Analgesics and the kidney: Summary and recommendations to the Scientific Advisory Board of the National Kidney Foundation from an ad hoc Committe of the National Kidney Foundation

Henrich, William L.; Agodoa, Lawrence E.; Barrett, Brendan; Bennett, William M.; Blantz, Roland C.; Buckalew, Vardaman M.; D’Agati, Vivette D.; DeBroe, Marc E.; Duggin, Geoffrey G.; Eknoyan, Garabed; Elseviers, Monique; Gómez, Rafael; Matzke, Gary R.; Porter, George A.; Sabatin, Sandra; Stoff, Jeffrey S.; Striker, Gary E.; Winchester, James F.

doi:10.1016/s0272-6386(96)90046-3

Cited by 163 publications

(79 citation statements)

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“…Non-ESRD-specific conditions such as fatigue, pain, and depression are as prevalent as ESRD-specific conditions (anemia, renal osteodystrophy, access, adequacy, etc.) and thus are deserving of equal attention by guideline committees (36). In fact, the former may be more important to patients than the latter.…”

Section: Discussionmentioning

confidence: 99%

Opioid and Benzodiazepine Use in End-Stage Renal Disease

Wyne

Rai

Cuerden

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Chronic pain and psychiatric disorders are common in dialysis patients, but the extent to which opioids and benzodiazepines are used is unclear. We conducted a systematic review to determine the: (1) prevalence of opioid and benzodiazepine use among dialysis patients; (2) reasons for use; (3) effectiveness of symptom control; and (4) incidence of adverse events.Design, setting, participants, & measurements Two authors reviewed all relevant citations in MEDLINE/ EMBASE/CINAHL/BIOSIS Previews/Cochrane and hand-searched bibliographies. Studies after 1990 reporting prevalence estimates for opioid and/or benzodiazepine use in Ն50 dialysis patients were included. ResultsWe identified 15 studies from 12 countries over 1995 to 2006. Sample size ranged from 75 to 12,782. Prevalence of opioid and benzodiazepine use was variable, ranging from 5 to 36% (95% CI, 4.1 to 45.5%; n ϭ 10) and 8 to 26% (95% CI, 7.1 to 27.3%; n ϭ 9), respectively. Prevalence was positively correlated with years on dialysis. Five studies reported on the same cohorts but gave different prevalence estimates. One study verified medication use through patient interviews. Reasons for use were reported in one study. Effectiveness of pain control varied from 17 to 38%, and 72 to 84% of patients with significant pain had no analgesia (n ϭ 2). No study rigorously examined for adverse events. ConclusionsThe prevalence of opioid and benzodiazepine use in dialysis patients is highly variable between centers. Further information is needed regarding the appropriateness of these prescriptions, adequacy of symptom control, and incidence of adverse effects in this population.

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Section: Discussionmentioning

confidence: 99%

Opioid and Benzodiazepine Use in End-Stage Renal Disease

Wyne

Rai

Cuerden

et al. 2011

Clinical Journal of the American Society of Nephrology

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“…Some Phytochemical studies have reported that certain Indian medicinal plants show beneficial effects on kidney and renal injury 5,6 . Research into the etiopathological basis of Cisplatin nephrotoxicity has recently been encouraged 7 .…”

Section: Issn: 0975-8232mentioning

confidence: 99%

Untitled

2011

IJPSR

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Aim of the study: Now a days due to the hammering of movies and fashion most of the people specifically age group between 18 to 30 years, are diverted more to have the protein supplements in excess for getting good physique and well toned body shape. The people suppose to eat more calcium, vitamins and some steroids with intension that they will get done the things too fast. Without been having good trainee and medical supervisor most of the people doing exercise in the fitness club and gym and taking the diet which is one of the major cause of nephrotoxicity. Materials and Methods: Ethanolic extract of stem barks of Crataeva nurvulaBuch hum in the doses of 200 mg, 400 mg and 600 mg is useful as a laxative, demulcent, stomachic, and is reported to cure disorders of urinary organs. It is also very useful as anti-inflammatory drug and act as a good contraceptive for women and also used in arthritis.

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“…An acute acetaminophen (paracetamol, N-acetyl p-aminophenol; APAP) overdose may result in a potentially fatal hepatic and renal necrosis in humans and experimental animals (Jones and Vale, 1999). Etiopathological basis of acetaminophen nephrotoxicity has recently been used for kidney disease research (Henrich et al, 1996). It is necessary to establish proper doses and durations of acetaminophen for inducing nephrotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Acetaminophen Induced Kidney Failure in Rats: A Dose Response Study

Roy¹,

Pradhan²,

Das³

et al. 2015

J. of Biological Sciences

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A B S T R A C TAcetaminophen is a commonly used analgesic and antipyretic drug, high doses of which cause hepatic and renal injury. In development and progression of kidney disease research, it is necessary to have a suitable common drug to induce uremia and renal failure of rats. It is also required to select the threshold doses for the said drug; a therapeutic dose and toxic dose for kidney failure using standard guidelines. An acute toxicity of acetaminophen was conducted by the limit test at a dose of 2000 mg kgG 1 b.wt., on either sex rats (n = 5) and a main test was conducted by a dose progression factor of 3.2 times as per Organization of Economic Co-Operation and Development guidelines 425. Eighteen male albino rats (n = 18) were divided into three groups, group I served as control, groups II and III rats were administered 175 mg and 550 mg kgG 1 b.wt., acetaminophen intraperitoneally for 14 days, respectively. Different parameters were considered to analyze renal failure. Urea, creatinine, GOT, GPT and MDA levels were increased significantly (p<0.05) in group III, compared to groups I and II. Antioxidant enzymes like SOD, catalase and GSH level were decreased significantly (p<0.05) in group III rats, compared to group I and II rats. Increase in blood uremia profile indicated that the higher dose of acetaminophen causes uremia. Increase in the toxicity markers and lipid peroxidation marker enzymes indicate the nephrotoxicity. Histological structures of kidney of group III animals showed a severe disorganization of glomerulus and dilation of renal tubules. These results indicate that intraperitoneal injection of acetaminophen at high dose causes nephrotoxicity and renal cellular damage to experimental rats.

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Analgesics and the kidney: Summary and recommendations to the Scientific Advisory Board of the National Kidney Foundation from an ad hoc Committe of the National Kidney Foundation

Cited by 163 publications

References 1 publication

Opioid and Benzodiazepine Use in End-Stage Renal Disease

Opioid and Benzodiazepine Use in End-Stage Renal Disease

Untitled

Acetaminophen Induced Kidney Failure in Rats: A Dose Response Study

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