Analgesic effects of medicinal plants and phytochemicals on chemotherapy‐induced neuropathic pain through glial modulation

Lee, Ji Hwan; Kim, Nari; Park, Sang Won; Kim, Sun Kwang

doi:10.1002/prp2.819

Cited by 7 publications

(8 citation statements)

References 87 publications

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“…The genus Trichosanthes is mainly distributed in eastern and southern Asia in warm and moist habitats [47,55]. As a medicinal use, it has been known that different parts of the plant, such as the fruit, root, and seed, have different efficacies [31]. In this study, the root tuber of Tk was used, which has been reported to have a treatment effect against diabetes [56].…”

Section: Discussionmentioning

confidence: 99%

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Analgesic Effect of SH003 and Trichosanthes kirilowii Maximowicz in Paclitaxel-Induced Neuropathic Pain in Mice

Lee

Kim

et al. 2022

CIMB

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Pacliatxel is a taxol-based chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use. Although several drugs are prescribed to attenuate neuropathies, no optimal treatment is available. Thus, in our study, we analyzed whether SH003 and its sub-components could alleviate paclitaxel-induced neuropathic pain. Multiple paclitaxel injections (cumulative dose 8 mg/kg, i.p.) induced cold and mechanical allodynia from day 10 to day 21 after the first injection in mice. Oral administration of SH003, an herbal mixture extract of Astragalus membranaceus, Angelica gigas, and Trichosantheskirilowii Maximowicz (Tk), dose-dependently attenuated both allodynia. However, when administered separately only Tk decreased both allodynia. The effect of Tk was shown to be mediated by the spinal noradrenergic system as intrathecal pretreatment with α1- and α2-adrenergic-receptor antagonists (prazosin and idazoxan), but not 5-HT1/2, and 5-HT3-receptor antagonists (methysergide and MDL-72222) blocked the effect of Tk. The spinal noradrenaline levels were also upregulated. Among the phytochemicals of Tk, cucurbitacin D was shown to play a major role, as 0.025 mg/kg (i.p.) of cucurbitacin D alleviated allodynia similar to 500 mg/kg of SH003. These results suggest that Tk should be considered when treating paclitaxel-induced neuropathic pain.

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Section: Discussionmentioning

confidence: 99%

“…We have demonstrated the analgesic effect of bee venom, morphine, and herbal medicines [22,[26][27][28][29]. Among them, we focused on various herbal medicines, since herbal medicines are mostly known to be relatively safe and to induce only a low occurrence of side effects compared to other chemically modified drugs [30,31].…”

Section: Introductionmentioning

confidence: 99%

Analgesic Effect of SH003 and Trichosanthes kirilowii Maximowicz in Paclitaxel-Induced Neuropathic Pain in Mice

Lee

Kim

et al. 2022

CIMB

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“…Another mechanism involves glial activation [ 21 , 39 , 40 ]. For example, the myelin sheath can be damaged by chemotherapeutic agents.…”

Section: Peripheral and Spinal Mechanisms Of The Cipnmentioning

confidence: 99%

Therapeutics for Chemotherapy-Induced Peripheral Neuropathy: Approaches with Natural Compounds from Traditional Eastern Medicine

Chung

Kim

2022

Pharmaceutics

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Chemotherapy-induced peripheral neuropathy (CIPN) often develops in patients with cancer treated with commonly used anti-cancer drugs. The symptoms of CIPN can occur acutely during chemotherapy or emerge after cessation, and often accompany long-lasting intractable pain. This adverse side effect not only affects the quality of life but also limits the use of chemotherapy, leading to a reduction in the survival rate of patients with cancer. Currently, effective treatments for CIPN are limited, and various interventions are being applied by clinicians and patients because of the unmet clinical need. Potential approaches to ameliorate CIPN include traditional Eastern medicine-based methods. Medicinal substances from traditional Eastern medicine have well-established analgesic effects and are generally safe. Furthermore, many substances can also improve other comorbid symptoms in patients. This article aims to provide information regarding traditional Eastern medicine-based plant extracts and natural compounds for CIPN. In this regard, we briefly summarized the development, mechanisms, and changes in the nervous system related to CIPN, and reviewed the substances of traditional Eastern medicine that have been exploited to treat CIPN in preclinical and clinical settings.

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“…In fact, although being considered as an neuropathic pain, current pharmacological treatments for this condition (tricyclic antidepressants, anticonvulsants, etc.) are slightly effective in CIPN or have undesirable reactions (Hou et al, 2018), such as dizziness, nausea, somnolence and vomiting (Lee et al, 2021).…”

Section: Graphical Abstract 1 Introductionmentioning

confidence: 99%

“…In this sense, the development of neuropathies is the most recurrent cause for alteration of chemotherapy regimens, leading to a decrease in dose and frequency or choice of a different therapeutic agent, leading to impairments to the treatment and a lower quality of life ( Lee et al, 2021 ). Unfortunately, there are no sufficient options available for the CIPN treatment ( Colvin, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive effect of plant-based natural products in chemotherapy-induced peripheral neuropathies: A systematic review

et al. 2022

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Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most prevalent and difficult-to-treat symptoms in cancer patients. For this reason, the explore for unused helpful choices able of filling these impediments is essential. Natural products from plants stand out as a valuable source of therapeutic agents, being options for the treatment of this growing public health problem. Therefore, the objective of this study was to report the effects of natural products from plants and the mechanisms of action involved in the reduction of neuropathy caused by chemotherapy. The search was performed in PubMed, Scopus and Web of Science in March/2021. Two reviewers independently selected the articles and extracted data on characteristics, methods, study results and methodological quality (SYRCLE). Twenty-two studies were selected, describing the potential effect of 22 different phytochemicals in the treatment of CIPN, with emphasis on terpenes, flavonoids and alkaloids. The effect of these compounds was demonstrated in different experimental protocols, with several action targets being proposed, such as modulation of inflammatory mediators and reduction of oxidative stress. The studies demonstrated a predominance of the risk of uncertain bias for randomization, baseline characteristics and concealment of the experimental groups. Our findings suggest a potential antinociceptive effect of natural products from plants on CIPN, probably acting in several places of action, being strategic for the development of new therapeutic options for this multifactorial condition.

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Analgesic effects of medicinal plants and phytochemicals on chemotherapy‐induced neuropathic pain through glial modulation

Cited by 7 publications

References 87 publications

Analgesic Effect of SH003 and Trichosanthes kirilowii Maximowicz in Paclitaxel-Induced Neuropathic Pain in Mice

Analgesic Effect of SH003 and Trichosanthes kirilowii Maximowicz in Paclitaxel-Induced Neuropathic Pain in Mice

Therapeutics for Chemotherapy-Induced Peripheral Neuropathy: Approaches with Natural Compounds from Traditional Eastern Medicine

Antinociceptive effect of plant-based natural products in chemotherapy-induced peripheral neuropathies: A systematic review

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