Analgesic Peptides: From Natural Diversity to Rational Design
Katarzyna Gach-Janczak,
Monika Biernat,
Mariola Kuczer
et al.
Abstract:Pain affects one-third of the global population and is a significant public health issue. The use of opioid drugs, which are the strongest painkillers, is associated with several side effects, such as tolerance, addiction, overdose, and even death. An increasing demand for novel, safer analgesic agents is a driving force for exploring natural sources of bioactive peptides with antinociceptive activity. Since the G protein-coupled receptors (GPCRs) play a crucial role in pain modulation, the discovery of new pe… Show more
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