Analgesic Effect of Tramadol Is not Altered by Postoperative Systemic Inflammation after Major Abdominal Surgery

Nešković, Nenad; Marczi, Saška; Mandić, Dario; Mraović, Boris; Škiljić, Sonja; Kristek, Gordana; Vinković, Hrvoje; Kvolik, Slavica

doi:10.20471/acc.2021.60.02.13

Cited by 2 publications

(2 citation statements)

References 32 publications

(36 reference statements)

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“…Tramadol is a quasi-narcotic synthetic analgesic that acts primarily through low agonism of mu opioid receptors ([ 13 ]), and is used in the treatment of moderate to severe pain with consistent effectiveness ([ 14 ]). Tramadol prescription rose substantially in primary care and pain management settings, occasionally for prolonged durations and not in keeping with therapeutic guidance ([ 15 ]).…”

Section: Discussionmentioning

confidence: 99%

False Positive Tramadol Urine Testing in Patients Taking Fexofenadine: A Tale of Two Consecutive Cases

Yousuf

Alater

Alabdulla

et al. 2023

Case Reports in Psychiatry

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Urine drug screen immunoassays have been widely used as point-of-care testing for detection of various drug classes in substance use disorders. However, these immunoassays frequently result in false positive results. We report two patients that used 180 mg daily dose of fexofenadine hydrochloride for treatment of skin allergy and, falsely, tested positive for use of tramadol during urine drug screening. We recommend caution when interpreting positive tramadol urine screening among patients on fexofenadine treatment.

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Section: Discussionmentioning

confidence: 99%

False Positive Tramadol Urine Testing in Patients Taking Fexofenadine: A Tale of Two Consecutive Cases

Yousuf

Alater

Alabdulla

et al. 2023

Case Reports in Psychiatry

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“…The anti-inflammatory effect of the analgesic drugs used in this study might be the reason for a significant anaesthetic efficacy, as these drugs act by inhibiting the formation of AA, COX, and lipoxygenase pathways, and/or PGs and leukotrienes ( 34 ). While there is a strong division among researchers regarding whether Tramadol has anti-inflammatory potential or not ( 35 – 38 ), a study suggests that Tramadol helps to achieve effective analgesia irrespective of the presence of inflammation ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Preoperative Analgesics on the Efficacy of Inferior Alveolar Nerve Block with Patients Having Symptomatic Irreversible Pulpitis: A Double-Blinded, Randomized Controlled Trial

RIAZ

2023

Eur Endod J

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Objective The objective of this study was to evaluate the effectiveness of preoperative analgesics on inferior alveolar nerve blocks (IANB) during root canal treatment in patients with symptomatic irreversible pulpitis of the mandibular molars. Methods This study was a randomized, double-blinded, superiority trial with a parallel study design. A total of 120 subjects with symptomatic irreversible pulpitis were randomly assigned to one of four groups: group A (control, Vitamin E, Evion 400 mg), group B (Diclofenac sodium, Voltral SR100 100 mg), group C (Piroxicam, Feldene 20 mg), and group D (Tramadol, Tramal 50 mg). The patients recorded preoperative pain levels, and after administration of local anaesthesia intraoperative pain levels using the Heft-Parker visual analogue scale before and after the oral administration of the analgesics. Statistical analysis was performed using the Kruskal-Wallis test. Results All the analgesic groups showed a significant effect on the efficacy of the inferior alveolar nerve block in contrast to the control group (p<0.05). However, no significant difference was found between the drug groups on the effectiveness of the inferior alveolar nerve block (p>0.05). No side effects were reported in the present study. Conclusion Preoperative analgesics significantly increase the effectiveness of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis. Therefore, preoperative analgesics should be considered to increase the effectiveness of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis on the mandibular molars.

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Analgesic Effect of Tramadol Is not Altered by Postoperative Systemic Inflammation after Major Abdominal Surgery

Cited by 2 publications

References 32 publications

False Positive Tramadol Urine Testing in Patients Taking Fexofenadine: A Tale of Two Consecutive Cases

False Positive Tramadol Urine Testing in Patients Taking Fexofenadine: A Tale of Two Consecutive Cases

Comparison of Preoperative Analgesics on the Efficacy of Inferior Alveolar Nerve Block with Patients Having Symptomatic Irreversible Pulpitis: A Double-Blinded, Randomized Controlled Trial

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