Analgesic effect of prolactin: Possible mechanism of action

Ramaswamy, S.; Pillai, N. Padmanabha; Js, Bapna

doi:10.1016/0014-2999(83)90548-4

Cited by 33 publications

(14 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In one of these studies [37] evidence was presented, indicating that elevated circulating levels of PRL may be a causative factor in the reduction of stress responsiveness in the same way that hyperprolactinaemia is associated with analgesia [13,31]. We have now shown that hyperprolactinaemia, produced by administration of either dopamine antagonists or O-PRL, also reduces the OT response to stress.…”

Section: Discussionmentioning

confidence: 66%

Oxytocin Responses to Stress in Lactating and Hyperprolactinaemic Rats

Carter

Lightman²

1987

Neuroendocrinology

View full text Add to dashboard Cite

The plasma oxytocin (OT) response to acute stress was compared between virgin, lactating, and hyperprolactinaemic female rats. In virgin rats, brief immobilization was associated with a significant elevation of plasma OT to 24.7 ± 3.7 pmol/l compared with 7.7 ± 1.1 pmol/l in controls. In contrast, the stress response was absent in lactating (6 days post-partum) animals: control OT 9.4 ± 2.2, immobilized OT 9.0 ± 1.1 pmol/l. Hyperprolactinaemia produced by treatment with either dopamine antagonists (domperidone or haloperidol) or ovine prolactin was also associated with an impairment of the OT stress response in intact females, whereas domperidone treatment failed to modify the response in ovariectomized (OVX) rats. Following ovarian steroid replacement with oestradiol and progesterone, the inhibitory effect of domperidone was observed in OVX rats: control OT 11.1 ± 2.5, immobilized OT 16.0 ± 3.7 pmol/l. Treatment of OVX rats with oestradiol and progesterone, either separately or combined, did not modify the OT stress response. Plasma levels of vasopressin were not significantly modified in either control or immobilized rats of any experimental groups. The results indicate that hyperprolactinaemia may be a causative factor in the impairment of OT stress responses observed in lactating rats.

show abstract

Section: Discussionmentioning

confidence: 66%

Oxytocin Responses to Stress in Lactating and Hyperprolactinaemic Rats

Carter

Lightman²

1987

Neuroendocrinology

View full text Add to dashboard Cite

show abstract

“…Previous studies have documented such effects of centrally-administered PL in rats 40–41,46,49. However, in patients with PL-secreting pituitary adenomas, it has been shown patients with higher PL levels have worse headaches5 and a poorer overall quality of life 10.…”

Section: Discussionmentioning

confidence: 99%

Effects of Oxytocin and Prolactin on Stress-Induced Bladder Hypersensitivity in Female Rats

Black

Ness

Robbins

2009

The Journal of Pain

View full text Add to dashboard Cite

Anecdotal evidence suggests that chronic bladder pain improves while breastfeeding. The present study sought to identify potential mechanisms for such a phenomenon by investigating the effects of the lactogenic hormones prolactin (PL) and oxytocin (OXY) in a rat model of bladder nociception. Lactating rats were less sensitive to urinary bladder distension (UBD) than controls. In investigating potential antinociceptive and anxiolytic roles for these hormones, we found exposure to a footshock paradigm (STRESS groups) produced bladder hypersensitivity in saline-treated rats, manifested as significantly higher electromyographical (EMG) responses to UBD, compared to rats exposed to a non-footshock paradigm (SHAM groups). This hypersensitivity was attenuated by the intraperitoneal administration of OXY prior to footshock in the STRESS-OXY group. The administration of PL augmented EMG responses in the SHAM-PL group but had no effect on the responses of the STRESS-PL group. In the absence of behavioral pretreatment, OXY attenuated UBD-evoked responses while PL had no effect. Moreover, OXY-treated rats spent more time in the open arm of an elevated plus maze compared to saline-treated rats suggesting anxiolysis. These studies suggest the potential for systemic OXY, but not PL, as an analgesic and anxiolytic treatment for painful bladder disorders such as interstitial cystitis.

show abstract

“…1983). Prolactin, an endocrine peptide, produced an opioid mediated antinociceptive response (Ramaswamy et al 1983). A role for cholinergic and GABAergic systems in the action of prolactin has been noted (Ramaswamy et al 1986(Ramaswamy et al , 1989.…”

Section: Discussionmentioning

confidence: 99%

A Study on the Role of Cholinergic and Gamma Amino Butyric Acid Systems in the Anti‐nociceptive Effect of Gossypin

Viswanathan¹,

Thirugnanasambantham²,

Ramaswamy³

et al. 1993

Clin Exp Pharma Physio

View full text Add to dashboard Cite

1. The participation of cholinergic and gamma amino butyric acid (GABA) neurotransmitter systems in the anti-nociceptive effect of gossypin was investigated using pharmacological tools. 2. Physostigmine potentiated its anti-nociceptive response while atropine failed to modify it significantly. 3. THIP (4,5,6,7-tetra hydroisoxazolo (5,4-C) pyridin-3-ol) and gossypin treatment produced an additive response while bicuculline attenuated the anti-nociceptive response of gossypin. Similar observations were recorded for morphine. 4. It is suggested that cholinergic and GABAergic systems play a role in gossypin-induced anti-nociception.

show abstract

Analgesic effect of prolactin: Possible mechanism of action

Cited by 33 publications

References 10 publications

Oxytocin Responses to Stress in Lactating and Hyperprolactinaemic Rats

Oxytocin Responses to Stress in Lactating and Hyperprolactinaemic Rats

Effects of Oxytocin and Prolactin on Stress-Induced Bladder Hypersensitivity in Female Rats

A Study on the Role of Cholinergic and Gamma Amino Butyric Acid Systems in the Anti‐nociceptive Effect of Gossypin

Contact Info

Product

Resources

About