Analgesic substances derived from natural products (natureceuticals)

McCurdy, Christopher R.; Scully, Stephen S.

doi:10.1016/j.lfs.2005.09.006

Cited by 85 publications

(67 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4,19,20) Despite the absence of experimental studies concerning the analgesic properties of R. rosaefolius, other plants of the Rubus genus have exhibited important antinociceptive effects in mice. 6,12) Table 1 shows that the hydroalcoholic extract and any fractions caused a pronounced effect when analysed against writhing model in mice.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical and Analgesic Activity of Extract, Fractions and a 19-Hydroxyursane-Type Triterpenoid Obtained from Rubus rosaefolius (Rosaceae)

Kanegusuku

Sbors

Bastos

et al. 2007

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Rosaceae consists of a large family of plants, represented by fruits such as plums, cherries, damson plums, quinces, strawberries, pears and peaches.1) The plants to the genus Rubus, have been traditionally used to treat different diseases, particularly diabetes.2-4) Chemical and pharmacological studies have shown that some species produce active principles that exert antigastropathic, antiinflammatory, antioxidant activity.5-7) Besides these activities, it has been reported that extracts of some species of this genus are potential antimicrobial and analgesic sources. [8][9][10] Phytochemical studies carried out with these plants indicate the presence of steroids, triterpene and ellagic acid derivatives. 8,9,11) Recently, we have shown that another species, R. imperialis, presents hypoglycaemic, cytotoxic and antinociceptive actions. 9,[11][12][13] The main isolated active compound, named niga-ichigoside F1, showed marked antinociception and its mechanism of action appears to be related to the dopaminergic, cholinergic, glutamatergic, and tachykininergic and oxinitrergic systems. 14)Rubus rosaefolius, popularly known as "amora-do-mato" or "amora-vermelha" in Brazil, is a shrub measuring between 4 and 5 m, and is well distributed in the South of Brazil. 1,15) The current study extends our previous work on the biological properties of the Rubus species, and describes its phytochemical analysis and in vivo antinociceptive activity against two pain models in mice (writhing and formalin tests) of the extract, fractions and a pure compound isolated from the aerial parts of R. rosaefolius. Phytochemical Analysis Air-dried material from R. rosaefolius (700 g) was cut into small pieces and macerated with methanol at room temperature for 7 d. After filtration, the solvent was removed by rotatory evaporation under reduced pressure, yielding the respective methanolic extract (ME). Parallel to this, a hydroalcoholic extract (HE) was prepared through maceration of 100 g of plant with an ethanol-water (50 : 50) mixture and stored for use in the pharmacological test. The methanolic extract (35 g), were then suspended in a MeOH : water mixture (9 : 1) and successively partitioned with n-hexane, dichlomethane, ethyl acetate and n-butanol, to provide the respective fractions. The hexane and dichloromethane fractions (7.4, 4.2 g) were chromatographed on silica gel column eluted with a hexane : acetone mixture with increasing polarity. Similar fractions, which showed a positive reaction with anisaldehyde sulfuric reagents, were combined and rechromatographed as in the The Rubus species has been used in folk medicine to treat several ailments, including infectious and dolorous diseases. In this work we evaluate the phytochemical and analgesic activity of hydroalcoholic extract (HE), some fractions (hexane, dichloromethane, ethyl acetate and butanolic), as well as a pure compound denoted as 28-methoxytormentic acid (1) obtained from aerial parts of R. rosaefolius. The compounds were isolated and identified by chromatographic and spect...

show abstract

Section: Resultsmentioning

confidence: 99%

Phytochemical and Analgesic Activity of Extract, Fractions and a 19-Hydroxyursane-Type Triterpenoid Obtained from Rubus rosaefolius (Rosaceae)

Kanegusuku

Sbors

Bastos

et al. 2007

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…The research of medicinal plants can propitiate the discovery of new molecules with innovative mechanisms or less adverse side effects (McCurdy & Scully, 2005). Euphorbiaceae family is well known between the medicinal plants with more than 8,000 species vastly distributed in tropical and temperate regions of the world (Wilson et al, 1979;Agra et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae)

Rocha¹,

Neto-Neves²,

Costa³

et al. 2008

Rev. bras. farmacogn.

View full text Add to dashboard Cite

RESUMO: "Avaliação dos efeitos antinociceptivo e antiinfl amatório de Croton pullei var. glabrior Lanj. (Euphorbiaceae)". Croton pullei var. glabrior Lanj. (Euphorbiaceae) é uma liana, amplamente distribuída na Floresta Amazônica. Na medicina popular, diversas plantas do gênero Croton têm sido utilizadas com fi ns terapêuticos em patologias que envolvem dor e infl amação, o que justifi ca este trabalho. O objetivo deste estudo foi investigar as atividades antinociceptiva e antiinfl amatória do extrato metanólico das folhas de C. pullei (MECP). O MECP reduziu, de forma dose-dependente, o número de contorções abdominais (1,2 %) em camundongos, sugerindo uma atividade antinociceptiva da planta. Por outro lado, o MECP não alterou signifi cativamente a reatividade ao estímulo térmico no teste da placa quente e a reatividade à estimulação química na primeira fase do teste da formalina, indicando um mecanismo não-opioidérgico. O MECP reduziu a nocicepção na segunda fase do teste da formalina, inibiu o edema de orelha induzido pelo óleo de croton e reduziu a migração leucocitária no teste da peritonite induzida por carragenina, indicando uma atividade antiinfl amatória. Apesar dos mecanismos responsáveis pelos efeitos da planta ainda não estarem completamente esclarecidos, estes resultados parecem justifi car o uso medicinal potencial de Croton pullei var. glabrior Lanj. em patologias que envolvam dor e infl amação.Unitermos: Antiinfl amatório, antinociceptivo, Croton pullei var. glabrior, fi tomedicina. ABSTRACT:Croton pullei var. glabrior Lanj. (Euphorbiaceae) is a liana, vastly distributed in the Amazonian Forest. In the folk medicine, several plants of the Croton genus have been used with therapeutic purposes in pathologies that involve painful and infl ammatory diseases which justify this work. The aim of this study was to investigate the antinociceptive and antiinfl ammatory activities of the C. pullei leaves methanol extract (MECP). MECP reduced in a dose-dependent manner the number of acetic acid-induced abdominal writhing (1.2%) in mice, suggesting an antinociceptive activity of the plant. On the other hand, MECP did not signifi cantly modify the reactivity to the thermal stimulation in the hot-plate test and the reactivity to the chemical stimulation in the formalin test fi rst phase, indicating a non-opioid mechanism. MECP reduced the formalin-induced nociception in the second phase, inhibited the croton oil-induced ear edema and reduced the leukocytes migration in the test of the carrageenan-induced peritonitis, indicating an antiinfl ammatory activity. Although the mechanisms that underlie these plant effects are not completely elucidated, these results appear to support the potential medicinal use of Croton pullei var. glabrior Lanj. against painful and infl ammatory diseases.

show abstract

“…These are derived from opium juice from Papaver somniferum; examples of these groups of drugs include morphine, codeine and thebaine. These drugs are also use for recreational purposes apart from their use as analgesics (McCurdy and Scully, 2005). Cocaine interact with voltage-gated ion channels and blocks sodium channels which is responsible for its local anaesthetic activity.…”

Section: Analgesia and Recreactionmentioning

confidence: 99%

“…Cocaine interact with voltage-gated ion channels and blocks sodium channels which is responsible for its local anaesthetic activity. Cocaine has the ability to block the dopamine transporter due to its ability to create a euphoric state, meaning it is also use for recreational purposes (McCurdy and Scully, 2005). Caffeine is the most widely used psychoactive drug in the world, found in a number of plant sources.…”

Section: Analgesia and Recreactionmentioning

confidence: 99%

From Nutrition to Health: The Role of Natural Products – A Review

Mikail¹

2011

Phytochemicals - Bioactivities and Impact on Health

View full text Add to dashboard Cite

Analgesic substances derived from natural products (natureceuticals)

Cited by 85 publications

References 45 publications

Phytochemical and Analgesic Activity of Extract, Fractions and a 19-Hydroxyursane-Type Triterpenoid Obtained from Rubus rosaefolius (Rosaceae)

Phytochemical and Analgesic Activity of Extract, Fractions and a 19-Hydroxyursane-Type Triterpenoid Obtained from Rubus rosaefolius (Rosaceae)

Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae)

From Nutrition to Health: The Role of Natural Products – A Review

Contact Info

Product

Resources

About