Analgesic effects of Chinese Tuina massage in a rat model of pain

Jiang, Shichao; Hao, Zhang; Fang, Min; Zhang, Yu-Qui; Lü, Nonghua; Zhu, Qi; Cheng, Yong; Ai, Jian; Zhou, Nan; Li, Jianhua; Fang, Lei; Yao, Fei

doi:10.3892/etm.2016.3055

Cited by 19 publications

(16 citation statements)

References 19 publications

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“…It can relieve the pathological fatigue state of the muscles, harmonize the coordinated balance function of the flexors and extensors, and finally restore a physiological balance of muscles and bones [41]. In previous studies, a rat model was established to demonstrate that Tuina could reduce pain sensitivity and peripheral nociceptive peripheral Cfiber activity in rats and could accelerate the repair peripheral nerve injury [42,43].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Tuina in patients with chronic low back pain: study protocol for a randomized controlled trial

Zhang

Kong

Zhu

et al. 2020

Trials

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Background: Low back pain is a common reason for medical care and carries a heavy social burden. The efficacy of Tuina or health care education for low back pain has been evaluated in previous systematic reviews. However, there is no evidence to support the superiority of one form of treatment over another. The aim of this study is to compare the efficacy of Tuina with health care education in the management of low back pain.Methods/design: This study is a randomized controlled trial with parallel-group design including two groups: a Tuina group and a health care education group. A total of 160 eligible participants will be randomly assigned to the groups in a 1:1 ratio. The interventions of both groups will last for 20 min and be carried out twice each week for a period of 12 weeks. The primary outcome is the Oswestry Disability Index. The secondary outcomes include a visual analogue scale and the 36-item Short Form Health Survey. They will be assessed at baseline, at the end of the intervention every month, and during 6 months and 9 months of follow-up by repeated measures analysis of variance. The significance level is 5%. The safety of Tuina and health care education will be evaluated after each treatment session. This study will focus on the value of Tuina and health care education for low back pain and will highlight any differences in the efficacy of the treatments.Discussion: This study will evaluate the efficacy and safety of Tuina intervention for low back pain, which could provide reliable evidence for clinical decision making for patients with low back pain.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Tuina in patients with chronic low back pain: study protocol for a randomized controlled trial

Zhang

Kong

Zhu

et al. 2020

Trials

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“…Since some of the miRNAs associated with pain initiation and maintenance have also been classified as mechanomiRs [ 46 ], it seems logical to think that MT might have an impact on their expression profiles. Perhaps it is through the regulation of mechanomiR levels that MT exerts at least some of the attributed analgesic effects [ 98 ].…”

Section: Molecular Determinants Of Mt: Lessons From Animal Models mentioning

confidence: 99%

Unraveling the Molecular Determinants of Manual Therapy: An Approach to Integrative Therapeutics for the Treatment of Fibromyalgia and Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Espejo

García-Escudero

Oltra

2018

IJMS

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Application of protocols without parameter standardization and appropriate controls has led manual therapy (MT) and other physiotherapy-based approaches to controversial outcomes. Thus, there is an urgency to carefully define standard protocols that elevate physiotherapy treatments to rigorous scientific demands. One way in which this can be achieved is by studying gene expression and physiological changes that associate to particular, parameter-controlled, treatments in animal models, and translating this knowledge to properly designed, objective, quantitatively-monitored clinical trials (CTs). Here, we propose a molecular physiotherapy approach (MPTA) requiring multidisciplinary teams, to uncover the scientific reasons behind the numerous reports that historically attribute health benefits to MT-treatments. The review focuses on the identification of MT-induced physiological and molecular responses that could be used for the treatment of fibromyalgia (FM) and chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). The systemic effects associated to mechanical-load responses are considered of particular relevance, as they suggest that defined, low-pain anatomic areas can be selected for MT treatment and yet yield overall benefits, an aspect that might result in it being essential to treat FM. Additionally, MT can provide muscle conditioning to sedentary patients without demanding strenuous physical effort, which is particularly detrimental for CFS/ME patients, placing MT as a real option for integrative medicine programs to improve FM and CFS/ME.

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“…Perhaps it is through regulation of mechanomiR levels that MT exerts at least some of the attributed analgesic effects [98].…”

Section: Mt Impact On the Nervous System And On Pain Reliefmentioning

confidence: 99%

Unraveling molecular determinants of manual therapy: an approach to integrative therapeutics for the treatment of fibromyalgia and CFS/ME

Espejo¹,

García-Escudero²,

Oltra³

2018

Preprint

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Abstract:Application of protocols without parameter standardization and rigorous controls has led manual therapy (MT) and other physiotherapy approaches to controversial outcomes. Thus, there is an urgency to carefully define standard protocols that elevate physiotherapy treatments to rigorous scientific demands. One way this can be achieved is by studying gene expression and additional physiological changes that associate to particular, parameter-controlled, treatments in animal models and translating this knowledge to properly design objective, quantitatively-monitored clinical trials. Here, we propose a Molecular Physiotherapy Approach (MPTA), requiring multidisciplinary teams, to uncover the scientific reasons behind the numerous reports of MT that historically attribute benefits to these treatments. The review focuses in the identification of MT-induced physiological and molecular responses that could be used for the treatment of fibromyalgia (FM) and CFS/ME. The systemic effect associated to mechanical-load responses is considered of particular relevance as it suggests that defined, low-pain areas could be selected for treatments with overall benefits, an aspect that might result essential to treat FM. Additionally, MT can provide muscle conditioning to sedentary patients without demanding strenuous physical effort, detrimental for CFS/ME patients, placing MT as a real option for integrative medicine programs to treat FM and CFS/ME.

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Analgesic effects of Chinese Tuina massage in a rat model of pain

Cited by 19 publications

References 19 publications

Efficacy of Tuina in patients with chronic low back pain: study protocol for a randomized controlled trial

Efficacy of Tuina in patients with chronic low back pain: study protocol for a randomized controlled trial

Unraveling the Molecular Determinants of Manual Therapy: An Approach to Integrative Therapeutics for the Treatment of Fibromyalgia and Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Unraveling molecular determinants of manual therapy: an approach to integrative therapeutics for the treatment of fibromyalgia and CFS/ME

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