Análise das atividades farmacológicas da Handroanthus serratifolius (Vahl) S.Grose

Macedo, Fernanda Arias de Almeida; Coêlho, Mayara Ladeira; Ribeiro, Manoela Cavalcante; Barros, Elcio Daniel Sousa; Gomes, João Paulo da Silva; Batista, Ceres Lima; Lima, Layana Karine Farias; Sousa, Renato Pinto de

doi:10.33448/rsd-v11i2.22891

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Another example is the lapachol, compound derived from naphthoquinones and that can be extracted from the bark of Tabebuia avellanedae (ipê roxo) and has antifungal activity through of oxidative stress (Lira et al, 2022;Macêdo et al, 2022) in addition to having anticancer, analgesic and antineoplastic properties.…”

Section: Introductionmentioning

confidence: 99%

An in silico study involving Mangiferin, 7-Epiclusianone, Fukugetin, Lapachol, Plumbagin and Guttiferone-A against C. albicans proteins

Barros¹,

Araújo²,

Silveira³

et al. 2023

NRFHH

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It is notorious that since the beginnings of spacetime, the human being lives with microorganisms of countless forms, be it in a positive way as in case of Bacteroidetes present in the intestine’s microbiota or negative way as in case of recent epidemic of Sars-Cov-2. So, the negative impacts caused by microorganisms are objects of study in the whole world, for instance, Candida albicans, which is a fungus that lives in the human body symbiotically and assists in the maintenance of body homeostasis, but the same can present an invasive features that become harmful to the human health, mainly in people who present some kind of immunodeficiency, causing its proliferation to become exacerbated, may cause the death. Said that, the use of drugs to control C. albicans is very important, being the nystatin and fluconazole that are the ones that are currently used. However, the updating of such medicines as time goes by becomes ineffective to some kinds of strains, since the capacity of the fungus in evolution creates resistance to medicines. So, the Discovery of new drugs is necessary and natural products are an excellent research source for the same. Therefore, this study made the methodology in silico of molecular docking to investigate the forms of connection of the natural compounds fukugetin, guttiferone-A, lapachol, mangiferin, plumbagin and 7-epiclusianone in potential molecular targets of fungus Candida albicans.

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Section: Introductionmentioning

confidence: 99%

An in silico study involving Mangiferin, 7-Epiclusianone, Fukugetin, Lapachol, Plumbagin and Guttiferone-A against C. albicans proteins

Barros¹,

Araújo²,

Silveira³

et al. 2023

NRFHH

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“…This species is native to South America, with a wide distribution in Brazil and a long history of use in reforestation and landscaping. The wood has high commercial value, while the leaves and flowers present pharmacological potential [ 18 , 19 , 20 , 21 ]. Despite its importance, there are very few reports in the literature of studies involving AM fungi and H. serratifolius .…”

Section: Introductionmentioning

confidence: 99%

Arbuscular Mycorrhizal Fungi Promote Physiological and Biochemical Advantages in Handroanthus serratifolius Seedlings Submitted to Different Water Deficits

Correia

Lara

Santos

et al. 2022

Plants

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Climate change causes increasingly longer periods of drought, often causing the death of plants, especially when they are in the early stages of development. Studying the benefits provided by arbuscular mycorrhizal (AM) fungi to plants in different water regimes is an efficient and sustainable strategy to face climate change. Thus, this study investigated the influence of AM fungi on Handroanthus serratifolius seedlings under different water regimes, based on biochemical, and nutritional growth parameters. The experiment was carried out in H. serratifolius seedlings cultivated with mycorrhizas (+AMF) and without mycorrhizas (-AMF) in three water regimes; a severe water deficit (SD), a moderate water deficit (MD), and a well-watered (WW) condition. AM fungi provided greater osmoregulation under water deficit conditions through the accumulation of soluble sugars, total free amino acids, and proline, as well as by reducing sugar. The increase in the absorption of phosphorus and nitrate was observed only in the presence of fungi in the well-watered regimen. A higher percentage of colonization was found in plants submitted to the well-watered regimen. Ultimately, AM fungi promoted biochemical, nutritional, and growth benefits for H. serratifolius seedlings under the water deficit and well-hydrated conditions, proving that AMF can be used to increase the tolerance of H. serratifolius plants, and help them to survive climate change.

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Influence of arbuscular mycorrhizal fungi density on growth and metabolism of Handroanthus serratifolius (Vahl) S.O. Grose seedlings

da Sousa,

Correia,

dos Farias

et al. 2023

Physiologia Plantarum

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Studies on the relationship between Handroanthus serratifolius and arbuscular mycorrhizal fungi (AMF) are limited in the literature. The influence of AMF spore density on plant development is fundamental information to determining the degree of benefits in this relationship. Therefore, the objective of this study was to investigate the effects of different AMF spore densities on thirty‐day‐old H. serratifolius seedlings, focusing on growth and biochemical parameters using a completely randomized experimental design with three different spore densities and control. The spore densities were classified as low, medium, and high, with 1.54, 3.08, and 12.35 spores g−1, respectively. Plant growth analysis, mycorrhizal colonization, nitrogen compound concentration, and carbohydrate analysis were performed. The medium spore density treatment showed the greatest increases in biomass, height, leaf area, and root volume. Furthermore, greater absorption of phosphorus and better dynamics in nitrogen metabolism were observed in mycorrhizal plants compared to the control since the ammonium and nitrate compounds were rapidly incorporated into protein and chlorophyll compounds. The carbohydrate analysis revealed the influence of source‐sink dynamics on sugar concentration in different plant parts. These findings support the importance of determining the appropriate spore density for assessing the symbiotic relationship between forest species and AMF.

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Análise das atividades farmacológicas da Handroanthus serratifolius (Vahl) S.Grose

Cited by 3 publications

References 17 publications

An <i>in silico</i> study involving Mangiferin, 7-Epiclusianone, Fukugetin, Lapachol, Plumbagin and Guttiferone-A against <i>C. albicans</i> proteins

An <i>in silico</i> study involving Mangiferin, 7-Epiclusianone, Fukugetin, Lapachol, Plumbagin and Guttiferone-A against <i>C. albicans</i> proteins

Arbuscular Mycorrhizal Fungi Promote Physiological and Biochemical Advantages in Handroanthus serratifolius Seedlings Submitted to Different Water Deficits

Influence of arbuscular mycorrhizal fungi density on growth and metabolism of Handroanthus serratifolius (Vahl) S.O. Grose seedlings

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