Analgesic effectiveness of the narcotic agonist‐antagonists.

Houde, Raymond W.

doi:10.1111/j.1365-2125.1979.tb04704.x

Cited by 121 publications

(20 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequently, studies for the development of potent analgesics with low or no physical dependence-producing po tential have been intensively pursued in animals (2-4) and man (5,6). Furthermore, methods to produce potent analgesic effects with low doses of opioid analgesics in combination with other drugs have also been investigated.…”

mentioning

confidence: 99%

Mode of Potentiating Action of Cocaine in Morphine Analgesia

Shimada

Tsuda

Yanagita

1988

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

Abstract-The mechanism of antinociceptive interactions among morphine, cocaine and alcohol was studied in mice, guinea pigs and rabbits.In the tail-pressure test in mice, cocaine and alcohol alone showed almost no antinociceptive effects at doses up to 8 mg/kg, s.c., and 4 g/kg, i.g., respectively.Alcohol at 2 g/kg, i.g., also did not influence the effect of morphine, while cocaine at 4 mg/kg, s.c., significantly potentiated the antinociceptive effects of not only morphine but also pentazocine. In an analysis of serum and brain concentration levels of morphine in mice, when morphine and cocaine were simultaneously administered at 2 mg/kg, s.c., and 4 mg/kg, s.c., respectively, both serum and brain levels of morphine showed neither increase nor decrease in comparison with the levels in mice administered morphine alone.In myenteric plexus-longitudinal muscle preparations of isolated guinea pig ileum, 1 ,oM cocaine enhanced the agonistic effects of both pentazocine and ethylketocyclazocine.Furthermore, cocaine as well as ethylketocyclazocine showed naloxone-reversible agonistic effects in isolated rabbit vas deferens.These results indicate that cocaine may potentiate the antinociceptive effects of morphine and pentazocine by acting on the rc-opioid receptors as an agonist.

show abstract

mentioning

confidence: 99%

Mode of Potentiating Action of Cocaine in Morphine Analgesia

Shimada

Tsuda

Yanagita

1988

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

show abstract

“…As a parenteral analgesic it is 25-40 times more potent than morphine (Houde 1979). It was shown to relieve acute opioid withdrawal by Jasinski et al (1989).…”

Section: History and Formulationsmentioning

confidence: 99%

Buprenorphine prescription, misuse and service provision: a global perspective

Ho¹,

Chen²,

Broekman³

et al. 2009

Adv. psychiatr. treat

View full text Add to dashboard Cite

SummaryBuprenorphine, a partial μ-opioid agonist and κ-opioid antagonist, is recommended as safe and effective maintenance treatment for opioid dependence. It offers the possibility of management in primary care settings. However, its prescription has led to diversion for illicit recreational use and resulted in medical complications and, rarely, fatal overdose in combination with other sedatives. The outcome of buprenorphine maintenance programmes varies from country to country and it is determined by the local therapeutic traditions, regulatory restrictions and existing service provision for opioid misusers. This article addresses the pharmacology of buprenorphine, the benefits and drawbacks of its prescription, service provision for opioid misuse around the world, policy recommendations, and prescribing training requirements.

show abstract

“…63 The mixed agonist-antagonist subclass, particularly pentazocine, also have prominent psy chotomimetic effects.M65 Only pentazo cine has an oral formulation in this country, although the sublingual preparation of buprenorphine will probably become avail able in the near future.…”

Section: Switch Drugs If They Are Ineffectivementioning

confidence: 99%

Practical Aspects of Pain Control In the Patient with Cancer

Portenoy

1988

CA: A Cancer Journal for Clinicians

View full text Add to dashboard Cite

Analgesic effectiveness of the narcotic agonist‐antagonists.

Cited by 121 publications

References 42 publications

Mode of Potentiating Action of Cocaine in Morphine Analgesia

Mode of Potentiating Action of Cocaine in Morphine Analgesia

Buprenorphine prescription, misuse and service provision: a global perspective

Practical Aspects of Pain Control In the Patient with Cancer

Contact Info

Product

Resources

About