Analgetic effect of ozone therapy: myths of reality?

Abstract

Introduction: Administration of an oxygen-ozone mixture is one of the innovative techniques used in single-drug or complex therapeutic schemes for treatment of many degenerative-dystrophic pathologies of the musculoskeletal system and related neurological complications. Aim: The aim was to determine the mechanisms of physiological action of the oxygen-ozone mixture in order to substantiate its efficacy for treatment of chronic pain syndrome with underlying degenerative-dystrophic pathologies of the musculoskeletal system. Material and methods: The article covers biochemical and pathomorphological studies that explain the mechanism of the pain syndrome and the potential effect of the ozone therapy. Results and discussion: The treatment schemes and benefits of different routes of ozone administration (intramuscularly, intravenously, intradiscally and intraarticularly) were analyzed. Diverse research data demonstrated influence on the causes of chronic pain, pathophysiological phases, and possible complications. The prospects of further studies for development of the most effective techniques for treatment of various pain syndromes were assessed. Conclusions: Ozone therapy is one of the alternative rehabilitation methods with a substantial pain relieving effect. As of today, the possibility of using the oxygen-ozone mixture for treatment of chronic back pain related to intervertebral disk hernia and fibromyalgia has been substantially confirmed.

Експериментальна Оцінка Ефективності Озонотерапії В Лікуванні Гострого Порушення Мозкового Кровообігу За Ішемічним Типом

“…Озон має імуномодулюючу дію, стимулює клітинний та гуморальний імунітет, фагоцитарну функцію, блокує ангіотензинперетворюючий фермент тощо. Загалом багато досліджень показали позитивний ефект озонотерапії як додаткової терапії [9,10].…”

Експериментальна Оцінка Ефективності Озонотерапії Збалансованими Кристалоїдними Розчинами В Лікуванні Гострого Порушення Мозкового Кровообігу За Ішемічним Типом

“…Озон має імуномодулюючу дію, стимулює клітинний та гуморальний імунітет, фагоцитарну функцію, блокує ангіотензинперетворюючий фермент тощо. Загалом багато досліджень показали позитивний ефект озонотерапії як додаткової терапії [10,11].…”

Cognitive, neuropsychological and biological effects of Oxygen-Ozone Therapy in frailty: a 5-week, randomized, placebo-controlled trial

“…Since 1840, from its discovery, ozone (O3) and consequently the oxygen (O2)-O3 therapy expand into the medical field giving rise to compelling research in the recent decades to validate its clinical value [19]. Several papers [20][21][22] emphasized its relevant medical features, including virucidal and bactericidal effects, inflammatory modulation and circulatory stimulation, with considerable applications in several medical fields [23]. The function of O3 is strictly associated to its power to directly interact with phospholipids, lipoproteins, bacteria envelopes and viral capsids.…”