Analgesic interaction between ondansetron and acetaminophen after tonsillectomy in children: The <scp>P</scp>aratron randomized, controlled trial

Ramirez, L.; Cros, Jérôme; Marin, Benoît; Boulogne, Pieter; Bergeron, Anne; Lafont, G.E. de; Renon-Carron, Françoise; Vinzelles, M-A. de; Guigonis, Vincent; Nathan, Nathalie; Beaulieu, Pierre

doi:10.1002/ejp.587

Cited by 22 publications

(10 citation statements)

References 28 publications

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“…In this study, subjects were in a similar status in terms of demographic variables in order to reduce bias in the results. This finding was in line with the findings of the study by Ramirez et al [6]. Surprisingly, the frequency of nausea in the recovery unit was significantly higher in the intervention group who received ondansetron, an antiemetic drug plus acetaminophen compared to the control group but this difference was not significant in later assessments.…”

Section: Discussionsupporting

confidence: 91%

“…Sample size was calculated based on the findings of the study by Ramirez et al [6], which reported the percentage of opioid administration in patients who received acetaminophen and ondansetron as 57.1% and in patients who received acetaminophen alone as 20.6%, considering power = 80% and alpha error = 0:05 using the following inequality equation two sided; the sample size was calculated as 23 patients in each group.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, tonsillectomy is suggested for children with recurrent episodes of inflammation and infection in tonsils for consecutive years [4]. Tonsillectomy is one of the most frequent pediatric surgeries in the United States, and 530000 tonsillectomy operations are performed annually in the United States [5,6].…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Ondansetron on the Analgesic Action of Intravenous Acetaminophen after Tonsillectomy in Children: A Triple‐Blind Randomized Controlled Trial

Nikooseresht

Nasrolahi

Hajian

et al. 2021

Oxidative Medicine and Cellular Longevity

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Introduction. Severe pain, nausea, and vomiting after tonsillectomy surgery are among the issues that not only affect patient satisfaction but also may result in complications and delay patient discharge. This study was conducted to assess the effect of intravenous administration of ondansetron on the analgesic action of intravenous acetaminophen after tonsillectomy in children. Materials and methods. This randomized controlled trial was conducted on 53 children between the age of 3 and 12 years old who were referred to Besat Hospital Hamadan, Iran, for tonsillectomy. Patients were randomly assigned to two groups. The intervention group (I) received intravenous acetaminophen plus 0.1 mg/kg ondansetron intravenously while the control group (C) received intravenous acetaminophen plus 2 ml of normal saline intravenously. Postoperative pain severity was assessed using the Children’s Hospital Eastern Ontario Pain Scale (CHEOPS). Frequency of nausea, vomiting, and need for analgesic was assessed and recorded four times, at recovery unit, after 6, 12, and 24 hours postsurgery. Data analysis was performed at 95% confidence level using the statistical package for social sciences (SPSS) software version 21. Results. The number of patients in groups I and C was 27 and 26 patients, respectively. Mean pain score in I and C groups was 4.48 and 2.88 at recovery unit, 2.74 and 2.04 after 6 hours, 1.67 and 0.81 after 12 hours, and 0.67 and 0.20 after 24 hours postsurgery, respectively. Frequency of nausea at recovery unit was 23.1% in I group and 0.0% in group C ( p = 0.010 ) while the mean number of analgesic requirements in I and C groups was 1.07 and 0.56 times, respectively ( p = 0.027 ). Conclusions. Intravenous administration of 0.1 mg/kg ondansetron reduces the analgesic action of intravenous acetaminophen after tonsillectomy in 3 to 12-year-old children.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

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The Effects of Ondansetron on the Analgesic Action of Intravenous Acetaminophen after Tonsillectomy in Children: A Triple‐Blind Randomized Controlled Trial

Nikooseresht

Nasrolahi

Hajian

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…However, studying on the involvement of 5-HT3 receptors yielded conflicting results in each animals and humans [38,39,[44][45][46][47][48][49][50].…”

Section: Different Molecular Targets Of Am404mentioning

confidence: 99%

Mechanism of Action, Kinetics and a Bioactive Metabolites AM404 of Paracetamol

Singh¹,

Kaur²

2020

JCMR

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“…However, investigations of the involvement of 5-HT 3 receptors yielded conflicting results in both animals [36,42,43,47,49,50] and humans [51][52][53][54]. Interestingly, some of these studies showed that tropisetron, a nonspecific 5-HT 3 receptor antagonist, blocked the analgesic effect of paracetamol.…”

Section: Involvement Of the Serotonergic Systemmentioning

confidence: 99%

Paracetamol: Update on its Analgesic Mechanism of Action

Mallet¹,

Eschalier²,

Daulhac³

2017

Pain Relief - From Analgesics to Alternative Therapies

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Paracetamol is the most widely used over-the-counter medication in the world. The mechanism of action of its analgesic effect was often considered as based on the mobilization of the cyclooxygenases and more recently on serotonergic pathways. A new metabolic pathway involving the generation of an active metabolite, AM404 (N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide), in the brain by the fatty acid amide hydrolase (FAAH) enzyme, was recently identified. This chapter describes experimental data that have shown the involvement of this metabolic pathway in the analgesic action of paracetamol and its relationship with the cyclooxygenase and serotonergic systems. It also explains how new targets and systems, such as the cannabinoid and vanilloid systems and the calcium channel receptor Cav3.2, play a role in the action of paracetamol. Finally, it suggests how research on the mechanism of the clinically relevant effects of this long-established analgesic could lead to new therapeutic pain strategies.

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Analgesic interaction between ondansetron and acetaminophen after tonsillectomy in children: The Paratron randomized, controlled trial

Cited by 22 publications

References 28 publications

The Effects of Ondansetron on the Analgesic Action of Intravenous Acetaminophen after Tonsillectomy in Children: A Triple‐Blind Randomized Controlled Trial

The Effects of Ondansetron on the Analgesic Action of Intravenous Acetaminophen after Tonsillectomy in Children: A Triple‐Blind Randomized Controlled Trial

Mechanism of Action, Kinetics and a Bioactive Metabolites AM404 of Paracetamol

Paracetamol: Update on its Analgesic Mechanism of Action

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