Analgesic Effects of Gabapentin after Spinal Surgery

Turan, Alparslan; Karamanlıoğlu, Beyhan; Memiş, Dilek; Hamamcıoğlu, Mustafa Kemal; Tükenmez, Barış; Pamukçu, Zafer; Kurt, İmran

doi:10.1097/00000542-200404000-00025

Cited by 224 publications

(137 citation statements)

References 19 publications

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“…The surgeries included abdominal hysterectomy, 21,22 radical mastectomy or lumpectomy, 19,23 vaginal hysterectomy, 17 laparoscopic cholecystectomy 18 and lumbar discectomy or spinal fusion. 24,25 Due to the nature of the surgeries, four of the trials evaluated female patients only. One study did not evaluate side effects.…”

Section: Resultsmentioning

confidence: 99%

“…17,18,22,24,25 This difference was most pronounced at 12-18 hr postoperatively. While the study by Fassoulaki et al, 19 which measured pain at rest as well as pain on mobilization, found no significant difference in visual analogue scale scores at rest during the first 24 hr postoperatively, it did find significantly lower resting pain scores in the gabapentin group by the third postoperative day.…”

Section: Pain Scoresmentioning

confidence: 92%

See 1 more Smart Citation

Preoperative gabapentin for postoperative analgesia: a meta-analysis

Seib¹,

Paul

2006

Can J Anesth/J Can Anesth

191

103

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Purpose: Gabapentin's role in the treatment of chronic neuropathic pain is well known. What is less well established is its role for managing postoperative pain. In order to clarify whether gabapentin's utility in acute pain control is more than just theoretical, we conducted a meta-analysis of all randomized trials that addressed gabapentin's role in acute postoperative pain control. We specifically addressed whether gabapentin reduces pain scores, analgesia consumption, and/or analgesia-related side effects in the first 24 hr following surgery. Source:We identified eight placebo-controlled, randomized controlled trials and conducted a meta-analysis using the primary outcomes of pain scores, total analgesia consumption, and side effects over a 24-hr period. Principle findings:Patients who received gabapentin preoperatively reported significantly lower pain scores (-11.9 at rest and -11.0 with movement on a 100-point visual analogue scale) and opioid consumption (-14.7 mg of morphine in 24 hr) with no difference in the incidence of side effects. Conclusion:Although gabapentin given preoperatively decreases pain scores and analgesic consumption in the first 24 hr after surgery, the clinical significance of this finding has yet to be determined. This meta-analysis could not demonstrate a significant reduction in the incidence of side effects. Due to the small numbers enrolled in the studies, larger randomized control trials are warranted. Objectif : Le rôle de la gabapentine dans le traitement de la douleur neuropathique chronique est bien connu. Ce qui l'est moins, c'est son rôle dans le traitement de la douleur postopératoire. Pour le vérifier, nous avons fait une méta-analyse de toutes les études randomisées qui ont abordé le rôle de la gabapentine dans le contrôle de la douleur postopératoire aiguë. Nous avons surtout cherché si la gabapentine réduit les scores de douleur, la consommation d'analgésique et/ou les effets secondaires reliés à l'analgésie des 24 premières heures postopératoires. Source : Nous avons repéré huit études randomisées, contrôlées contre placebo et mené une méta-analyse en utilisant les principaux paramètres des scores de douleur, consommation totale d'analgésique et effets secondaires pendant 24 h.Constatations principales : Les patients qui ont reçu de la gabapentine préopératoire ont présenté des scores de douleur (-11,9 au repos et -11,0

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Section: Resultsmentioning

confidence: 99%

Section: Pain Scoresmentioning

confidence: 92%

Preoperative gabapentin for postoperative analgesia: a meta-analysis

Seib¹,

Paul

2006

Can J Anesth/J Can Anesth

191

103

View full text Add to dashboard Cite

show abstract

“…Pre-procedural gabapentin treatment is also effective in treating pain during spinal, otolaryngological, gynecological, and endoscopic procedures, and burn wound debridement [9,15,16,[22][23][24][25]. Some studies suggest that it reduces the stress response that may occur during laryngoscopy and tracheal intubation [26].…”

Section: Discussionmentioning

confidence: 99%

Perioperative gabapentin as a component of multimodal analgesia for postoperative pain after total knee arthroplasty

Khuvtsagaan

Lundeg

2017

Anesth Pain Med

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“…7 As gabapentin enhances the analgesic effects of morphine in healthy volunteers and the combination produces better analgesia in comparison with morphine alone, 8 the drug may exert a selective effect on the nociceptive process involved in central neuronal sensitization, and is the rationale for its use in the treatment of acute postoperative pain. 9 The antihyperalgesic effects of gabapentin result from an action at the α 2 -Δ subunits of voltage dependent Ca ++ channels which are up-regulated in the dorsal root ganglia and spinal cord after peripheral injury. 9,10 Gabapentin may also produce antihyperalgesia by decreasing glutaminergic transmission in the spinal cord.…”

Section: Table III Side Effects In Different Groupsmentioning

confidence: 99%

“…9 The antihyperalgesic effects of gabapentin result from an action at the α 2 -Δ subunits of voltage dependent Ca ++ channels which are up-regulated in the dorsal root ganglia and spinal cord after peripheral injury. 9,10 Gabapentin may also produce antihyperalgesia by decreasing glutaminergic transmission in the spinal cord. 11 In addition, it may inhibit central neuronal sensitization and hyperalgesia through an action at voltage dependent Ca ++ channels resulting in a direct postsynaptic or pre-synaptic inhibition of Ca ++ influx that decreases excitatory amino acid neurotransmission.…”

Section: Table III Side Effects In Different Groupsmentioning

confidence: 99%