Analgesic effect of preoperative dezocine-based local anesthesia in patients undergoing inguinal hernia repair

Abstract

ObjectiveThis study was performed to investigate the analgesic effects of intramuscular injection of dezocine-based local anesthesia in patients undergoing inguinal hernia repair.MethodsA total of 120 patients underwent local herniorrhaphy from July 2015 to December 2016 and were randomly divided into 2 groups: the dezocine group, in which a preoperative intramuscular injection of dezocine was administered, and the control group, in which no dezocine injection was administered. The patients’ pain and comfort levels were evaluated at 30 minutes, 2 hours, 6 hours, 12 hours, and 24 hours postoperatively.ResultsThe visual analog scale scores at 30 minutes, 2 hours, 6 hours, 12 hours, and 24 hours were significantly lower in the dezocine than control group. In the Bruggemann comfort scale evaluation, patients who received dezocine injections showed significantly greater comfort than those in the control group at 30 minutes, 2 hours, 6 hours, 12 hours, and 24 hours. No adverse reactions occurred in the dezocine group.ConclusionsDezocine-based local anesthesia can attenuate postoperative pain and increase the comfort level during and after herniorrhaphy.

Dezocine as a potent analgesic: overview of its pharmacological characterization

“…Currently, dezocine is the mainstay opioids used in China for postoperative pain management. Intramuscular injection of dezocine produced effective analgesic effect and comfort in 60 patients undergoing inguinal hernia repair surgery for up to 24 h postoperatively [35]. In an open abdominal surgery, dezocine, 0.15 mg/kg intravenous given, offered significant antihyperalgesic and analgesic effect for up to 48 h postoperatively [36].…”

Effect of ketorolac tromethamine combined with dezocine prior administration on hemodynamics and postoperative analgesia in patients undergoing laparoscopic hernia repair

“…Therefore, in this study, preoperative intravenous administration of ketorolac tromethamine and dezocine was selected to reduce surgical stress and reduce the occurrence of hyperalgesia after remifentanil, improve the quality of patients’ recovery and reduce the occurrence of agitation and hemodynamic disorders during patients’ recovery, and the above observation indicators were selected. According to literature reports, [ 29 ] the prophylactic use of ketorolac tromethamine in laparoscopic inguinal hernia repair is safe and effective, and dezocine local anesthesia can relieve intraoperative and postoperative pain, improve postoperative comfort, [ 30 ] and relieve postoperative agitation in preschool children. [ 31 ] However, there have been no reports about the combined effect of ketorolac and dezocine on laparoscopic hernia repair.…”