Análise de variáveis fisiológicas de adolescentes com diagnóstico clínico de asma leve intermitente ou leve persistente quando submetidos a hipóxia aguda e teste de esforço máximo

Maldonado, Martín; Portela, Luiz Osório Cruz

doi:10.1590/s1806-37132011000600003

Cited by 4 publications

(3 citation statements)

References 17 publications

(17 reference statements)

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“…Studies have shown similar kinds of results with vilazodone and escitalopram in the context of improvement of depressive symptoms. 13,19 In a network meta-analysis, escitalopram emerged as the most efficacious agent among the SSRIs and was the best tolerated of all the antidepressants that were analyzed. 20 Similarly, vilazodone has also been shown to decrease HAM-D score in patients with MDD.…”

Section: Discussionmentioning

confidence: 99%

“…Its unique SPARI mechanism of action could also be efficacious for patients who do not respond to SSRI/SNRI monotherapy. 13 In a 12-week comparative prospective open-label randomized controlled study conducted in north India comparing the efficacy and safety of escitalopram and vilazodone in MDD, vilazodone has been found to have better efficacy, lesser weight gain, and lesser sexual dysfunction. 14 Kudyar P et al reported that escitalopram was more efficacious and better tolerated than vilazodone in patients with MDD.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness and side-effect profile of Vilazodone and Escitalopram in major Depressive Disorder – An observational study

Lella¹,

Kodali²,

Bodepudi³

et al. 2021

IJN

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Background : Major depressive disorder (MDD) is characterized by a cluster of emotional, behavioral, and cognitive features causing functional impairment. Escitalopram and Vilazodone are approved drugs in management of MDD. Escitalopram is found to be efficacious in patients with MDD. However, sexual dysfunction and weight gain are of a primary concern leading to discontinuation of treatment. Vilazodone is efficacious for patients who do not respond to SSRI/SNRI monotherapy. Evidence suggests it to be associated with a better side effect profile. Aim : To study the effectiveness and side effect profile of vilazodone and escitalopram in patients diagnosed with MDD. Materials and Methods : All patients diagnosed with MDD and commenced for the first time on vilazodone or escitalopram were included in the study via purposive sampling. Effectiveness and side effect profiles of the patients were studied by applying HAM-D and ASEC, respectively, at baseline, at weeks 1, 2, 4, 6, and 8. Results : There was a statistically significant difference in weeks 2, 4, and 6 for both the drugs. On intergroup comparison, no significant difference was found in terms of response rates. The number of side-effects was more in the escitalopram group. Conclusion : Taken together with our results, vilazodone appears to be equally effective as escitalopram in treating patients of MDD. However, vilazodone has the advantage of better tolerability as compared to escitalopram. Key messages: Vilazodone was found to be equally effective as escitalopram in patients with MDD and has the advantage of better tolerability as compared to escitalopram.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effectiveness and side-effect profile of Vilazodone and Escitalopram in major Depressive Disorder – An observational study

Lella¹,

Kodali²,

Bodepudi³

et al. 2021

IJN

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“…In recent years, there was a revitalized interest in the use of IHT in children with BA. For example, researchers from Brazil studied 48 adolescents (12–14 years of age) under three conditions: mild intermittent asthma; mild persistent asthma; and control ( 72 ). They concluded that adolescents with mild persistent asthma have a greater capacity to adapt to hypoxia than do those with other types of asthma.…”

Section: Therapeutic Uses Of Intermittent Hypoxia In Pediatric Practimentioning

confidence: 99%

Intermittent Hypoxia in Childhood: The Harmful Consequences Versus Potential Benefits of Therapeutic Uses

Serebrovskaya

2015

Front. Pediatr.

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Intermittent hypoxia (IH) often occurs in early infancy in both preterm and term infants and especially at 36–44 weeks postmenstrual age. These episodes of IH could result from sleep-disordered breathing or may be temporally unrelated to apnea or bradycardia events. There are numerous reports indicating adverse effects of IH on development, behavior, academic achievement, and cognition in children with sleep apnea syndrome. It remains uncertain about the exact causative relationship between the neurocognitive and behavioral morbidities and IH and/or its associated sleep fragmentation. On the other hand, well-controlled and moderate IH conditioning/training has been used in sick children for treating their various forms of bronchial asthma, allergic dermatoses, autoimmune thyroiditis, cerebral palsy, and obesity. This review article provides an updated and impartial analysis on the currently available evidence in supporting either side of the seemingly contradictory scenarios. We wish to stimulate a comprehensive understanding of such a complex physiological phenomenon as intermittent hypoxia, which may be accompanied by other confounding factors (e.g., hypercapnia, polycythemia), in order to prevent or reduce its harmful consequences, while maximizing its potential utility as an effective therapeutic tool in pediatric patients.

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Asma, estrés oxidativo y ejercicio físico: revisión de la literatura

Rebolledo-Cobos

Corrêa

2014

Fisioterapia

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Análise de variáveis fisiológicas de adolescentes com diagnóstico clínico de asma leve intermitente ou leve persistente quando submetidos a hipóxia aguda e teste de esforço máximo

Abstract: Our findings suggest that adolescents with mild persistent asthma have a greater capacity to adapt to hypoxia than do those with other types of asthma.

Cited by 4 publications

References 17 publications

Effectiveness and side-effect profile of Vilazodone and Escitalopram in major Depressive Disorder – An observational study

Effectiveness and side-effect profile of Vilazodone and Escitalopram in major Depressive Disorder – An observational study

Intermittent Hypoxia in Childhood: The Harmful Consequences Versus Potential Benefits of Therapeutic Uses

Asma, estrés oxidativo y ejercicio físico: revisión de la literatura

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