Analgesic efficacy of aceclofenac after surgical extraction of impacted lower third molars

Lima, Paulo Valério Presser; Fontanella, Vania Regina Camargo

doi:10.1016/j.ijom.2005.09.001

Cited by 15 publications

(4 citation statements)

References 25 publications

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“…Four studies were examined for possible inclusion, but as none had a placebo control group, these were excluded (Yscla 1988; Movilia 1989; Chalini 2005; Presser Lima 2006). One was additionally not described as randomised (Yscla 1988).…”

Section: Resultsmentioning

confidence: 99%

Single dose oral aceclofenac for postoperative pain in adults

Moore

Derry

McQuay

2009

Cochrane Database of Systematic Reviews

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In the absence of evidence of efficacy for oral aceclofenac in acute postoperative pain (at least at 150 mg single dose), its use in this indication is not justified. Because trials clearly demonstrating analgesic efficacy in the most basic of acute pain studies are lacking, use in other indications should be evaluated carefully. Given the large number of effective drugs available in this and similar classes of analgesics, there is no urgent research agenda required to demonstrate the effective dose of aceclofenac in acute postoperative pain.

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Section: Resultsmentioning

confidence: 99%

Single dose oral aceclofenac for postoperative pain in adults

Moore

Derry

McQuay

2009

Cochrane Database of Systematic Reviews

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“…Appropriate post-instrumentation pain management before it peaks can positively influence patient satisfaction level and quality of life after endodontic treatment ( 28 , 29 ). Various premedication analgesics had been studied in mitigating postoperative pain in oral surgery ( 30 , 31 ) and root canal treatment ( 21 , 32 – 34 ). The role of Ibuprofen as a premedication analgesic had been proved in a recent systematic review and meta-analysis ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Oral Premedication with Aceclofenac (Immediate and Controlled release) on Post-instrumentation Pain in Root Canal Treatment – A Triple Blind Randomized Controlled Trial

Sundaramurthy¹

2023

Eur Endod J

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Objective Patients with moderate to severe preoperative pain have a high incidence of postoperative pain. The objective of this trial was to evaluate the efficiency of oral premedication with Aceclofenac (immediate release and controlled release) in the management of post-instrumentation pain in root canal treatment, in patients with moderate to severe preoperative pain. Methods Three-arm parallel, triple blinded randomized controlled trial was planned. Patients with moderate to severe endodontic pain, requiring primary endodontic treatment were enrolled. Aceclofenac 100mg- immediate release (Aceclofenac-IR), Aceclofenac 200mg- controlled release (Aceclofenac-CR), and Ibuprofen 400mg were compared. The tablets were given one hour before the root canal treatment. Postoperatively, patients rated their pain at various time points. The duration of pain relief (primary outcome), the intensity of post-instrumentation pain, and the need for additional medicine were calculated. Statistical analysis was done using Kruskal-Wallis followed by Dunn post-hoc, Chi-square tests, and Binominal logistic regression. Results Aceclofenac-CR had a statistically significant longest duration of pain relief when compared to Ibuprofen (p=0.037) and Aceclofenac-IR (p=0.026). The intensity of post-instrumentation pain was lowest in Aceclofenac-CR, followed by Aceclofenac-IR and Ibuprofen. Additional medicine was required for only 8% of patients in Aceclofenac-CR group; whereas for 32% in each of Aceclofenac-IR and Ibuprofen groups. The odds of taking additional medicine were reduced to 0.16 in Aceclofenac-CR; increased to 1.05 with age. Conclusion Aceclofenac-CR had the longest duration of pain relief compared to Aceclofenac-IR and Ibuprofen.

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“…Excluded studies-Four studies were examined for possible inclusion, but as none had a placebo control group, these were excluded (Yscla 1988;Movilia 1989;Chalini 2005;Presser Lima 2006). One was additionally not described as randomised (Yscla 1988).…”

Section: Description Of Studiesmentioning

confidence: 99%

Single dose oral aceclofenac for postoperative pain in adults

Moore¹,

Derry²,

McQuay³

2009

Cochrane Database of Systematic Reviews

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Background-Aceclofenac is the prodrug of the non-steroidal anti-inflammatory drug (NSAID) diclofenac, widely used to treat acute and chronic pain. There are no known systematic reviews of its analgesic efficacy in acute postoperative pain. This review sought to evaluate the efficacy and safety of oral aceclofenac in acute postoperative pain, using clinical studies of patients with established pain, and with outcomes measured primarily over 6 hours using standard methods. This type of study has been used for many decades to establish that drugs have analgesic properties.

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Analgesic efficacy of aceclofenac after surgical extraction of impacted lower third molars

Cited by 15 publications

References 25 publications

Single dose oral aceclofenac for postoperative pain in adults

Single dose oral aceclofenac for postoperative pain in adults

Efficacy of Oral Premedication with Aceclofenac (Immediate and Controlled release) on Post-instrumentation Pain in Root Canal Treatment – A Triple Blind Randomized Controlled Trial

Single dose oral aceclofenac for postoperative pain in adults

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