Analgesic efficacy of the cyclooxygenase-2-specific inhibitor rofecoxib in post-dental surgery pain: A randomized, controlled trial

Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

“…In studies of dental pain, doses of 12.5 to 500 mg of rofecoxib were more effective than placebo, and 50 mg of rofecoxib provided pain relief equal to 400 mg of ibuprofen but of longer duration. In a trial comparing rofecoxib with naproxen and placebo, 50 mg of rofecoxib, recognized as the maximum effective dose, gave an analgesic efficacy better than placebo and similar to 550 mg of naproxen (Morrison et al, 1999a). In another dental pain study, 50 mg of rofecoxib, 400 mg of ibuprofen, or 200 mg of celecoxib were more effective in relieving pain than placebo, and rofecoxib and ibuprofen were more effective than celecoxib (Malmstrom et al, 1999).…”

Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors

“…For instance, highly selective COX-2 inhibitors inhibit hyperalgesia in rats (Riendeau et al, 1997), and the process of sensing pain may 222 lead to the induction of COX-2 in spinal cord (Beiche et al, 1996). Importantly, selective inhibitors of COX-2, e.g., rofecoxib, have been shown to be analgesic in humans when used for postdental surgery pain (Morrison et al, 1999).…”

A simple pain model for the evaluation of analgesic effects of NSAIDs in healthy subjects

“…Electrically induced pain models were able to discriminate the effects of diclofenac from placebo [12] and to describe gender differences in response to ibuprofen [4]. Dental pain models inducing pain by removal of impacted or semi-impacted third molars did clearly demonstrate analgesic efficacy of NSAIDs compared with placebo [13][14][15]. In a laser-induced pain model [16] paracetamol showed significantly higher analgesic potency compared with placebo but lower compared with a combination of paracetamol and codeine.…”