Análise comparativa do fractional flow reserve (FFR) e do instantaneous wave‐free ratio (iFR): resultados de um registo de 5 anos

Menezes, Miguel Nobre; Francisco, Ana Rita G.; Ferreira, Pedro Carrilho; Jorge, Cláudia; Torres, Diogo; Cardoso, Pedro; Duarte, Joana; Costa, J. M. Da; Oliveira, Eduardo Infante de; Pinto, Fausto J.; Silva, Pedro Canas da

doi:10.1016/j.repc.2017.11.011

Cited by 11 publications

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“…This value is slightly higher than reported in previous studies [ 34 ]. However, other studies reported a higher [ 15 ] and a similar optimal cut-off value when comparing FFR with iFR [ 35 ]. Similarly, the optimal cut-off value for FFR to detect significant ischemia based on iFR/RFR (iFR/RFR ≤ 0.89) was 0.82.…”

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confidence: 87%

Comparison of Fractional Flow Reserve with Resting Non-Hyperemic Indices in Patients with Coronary Artery Disease

Zdzierak¹,

Zasada

Krawczyk‐Ożóg

et al. 2023

JCDD

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Guidelines recommend using hyperemic (FFR) and non-hyperemic (iFR/RFR) methods of evaluating coronary artery stenoses in patients with coronary artery disease. However, in some cases, achieved results indicating significant ischemia may differ between those methods. Thus, we sought to identify predictors of such a discrepancy. Data were collected on all consecutive patients with chronic coronary syndrome hospitalized between 2020 and 2021. For 279 patients (417 vessels), results for both FFR and iFR/RFR were available. Values of ≤0.80 for FFR and ≤0.89 for iFR/RFR were considered positive for ischemia. Discordant measurements of FFR and iFR/RFR were observed in 80 (19.2%) patients. Atrial fibrillation was the only predictor of the overall FFR and iFR/RFR discordance - OR (95%CI) 1.90 (1.02–3.51); p = 0.040. The chance of positive FFR and negative iFR/RFR decreased independently with age - OR (95%CI) 0.96 (0.93–0.99); p = 0.024. On the contrary, insulin-treated diabetes mellitus was the predictor of negative FFR and positive iFR/RFR discrepancy - OR (95%CI) 4.61 (1.38–15.40); p = 0.013. In everyday clinical practice, iFR/FFR correlates well with FFR. However, discordance between these methods is quite common. Physicians should be aware of the risk of such discordance in patients with atrial fibrillation, advanced age, and insulin-treated diabetes mellitus.

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