Análise das internações e da mortalidade por doenças febris, infecciosas e parasitárias durante a pandemia da COVID-19 no Brasil

Dias, Nikolas Lisboa Coda; Faccini-Martínez, Álvaro A.; Oliveira, Stefan Vilges de

doi:10.31005/iajmh.v4i.173

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…The identification of asymptomatic and oligosymptomatic patients is challenging. These patients might be diagnosed as having other illnesses, as the symptoms of COVID-19 are very similar to common respiratory infections [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Prevalence, under-reporting, and epidemiological surveillance of COVID-19 in the Araguaína City of Brazil

Oliveira,

Carvalho,

Meurer

et al. 2024

PLoS ONE

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Asymptomatic and underreported individuals remain a source of coronafig disease 2019 (COVID-19) transmission to others. Data on the prevalence and epidemiological factors influencing transmission are fundamental for establishing control measures, especially in vulnerable regions such as the Amazon. This study aimed to determine the point prevalence and active infection of COVID-19 among the population in Araguaína, a Brazilian city located in the Amazon region, analyzed the socioeconomic and behavioral variables of a statistically representative sample of this population using an epidemiological survey, and identify the viral genomic diversity in the region. During the sixth epidemiological week of 2021 (February 8 to 12), samples of 497 inhabitants of the municipality asymptomatic for respiratory syndromes underwent reverse transcription-quantitative polymerase chain reaction and serological tests (immunoglobulin M and immunoglobulin G). A questionnaire collated data on socioeconomic factors, prevention measures, and health status history. The active infection rate was 6.2%, and the prevalence was 13.5% of the study population. Active infection cases were under-reported; each reported positive case represented 14–28 under-reported cases. Lineages P.2, P.1, and B.1.1 were detected. Working from home was a protective factor against the infection, and clinical signs of fever, dry cough, and loss of taste or smell were associated with testing positive (p <0.05). A descriptive analysis of the indicators revealed that the entire population was susceptible to the disease. Intensified vaccination strategies are required regardless of socioeconomic factors, health conditions, and preventive measures. Implementation of objective, comprehensive, and efficient management tools to minimize the spread of COVID-19 in this municipality can serve as a model for other regions of Brazil.

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Section: Introductionmentioning

confidence: 99%

Prevalence, under-reporting, and epidemiological surveillance of COVID-19 in the Araguaína City of Brazil

Oliveira,

Carvalho,

Meurer

et al. 2024

PLoS ONE

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“…No Brasil, ainda não existe imunização contra a leptospirose, nesse sentido, a melhor forma para prevenir da doença são as ações de prevenção e educação voltadas para reduzir os fatores de risco e comportamentos que possam potencializar a infecção. 45,35 Diante do exposto, torna-se fundamental contribuir para a proposição de medidas de promoção da saúde e prevenção de zoonoses nas prisões com a finalidade de aumentar o estado de saúde e minimizar os riscos de adoecimento. Ademais, para os casos suspeitos, deve-se notificar o serviço de vigilância epidemiológica local para que sejam adotadas medidas de monitoramento e intervenção assertivas.…”

Section: Introductionunclassified

Risk factors for leptospira infection in female prison in Mato Grosso

Santos

Terças-Trettel²,

Graça³

et al. 2023

Rev. Pre Infec e Saúde

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Introduction: Incarcerated women are exposed to a potential environment precursor of risk for various types of illnesses, including leptospirosis. Aim: To identify the risk factors for Leptospira infection in female prison in the state of Mato Grosso (MT). Outlining: This is a quantitative open cohort study conducted between the years 2016, 2017 and 2018 in the Female Public Prison of a municipality in the middle-north region of MT. Results: Although there was no detection of seroreactivity among the incarcerated women, the profile points to young women, with a mean age of 31.45 years, brown, single, with education that did not exceed elementary school, with children and low income. Rodent contact was evidenced prior to incarceration, as well as in the prison environment by viewing the animal or its excreta, which may suggest the close and daily relationship between these women and rodents. Implications: The presence of the previous risk and during imprisonment reinforce the vulnerabilities to which these women are exposed from social interaction to the context of imprisonment, being fundamental propositions of health promotion and prevention of zoonoses in prisons.

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“…The World Health Organization (WHO) defines neglected tropical diseases (NTDs) as a group of diseases that are prevalent in the poorest regions of the world, where access to healthcare, sanitation and safe drinking water is inadequate [ 1 ]. During the COVID-19 pandemic, there has been a rise in mortality rates from NTDs due to insufficient support for affected individuals, who are often among the most vulnerable populations [ 2 ]. This reinforces what the Drugs for Neglected Diseases initiative (DNDi) has confirmed: there are no neglected diseases, only neglected patients [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Antileishmanial Activity, Toxicity and Mechanism of Action of Complexes of Sodium Usnate with Lanthanide Ions: Eu(III), Sm(III), Gd(III), Nd(III), La(III) and Tb(III)

da Silva,

Rizk,

das Neves

et al. 2023

IJMS

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Leishmaniases are neglected diseases with limited therapeutic options. Diffuse cutaneous leishmaniasis can occur in Brazil due to Leishmania amazonensis. This study details the antileishmanial activity and cytotoxicity of complexes of sodium usnate (SAU) with lanthanide ions ([LnL3 (H2O)x] (Ln = La(III), Nd(III), Gd(III), Tb(III), Eu(III) and Sm(III); L = SAU). All lanthanide complexes were highly active and more potent than SAU against L. amazonensis promastigotes and intracellular amastigotes (Pro: IC50 < 1.50 μM; Ama: IC50 < 7.52 μM). EuL3·3H2O and NdL3·3H2O were the most selective and effective on intracellular amastigotes, with a selectivity index of approximately 7.0. In silico predictions showed no evidence of mutagenicity, tumorigenicity or irritation for all complexes. Treatment with EuL3·3H2O triggered NO release even at the lowest concentration, indicating NO production as a mechanism of action against the parasite. Incubating promastigotes with the lanthanide complexes, particularly with SmL3·4H2O and GdL3·3H2O, led to a change in the mitochondrial membrane potential, indicating the ability of these complexes to target this essential organelle. The same complexes caused cell death through cell membrane disruption, but their relationship with early or late apoptotic processes remains unclear. Thus, the inclusion of lanthanide ions in SAU improves selectivity with a promising mechanism of action targeting the mitochondria.

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Análise das internações e da mortalidade por doenças febris, infecciosas e parasitárias durante a pandemia da COVID-19 no Brasil

Cited by 3 publications

References 9 publications

Prevalence, under-reporting, and epidemiological surveillance of COVID-19 in the Araguaína City of Brazil

Prevalence, under-reporting, and epidemiological surveillance of COVID-19 in the Araguaína City of Brazil

Risk factors for leptospira infection in female prison in Mato Grosso

Antileishmanial Activity, Toxicity and Mechanism of Action of Complexes of Sodium Usnate with Lanthanide Ions: Eu(III), Sm(III), Gd(III), Nd(III), La(III) and Tb(III)

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