Analgesic effects of different concentrations of ropivacaine in transversalis fascia plane block during laparotomy

Tian, Ye; Zhan, Yong; Ke, Liu; Bu, Shaojin; Tian, Yalin; Xiong, Chunyan; Shen, Jintao

doi:10.1186/s12871-022-01595-8

Cited by 7 publications

(3 citation statements)

References 25 publications

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“…Lee et al [ 12 ] also compared low-concentration ropivacaine and high-concentration ropivacaine in transverse abdominis plain blocks in pediatric open inguinal hernia repair. Han et al [ 13 ] and Tian et al [ 14 ] reported the analgesic effects of different ropivacaine concentrations in patients undergoing hip replacement and laparotomy. Previous studies reported that 0.75% ropivacaine was within the safety limits.…”

Section: Discussionmentioning

confidence: 99%

Safety of pre-incisional low-dose ropivacaine infiltration in bilateral axillo-breast approach thyroidectomy: a retrospective study.

Cho¹,

Jeong²,

Kim³

et al. 2022

Videosurgery and Other Miniinvasive Techniques

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Introduction: Ropivacaine is widely used as a local analgesic, but it has toxicity that is related to the concentration, and highly concentrated ropivacaine can induce motor nerve blockage. Aim: To investigate the safety of low-concentration pre-incisional ropivacaine injection for postoperative pain control and compare postoperative adverse events between a low-concentration ropivacaine injection group and a high-concentration ropivacaine injection group. Material and methods: Patients who underwent thyroidectomy via the bilateral axillo-breast approach (BABA) between June 2017 and October 2021 performed by a single surgeon at Samsung Medical Center were retrospectively identified. These outcomes were compared between the two groups after 1 : 1 propensity score matching. Results: From a total of 633 patients, 620 patients were selected. There were 527 in the low-concentration ropivacaine group and 93 in the high-concentration ropivacaine group. After propensity score matching, two comparable groups with 93 patients in each were obtained. The incidence of ropivacaine-related adverse events was similar between the two groups (p = 0.186) but the occurrence of postoperative bradycardia (p = 0.048) was lower in the low-concentration ropivacaine group than in the high-concentration ropivacaine group. Other outcomes such as postoperative pain scores (p = 0.363), postoperative nausea and vomiting (p > 0.999), and postoperative opioid consumption (p = 0.699) were similar between the two groups. Conclusions: Pre-incisional low-concentration ropivacaine injection was effective for postoperative pain control and can be safely used in BABA thyroidectomy.

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Section: Discussionmentioning

confidence: 99%

Safety of pre-incisional low-dose ropivacaine infiltration in bilateral axillo-breast approach thyroidectomy: a retrospective study.

Cho¹,

Jeong²,

Kim³

et al. 2022

Videosurgery and Other Miniinvasive Techniques

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“…Some studies have pointed out that low-concentration ropivacaine will not cause complete blockade of nerves because it will not significantly affect the patient's respiratory function, which improves the safety of treatment [ 15 ]. Tian et al [ 16 ] used 0.4%, 0.5%, and 0.6% of ropivacaine for anesthesia, and found that the total adverse reaction rate of 0.6% ropivacaine was significantly higher than that of the low-concentration group. The results are consistent with this study.…”

Section: Discussionmentioning

confidence: 99%

Effects of Different Concentrations of Ropivacaine Lumbar Plexus-Sciatic Nerve Block on Recovery from Anesthesia, Postoperative Pain and Cognitive Function in Elderly Patients with Femoral Neck Fracture

Cheng

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the effects of lumbar plexus-sciatic nerve block with different concentrations of ropivacaine on recovery from anesthesia, postoperative pain, and cognitive function in elderly patients with femoral neck fracture. Method. A total of 110 elderly patients with femoral neck fractures who were treated in our hospital from January 2020 to January 2022 were selected as the research objects. According to the concentration of ropivacaine, they were divided into low-, medium-, and high-concentration groups (concentrations of ropivacaine were 0.15%, 0.25%, and 0.40%, respectively), with 36, 37, and 37 cases, respectively. Extubation time, anesthesia recovery time, and hospitalization time were recorded. Cognitive symptoms were assessed by the spatial cognitive ability, working memory ability, simple computing ability, and picture recognition ability test. The pain degree of patients was assessed by visual analogue scale (VAS). The occurrence of adverse reactions in patients was recorded. Result. There was no significant difference in extubation time, anesthesia recovery time, and hospitalization time among the three groups ( P > 0.05 ). The PCA time of the patients in the high-concentration group was significantly longer than that in the low- and medium-concentration groups. The dosage of sufentanil within 24 hours and total sufentanil in the high-concentration group were significantly lower than those in the low- and medium-concentration groups, and the dosage of sufentanil within 24 hours and total sufentanil in the medium-concentration group was significantly less than that in the low-concentration group ( P < 0.05 ). The cognitive function score for each entry of the three groups 1 d after surgery was lower than that before surgery ( P < 0.05 ); On the 1 day after operation, the cognitive function score for each entry of the patients in the low-concentration group was significantly higher than that in the middle- and high-concentration groups, and the cognitive function score for each entry in the middle-concentration group was significantly higher than that in the high-concentration group ( P < 0.05 ). There was no significant difference in VAS scores between the three groups at 2 h and 8 h after surgery ( P > 0.05 ); 16 h and 24 h after operation, the VAS score of patients in the high-concentration group was significantly lower than that in the low- and medium-concentration groups, and the VAS score in the medium-concentration group was significantly lower than that in the low-concentration ropivacaine group ( P < 0.05 ). The incidence of adverse reactions in the high-concentration ropivacaine group was significantly higher than that in the low- and medium-concentration groups ( P < 0.05 ). Conclusion. The middle concentration of ropivacaine has good analgesic and nerve block effects and has less influence on cognitive function and less adverse reactions in elderly patients.

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“…[4][5][6] Currently, ropivacaine is the most commonly used local anaesthetic for PNB due to its lower toxicity in the central nervous system and heart. 7 8 The concentrations of ropivacaine used for PNB are various, and the efficacy and safety of different concentrations of ropivacaine have been compared in several RCTs, [9][10][11][12][13][14] but the results were inconsistent. Therefore, it is meaningful to perform a systematic review and meta-analysis to determine the optimal concentration of ropivacaine for PNB, which may provide longer analgesia without increasing the incidence of adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Optimal concentration of ropivacaine for peripheral nerve blocks in adult patients: a protocol for systematic review and meta-analysis

Li,

Pan,

et al. 2023

BMJ Open

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IntroductionRopivacaine is the most widely used local anaesthetic for peripheral nerve blocks (PNBs). The effects of various concentrations of ropivacaine in PNB have been investigated and compared by many randomised controlled trials (RCTs). This protocol aims to identify the optimal concentration of ropivacaine for PNB in adult patients.Methods and analysisPubMed, EMBASE, the Cochrane library and Web of Science will be searched from their inception to 10 July 2023. RCTs that compare the analgesic effects of different concentrations of ropivacaine for PNB will be included. Retrospective studies, meta-analyses, reviews, case reports, letters, conference abstracts and paediatric studies will be excluded. The duration of analgesia will be named as the primary outcome. Secondary outcomes will include the onset time of motor and sensory blockade, postoperative pain scores, analgesic requirements over 24 hours and the incidence of adverse effects. The study selection, data extraction and quality assessment will be performed by two independent reviewers. Data processing and analysis will be performed by RevMan 5.4. The quality of the evidence will be assessed by the Grading of Recommendations Assessment, Development and Evaluation approach.Ethics and disseminationEthical approval is not applicable. The results of this study will be submitted to peer-reviewed journals.PROSPERO registration numberCRD42023406362.

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Analgesic effects of different concentrations of ropivacaine in transversalis fascia plane block during laparotomy

Cited by 7 publications

References 25 publications

Safety of pre-incisional low-dose ropivacaine infiltration in bilateral axillo-breast approach thyroidectomy: a retrospective study.

Safety of pre-incisional low-dose ropivacaine infiltration in bilateral axillo-breast approach thyroidectomy: a retrospective study.

Effects of Different Concentrations of Ropivacaine Lumbar Plexus-Sciatic Nerve Block on Recovery from Anesthesia, Postoperative Pain and Cognitive Function in Elderly Patients with Femoral Neck Fracture

Optimal concentration of ropivacaine for peripheral nerve blocks in adult patients: a protocol for systematic review and meta-analysis

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