper-absorption of dietary iron. We found that iron absorption in inbred mice varies in a strain-specific manner, as does the pattern of iron distribution to the liver and spleen. A/J mice absorbed approximately twice the amount of 59Fe delivered by gavage compared to the C57BL/6 strain. Genetic comparisons between A/J and C57BL/6 were facilitated by the availability of consomic chromosome substitution strains (CSS). Each CSS has an individual chromosome pair from A/J on an otherwise C57BL/6J background. We found that iron absorption and iron content in liver and in spleen were continuous variables suggesting that each trait is under multigenic control. No trait co-segregated among the CSS. Chromosome 5 from A/J, however, imparted the highest iron absorption phenotype and multiple CSS had absorption levels equivalent to A/J. Chromosomes 9 and X were associated with high spleen iron content. These data suggest that multiple genes contribute to the regulation of iron absorption and that individual organ iron phenotypes are independently regulated.

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Section: Discussionsupporting

confidence: 78%