Analgesic effects of tramadol hydrochloride administered via caudal epidural injection in healthy adult cattle

Baniadam, Ali; Afshar, F Saberi; Ahmadian, Fakhredin

doi:10.2460/ajvr.71.7.720

Cited by 10 publications

(14 citation statements)

References 15 publications

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“…Intravenous medication may cause safety problems, such as respiration depression (Yaster and Nichols, 2001;Mantadakis et al, 2009;Batra et al, 2010), while local anesthesia in lumbar punctures may not work due to patients' crying (Committee on Drugs and American Academy of Pediatrics, 2002;Draisci et al, 2009;Baniadam et al, 2010;Shadangi et al, 2011). Propofol is an intravenous anesthetic commonly used clinically, which is quickly effective and easily controlled.…”

Section: Discussionmentioning

confidence: 99%

Rapid sedation induced by fentanyl combined with propofol via an intrathecal chemotherapy injection for leukemia in children

et al. 2015

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ABSTRACT. This study explored the sedative and analgesic effects of fentanyl combined with propofol via an intrathecal chemotherapy injection for acute leukemia (acute lymphocytic leukemia or acute myelocytic leukemia) among children, to relieve pain and difficulty during intrathecal injection, improve treatment compliance, increase the success rate of single puncture, and reduce procedure failure, with the aim of developing a painless procedure for children with acute leukemia. Fifty person-times received fentanyl combined with propofol via an intrathecal chemotherapy injection among the hospitalized children with leukemia. The patients' cooperation with the procedure, response to the medication, dosages of fentanyl and propofol, reaction to the procedures, wake-up time, and changes in oxygen saturation (SpO 2 ), heart rate (HR), respiration, and blood pressure (BP) before, during, and after the procedures were observed. The doctors who performed the procedures assessed the quality of sedation and analgesia. In the treatment group, the patients were quiet during the lumbar puncture and intrathecal injection, showing good sedation and analgesia. HR and respiration decreased slightly. There were no changes in SpO 2 and BP. No obvious respiratory depression occurred with proper dosages. Only a few patients showed stertorous respiration, which stopped soon after the procedures. In the control group, the patients were agitated, crying, and not cooperative before and during the procedures, which made the procedures very difficult. During intrathecal injection, pain obviously reduced and the success rate of single lumbar puncture increased. It is safe and effective to apply fentanyl combined with propofol for sedation and analgesia.

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Section: Discussionmentioning

confidence: 99%

Rapid sedation induced by fentanyl combined with propofol via an intrathecal chemotherapy injection for leukemia in children

et al. 2015

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“…Caudal epidural tramadol administration has been performed in different species such as horses (Natalini & Robinson, 2002), cattle (Baniadam et al, 2010;Bigham et al, 2010), sheep (Habibian et al, 2011), goats (Dehkordi et al, 2012), cats (Castro et al, 2009) and dogs (Guedes et al, 2005;Natalini et al, 2007). However, to the authors' knowledge, this is the first study to investigate the analgesic effect of epidural administration of tramadol (monotherapy) in camels.…”

Section: Discussionmentioning

confidence: 99%

“…In a study conducted by Elghazali et al (2008), no drug-associated adverse effect was observed following intravenous and intramuscular tramadol in camels. According to the studies performed in cattle (Baniadam et al, 2010), horses (Natalini & Robinson, 2002), donkeys (Faleiros et al, 2004) and dogs (Guedes et al, 2005), epidural tramadol had no effect on HR, RR and RT. However, based on the results of the present study, there was an increase in HR, RR and RT in the first 15 to 30 min of the experiment and soon after that, the increasing trend stopped.…”

Section: Variablementioning

confidence: 99%

“…When compared with ketamine and lidocaine, caudal epidural tramadol resulted in longer duration of analgesia in camels; however, onset of analgesia was slower. In a similar study performed to evaluate the analgesic effects of caudal epidural tramadol (dose: 2 mg/kg) in cattle, Baniadam et al (2010) reported the mean onset of 6-12 min and a mean duration of 30 min for perineal analgesia. So the same dose of tramadol (2 mg/kg) produced faster but shorter duration of antinociception in cattle, in comparison to our results in camels.…”

Section: Variablementioning

confidence: 99%

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Analgesic and sedative effects of caudal epidural tramadol in dromedary camels

Azari¹,

Seyyedin²,

Molaei³

et al. 2019

BJVM

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This study aimed to investigate the analgesic efficacy of caudal epidural administration of tramadol in dromedary camels (Camelus dromedarius). A total of 10 dromedary camels of both sexes were selected and randomly assigned to one of two groups to receive epidurally either 1 mg/kg or 2 mg/kg of tramadol hydrochloride. The injections were made into the epidural space at first intercoccygeal junction. Using a pinprick method, analgesia was tested. Duration and onset of complete perineal analgesia were determined. Ataxia and sedation were also assessed and recorded. Clinical parameters including heart rate, respiratory rate and rectal temperature were measured. The lower dose (1 mg/kg) of tramadol induced analgesia only in the tail but the higher dose produced complete antinociception in the tail, anus and perineum. Analgesia of the hind limbs was not achieved after either doses of tramadol. The mean times to onset and duration of complete analgesia in camels receiving epidural tramadol at a dose of 2 mg/kg were 22±2.55 min and 65±8.66 min, respectively. Various degrees of ataxia occurred in all camels. Mild to deep sedation was observed following both doses. Mean heart rate, respiratory rate, and rectal temperature tended to increase for the first 15 or 30 min after injection. Based on the results of this study, analgesic effects of caudal epidural tramadol were dose dependent. Epidural tramadol at a dose of 2 mg/kg would provide suitable postoperative analgesia for various manipulations in the tail, anus and perineum in standing dromedary camels.

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“…A utilização de analgésicos opioides, como alternativa para o manejo de dor em bovinos, ocorre, principalmente, através da via de administração epidural (5) . Contudo, a aplicação sistêmica destes fármacos é limitada a poucos princípios ativos como a morfina, meperidina, buprenorfina e butorfanol (6) .…”

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Pedometria Aplicada a Estudo Comparativo Entre Morfina E Tramadol Em Bovinos

et al. 2019

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Resumo A analgesia com opioides é limitada ou indefinida em ruminantes. Neste trabalho, objetivou-se a realização de um estudo comparativo entre dois analgésicos opioides: a morfina e o tramadol, com base nas avaliações clínica e pedométrica de animais submetidos a artrite e sinovite experimental transitórias, desenvolvidas na articulação interfalângica distal, após administração intra-articular de anfotericina B. Utilizou-se seis animais, em dois tratamentos distintos, com morfina, na dose de 0,5 mg/kg e 20 dias depois com tramadol, na dose de 1,8 mg/kg, ambos via intramuscular. Os animais foram avaliados em intervalos de três horas, num total de 27 horas, observando-se parâmetros fisiológicos, deambulação e atividade pedométrica. Claudicação e alterações pedométricas foram observadas para ambos os fármacos. Por meio das variáveis da atividade pedométrica, observou-se um padrão de inquietação compatível com nocicepção podal, não havendo a interferência dos fármacos sobre a claudicação. Concluiu-se que a morfina e o tramadol, nas doses testadas, foram incapazes de interferir na atenuação do grau de claudicação no momento de máxima estimulação dolorosa, frente ao modelo experimental de dor ortopédica.

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Analgesic effects of tramadol hydrochloride administered via caudal epidural injection in healthy adult cattle

Abstract: Caudal epidural tramadol administration induced analgesia with slight to mild sedation and ataxia in cows. Analgesia in affected regions after administration of 2 or 3 mg of tramadol/kg was considered sufficient to allow common surgical procedures to be performed in standing cattle.

Cited by 10 publications

References 15 publications

Rapid sedation induced by fentanyl combined with propofol via an intrathecal chemotherapy injection for leukemia in children

Rapid sedation induced by fentanyl combined with propofol via an intrathecal chemotherapy injection for leukemia in children

Analgesic and sedative effects of caudal epidural tramadol in dromedary camels

Pedometria Aplicada a Estudo Comparativo Entre Morfina E Tramadol Em Bovinos

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