Análise de marcadores de estabilização da placa aterosclerótica após evento coronariano agudo

Mouco, Osana M.; Nicolau, José Carlos; Souza, Tatiana da Rocha e; Maia, Lília Nigro; Ramires, José Antônio Franchini

doi:10.1590/s0066-782x2006001400005

Cited by 17 publications

(7 citation statements)

References 32 publications

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“…CRP levels in the CV group are comparable with the levels shown by Schaub et al [33]. Also, Rantes and TNF-a levels in OSA and after an acute cardiovascular event are comparable with the levels demonstrated in previous publications [22,[34][35][36]. Furthermore, IL-8 and sICAM levels in our OSA group are comparable with those published by Al Lawati et al [37].…”

Section: Inflammatory Markers After An Acute Cardiovascular Eventsupporting

confidence: 91%

“…Circulating inflammatory markers have been extensively investigated in cardiovascular disease. Indeed, these markers have been found to be key factors in cardiovascular conditions related to atherosclerosis [9] -high expression during acute cardiovascular events being correlated with poorer prognosis -and useful predictors of future events in asymptomatic patients [21][22][23][24]. In a large systematic review, long-term IL-6 levels were shown to be associated with the risk of coronary heart disease [25].…”

Section: Inflammatory Markers and Cardiovascular Diseasementioning

confidence: 99%

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Profile of circulating cytokines: Impact of OSA, obesity and acute cardiovascular events

et al. 2013

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Obstructive sleep apnea (OSA) is inducing oxidative stress and consequently promotes systemic inflammation and cardiovascular morbidity. The respective impact of obesity, sleep apnea and acute cardiovascular events on the profile of inflammatory cytokines has not been extensively evaluated. We examined the profile of circulating cytokines in a case-control study comparing nonobese or obese patients with or without sleep apnea and with or without an acute cardiovascular event. Patients were assessed by sleep studies and inflammatory (hs-CRP, Leptin, RANTES, MCP1, IL6, IL8, TNF-α) and anti-inflammatory (adiponectin, IL1-Ra) cytokines profile. A cardiovascular phenotyping was performed including carotid intima-media thickness, pulse wave velocity and 24h blood pressure monitoring. In comparison with patients without sleep apnea or without comorbidities, patients with the combination of an acute cardiovascular event and pre-existing sleep apnea showed a higher burden of systemic inflammation with significant increase in serum levels of hs-CRP, IL1-Ra, IL-8, IL-6, TNF-α, Rantes and sICAM. Rantes and sICAM serum levels were independently associated with AHI after an acute cardiovascular event. Serum levels of different inflammatory markers were significantly increased in patients with the combination of sleep apnea and an acute cardiovascular event. Since these biomarkers could be associated with worsened cardiovascular outcome, diagnosing and treating associated sleep apnea is potentially important in patients after an acute cardiovascular event.

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Section: Inflammatory Markers After An Acute Cardiovascular Eventsupporting

confidence: 91%

Section: Inflammatory Markers and Cardiovascular Diseasementioning

confidence: 99%

Profile of circulating cytokines: Impact of OSA, obesity and acute cardiovascular events

et al. 2013

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“…The average age of individuals in this study and risk factors were comparable to those of most studies of CVDs [20,21]. More women were affected; however, women typically use healthcare services more frequently than men.…”

Section: Discussionsupporting

confidence: 60%

Effects of Coronary Angioplasty on Inflammatory Markers and Lipid Profile in Patients with Cardiovascular Disease

Silva¹,

Roque²,

Moura³

et al. 2020

TOBIOMJ

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Background: Although atherosclerosis is a major cause of mortality, little is known about the role of inflammation, and mediators of disease progression. In this study, serum levels of inflammatory markers were evaluated in stable atherosclerotic disease patients before and by 24 hours after coronary angioplasty and stenting. Methods: The study included 12 patients (eight women and four men) who underwent coronary angioplasty to implant a conventional wire-mesh cobalt-chromium stent. Changes in the lipid profile were investigated. The pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukine-17 (IL-17) were measured by enzyme immunoassays. All patients received statins and reported being hypercholesterolemic, hypertensive, and sedentary. Results: TNF-α and IL-17 levels did not differ significantly before and after angioplasty. The total leukocyte count had a significant reduction when compared before (7.6; 6.5-10.6cells/µL) and after (6.78;5.2-8.2cells/µL) angioplasty, although, on the other hand, the CRP levels increased from 2.5 (0.0-14.75) to 8.0 (0.75-31mg/dL) (p<0.05). Patients had significantly higher average total cholesterol before (160; 148-193) then after (155; 122-172mg/dL) (p=0.0038), as well as HDL-cholesterol, before (41; 30-49) and after (33; 32-42mg/dL) (p=0.0192), and apolipoprotein-A levels, before (159;133-169) and after, (143; 115-150 mg/dL) (p<0.05) procedure. On the other hand, no significant differences were noticed on LDL-cholesterol, triglycerides, and apolipoprotein-B concentrations. Conclusion: The angioplasty procedure with stent implantation influenced lipoprotein metabolism specifically that of HDL, by leading to HDL-c and apolipoprotein-A reductions, as well as total leukocyte count, and CRP elevations by 24 hours after procedure.

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“…MI results from thrombus formation in coronary blood vessels. Such thrombus may cause a stable coronary atherosclerotic lesion to transform into a ruptured plaque [ 3 ]. The process of thrombus formation depends on a number of factors that include inflammatory cells, endothelium, endothelin, cytokines, metalloproteinases, cholesterol and platelets, T-lymphocytes, and phospholipase A2 [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism Increases Myocardial Infarction Risk: A Meta-Analysis

et al. 2017

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BackgroundPolymorphisms of the endothelial nitric oxide synthase (eNOS) gene are reportedly associated with myocardial infarction (MI) risk. However, definitive evidence of this association is lacking. In this study, we investigated the potential association of eNOS gene polymorphisms with MI risk by conducting a meta-analysis of studies evaluating this association.Material/MethodsPubMed, Web of Knowledge, ScienceDirect, China National Knowledge Infrastructure (CNKI), WanFang, and Database of Chinese Scientific and Technical Periodicals (VIP) were searched for relevant studies. Pooled odds ratios (OR) with 95% confidence interval (CI) were calculated to evaluate the association of eNOS gene T-786C and 4b4a polymorphisms with MI risk.ResultsFifteen studies with 8,067 controls and 4,923 MI cases were included in the final meta-analysis. In the overall analysis, T-786C (rs2070744) polymorphism was associated with MI risk (p<0.05, OR=1.69, 95% CI: 1.53–1.86 for T vs. C; p<0.05, OR=2.76, 95% CI: 2.03–3.75 for TT vs. CC; p<0.05, OR=1.74, 95% CI 1.56–1.95 for TT vs. (CT + CC); p<0.05, OR=2.43, 95% CI: 1.79–3.30 for (CT + TT) vs. CC). In addition, a significant association between 4b4a VNTR polymorphism and MI risk was observed. On sub-group analyses by ethnicity, a significant increase in MI risk was observed separately for Asian and Caucasian populations for T-786C polymorphism, but not for the 4b4a polymorphism.ConclusionsIn this meta-analysis, T-786C polymorphism of the eNOS gene was associated with the risk of MI, especially in the Asian populations.

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Análise de marcadores de estabilização da placa aterosclerótica após evento coronariano agudo

Cited by 17 publications

References 32 publications

Profile of circulating cytokines: Impact of OSA, obesity and acute cardiovascular events

Profile of circulating cytokines: Impact of OSA, obesity and acute cardiovascular events

Effects of Coronary Angioplasty on Inflammatory Markers and Lipid Profile in Patients with Cardiovascular Disease

The Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism Increases Myocardial Infarction Risk: A Meta-Analysis

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